PubMed

Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN.

Mahimainathan L, Das F, Venkatesan B, Choudhury GG.

Diabetes. 2006 Jul;55(7):2115-25.PMID: 16804083 [PubMed - indexed for MEDLINE]Related articlesFree article

Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy.

Nagai K, Matsubara T, Mima A, Sumi E, Kanamori H, Iehara N, Fukatsu A, Yanagita M, Nakano T, Ishimoto Y, Kita T, Doi T, Arai H.

Kidney Int. 2005 Aug;68(2):552-61.PMID: 16014032 [PubMed - indexed for MEDLINE]Related articles

Role of growth arrest-specific gene 6 in diabetic nephropathy.

Arai H, Nagai K, Doi T.

Vitam Horm. 2008;78:375-92. Review.PMID: 18374201 [PubMed - indexed for MEDLINE]Related articles

Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney.

Lee EA, Seo JY, Jiang Z, Yu MR, Kwon MK, Ha H, Lee HB.

Kidney Int. 2005 May;67(5):1762-71.PMID: 15840023 [PubMed - indexed for MEDLINE]Related articles

High glucose induces type 1 hexokinase gene expression in isolated glomeruli of diabetic rats and in mesangial cells.

Henningsen C, Zahner G, Thaiss F.

Nephron Physiol. 2003;93(3):p67-75.PMID: 12660493 [PubMed - indexed for MEDLINE]Related articles

Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice.

Sharma K, Jin Y, Guo J, Ziyadeh FN.

Diabetes. 1996 Apr;45(4):522-30.PMID: 8603776 [PubMed - indexed for MEDLINE]Related articles

Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells.

Wu D, Peng F, Zhang B, Ingram AJ, Gao B, Krepinsky JC.

Diabetologia. 2007 Sep;50(9):2008-18. Epub 2007 Jul 11.PMID: 17622510 [PubMed - indexed for MEDLINE]Related articles

The effects of high glucose concentration on angiotensin II- or transforming growth factor-beta-induced DNA synthesis, hypertrophy and collagen synthesis in cultured rat mesangial cells.

Choi KH, Kang SW, Lee HY, Han DS.

Yonsei Med J. 1996 Oct;37(5):302-11.PMID: 8997162 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of transforming growth factor-beta 1 during diabetic renal hypertrophy.

Shankland SJ, Scholey JW, Ly H, Thai K.

Kidney Int. 1994 Aug;46(2):430-42.PMID: 7967355 [PubMed - indexed for MEDLINE]Related articles

Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator.

Sharma K, Ziyadeh FN.

Diabetes. 1995 Oct;44(10):1139-46. Review.PMID: 7556948 [PubMed - indexed for MEDLINE]Related articles

The lack of cyclin kinase inhibitor p27(Kip1) ameliorates progression of diabetic nephropathy.

Awazu M, Omori S, Ishikura K, Hida M, Fujita H.

J Am Soc Nephrol. 2003 Mar;14(3):699-708.PMID: 12595506 [PubMed - indexed for MEDLINE]Related articlesFree article

Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells.

Lin CL, Wang JY, Huang YT, Kuo YH, Surendran K, Wang FS.

J Am Soc Nephrol. 2006 Oct;17(10):2812-20. Epub 2006 Aug 30.PMID: 16943306 [PubMed - indexed for MEDLINE]Related articlesFree article

Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner.

Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, Zou MH.

Circulation. 2007 Oct 2;116(14):1585-95. Epub 2007 Sep 17.PMID: 17875968 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressions of chronic glomerular injuries and TGF-beta 1 production by HGF in attenuation of murine diabetic nephropathy.

Mizuno S, Nakamura T.

Am J Physiol Renal Physiol. 2004 Jan;286(1):F134-43. Epub 2003 Sep 30.PMID: 14519594 [PubMed - indexed for MEDLINE]Related articlesFree article

Delayed treatment with lithospermate B attenuates experimental diabetic renal injury.

Lee GT, Ha H, Jung M, Li H, Hong SW, Cha BS, Lee HC, Cho YD.

J Am Soc Nephrol. 2003 Mar;14(3):709-20.PMID: 12595507 [PubMed - indexed for MEDLINE]Related articlesFree article

RAGE- and TGF-beta receptor-mediated signals converge on STAT5 and p21waf to control cell-cycle progression of mesangial cells: a possible role in the development and progression of diabetic nephropathy.

Brizzi MF, Dentelli P, Rosso A, Calvi C, Gambino R, Cassader M, Salvidio G, Deferrari G, Camussi G, Pegoraro L, Pagano G, Cavallo-Perin P.

FASEB J. 2004 Aug;18(11):1249-51. Epub 2004 Jun 4.PMID: 15180953 [PubMed - indexed for MEDLINE]Related articlesFree article

p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency.

Wolf G, Schanze A, Stahl RA, Shankland SJ, Amann K.

Kidney Int. 2005 Oct;68(4):1583-9.PMID: 16164635 [PubMed - indexed for MEDLINE]Related articles

TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN.

Kato M, Putta S, Wang M, Yuan H, Lanting L, Nair I, Gunn A, Nakagawa Y, Shimano H, Todorov I, Rossi JJ, Natarajan R.

Nat Cell Biol. 2009 Jul;11(7):881-9. Epub 2009 Jun 21.PMID: 19543271 [PubMed - indexed for MEDLINE]Related articles

Downregulation of catalase by reactive oxygen species via PI 3 kinase/Akt signaling in mesangial cells.

Venkatesan B, Mahimainathan L, Das F, Ghosh-Choudhury N, Ghosh Choudhury G.

J Cell Physiol. 2007 May;211(2):457-67.PMID: 17186497 [PubMed - indexed for MEDLINE]Related articles

Stimulation of TGF-beta type II receptor by high glucose in mouse mesangial cells and in diabetic kidney.

Isono M, Mogyorósi A, Han DC, Hoffman BB, Ziyadeh FN.

Am J Physiol Renal Physiol. 2000 May;278(5):F830-8.PMID: 10807596 [PubMed - indexed for MEDLINE]Related articlesFree article