PubMed

Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c.

Biddinger SB, Miyazaki M, Boucher J, Ntambi JM, Kahn CR.

Diabetes. 2006 Jul;55(7):2032-41.PMID: 16804073 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice.

Flowers JB, Rabaglia ME, Schueler KL, Flowers MT, Lan H, Keller MP, Ntambi JM, Attie AD.

Diabetes. 2007 May;56(5):1228-39. Epub 2007 Mar 16.PMID: 17369521 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome.

Biddinger SB, Almind K, Miyazaki M, Kokkotou E, Ntambi JM, Kahn CR.

Diabetes. 2005 May;54(5):1314-23.PMID: 15855315 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms.

Miyazaki M, Dobrzyn A, Man WC, Chu K, Sampath H, Kim HJ, Ntambi JM.

J Biol Chem. 2004 Jun 11;279(24):25164-71. Epub 2004 Apr 5.PMID: 15066988 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice.

Miyazaki M, Sampath H, Liu X, Flowers MT, Chu K, Dobrzyn A, Ntambi JM.

Biochem Biophys Res Commun. 2009 Mar 20;380(4):818-22. Epub 2009 Feb 5.PMID: 19338759 [PubMed - indexed for MEDLINE]Related articles

Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors.

Miyazaki M, Jacobson MJ, Man WC, Cohen P, Asilmaz E, Friedman JM, Ntambi JM.

J Biol Chem. 2003 Sep 5;278(36):33904-11. Epub 2003 Jun 18.PMID: 12815040 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism.

Kim HJ, Miyazaki M, Ntambi JM.

J Lipid Res. 2002 Oct;43(10):1750-7.PMID: 12364560 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation.

Chu K, Miyazaki M, Man WC, Ntambi JM.

Mol Cell Biol. 2006 Sep;26(18):6786-98.PMID: 16943421 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-coenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferator-activated receptor-alpha: independent and interactive roles in the regulation of lipid metabolism.

Sampath H, Ntambi JM.

Curr Opin Clin Nutr Metab Care. 2006 Mar;9(2):84-8. Review.PMID: 16477170 [PubMed - indexed for MEDLINE]Related articles

Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle.

Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM.

Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E599-607. Epub 2004 Nov 23.PMID: 15562249 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat.

Sampath H, Miyazaki M, Dobrzyn A, Ntambi JM.

J Biol Chem. 2007 Jan 26;282(4):2483-93. Epub 2006 Nov 23.PMID: 17127673 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-CoA desaturase--a new player in skeletal muscle metabolism regulation.

Dobrzyń A, Dobrzyń P.

J Physiol Pharmacol. 2006 Nov;57 Suppl 10:31-42. Review.PMID: 17242489 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-CoA desaturase as a new drug target for obesity treatment.

Dobrzyn A, Ntambi JM.

Obes Rev. 2005 May;6(2):169-74. Review.PMID: 15836467 [PubMed - indexed for MEDLINE]Related articles

Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart.

Dobrzyn P, Sampath H, Dobrzyn A, Miyazaki M, Ntambi JM.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E357-64. Epub 2007 Nov 27.PMID: 18042664 [PubMed - indexed for MEDLINE]Related articlesFree article

Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype.

Segal-Lieberman G, Bradley RL, Kokkotou E, Carlson M, Trombly DJ, Wang X, Bates S, Myers MG Jr, Flier JS, Maratos-Flier E.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10085-90. Epub 2003 Aug 1.PMID: 12897241 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.

Sekiya M, Yahagi N, Matsuzaka T, Najima Y, Nakakuki M, Nagai R, Ishibashi S, Osuga J, Yamada N, Shimano H.

Hepatology. 2003 Dec;38(6):1529-39.PMID: 14647064 [PubMed - indexed for MEDLINE]Related articles

Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice.

Matsusue K, Gavrilova O, Lambert G, Brewer HB Jr, Ward JM, Inoue Y, LeRoith D, Gonzalez FJ.

Mol Endocrinol. 2004 Nov;18(11):2751-64. Epub 2004 Aug 19.PMID: 15319454 [PubMed - indexed for MEDLINE]Related articlesFree article

Melanin-concentrating hormone receptor 1 deficiency increases insulin sensitivity in obese leptin-deficient mice without affecting body weight.

Bjursell M, Gerdin AK, Ploj K, Svensson D, Svensson L, Oscarsson J, Snaith M, Törnell J, Bohlooly-Y M.

Diabetes. 2006 Mar;55(3):725-33.PMID: 16505236 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-CoA desaturase-1 and the metabolic syndrome.

Cohen P, Ntambi JM, Friedman JM.

Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):271-80. Review.PMID: 14683458 [PubMed - indexed for MEDLINE]Related articles

Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.

Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, Sharma R, Hudgins LC, Ntambi JM, Friedman JM.

Science. 2002 Jul 12;297(5579):240-3.PMID: 12114623 [PubMed - indexed for MEDLINE]Related articlesFree article