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    Results: 1 to 20 of 483

    1.

    Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage.

    Ho EC, Lam KS, Chen YS, Yip JC, Arvindakshan M, Yamagishi S, Yagihashi S, Oates PJ, Ellery CA, Chung SS, Chung SK.

    Diabetes. 2006 Jul;55(7):1946-53.PMID: 16804062 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications.

    Obrosova IG, Pacher P, Szabó C, Zsengeller Z, Hirooka H, Stevens MJ, Yorek MA.

    Diabetes. 2005 Jan;54(1):234-42.PMID: 15616034 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    The role of cyclic adenosine 3',5'-monophosphate and polyol metabolism in diabetic neuropathy.

    Shindo H, Tawata M, Aida K, Onaya T.

    J Clin Endocrinol Metab. 1992 Feb;74(2):393-8.PMID: 1370506 [PubMed - indexed for MEDLINE]Related articles

    4.

    Effects of sorbitol dehydrogenase deficiency on nerve conduction in experimental diabetic mice.

    Ng TF, Lee FK, Song ZT, Calcutt NA, Lee AY, Chung SS, Chung SK.

    Diabetes. 1998 Jun;47(6):961-6. Erratum in: Diabetes 1998 Aug;47(8):1374. Ng, DT [corrected to Ng, TF]; Lee, LW [corrected to Lee, AY]. PMID: 9604875 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats.

    Kato N, Mizuno K, Makino M, Suzuki T, Yagihashi S.

    Diabetes Res Clin Pract. 2000 Oct;50(2):77-85.PMID: 10960717 [PubMed - indexed for MEDLINE]Related articles

    6.

    Neuropathy in diabetic mice overexpressing human aldose reductase and effects of aldose reductase inhibitor.

    Yagihashi S, Yamagishi SI, Wada Ri R, Baba M, Hohman TC, Yabe-Nishimura C, Kokai Y.

    Brain. 2001 Dec;124(Pt 12):2448-58.PMID: 11701599 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Transgenic mice overexpressing aldose reductase in Schwann cells show more severe nerve conduction velocity deficit and oxidative stress under hyperglycemic stress.

    Song Z, Fu DT, Chan YS, Leung S, Chung SS, Chung SK.

    Mol Cell Neurosci. 2003 Aug;23(4):638-47.PMID: 12932443 [PubMed - indexed for MEDLINE]Related articles

    8.

    Phosphorylation of c-Jun N-terminal kinase (JNK) in sensory neurones of diabetic rats, with possible effects on nerve conduction and neuropathic pain: prevention with an aldose reductase inhibitor.

    Middlemas AB, Agthong S, Tomlinson DR.

    Diabetologia. 2006 Mar;49(3):580-7. Epub 2006 Feb 3.PMID: 16456679 [PubMed - indexed for MEDLINE]Related articles

    9.

    Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats.

    Cameron NE, Cotter MA, Basso M, Hohman TC.

    Diabetologia. 1997 Mar;40(3):271-81.PMID: 9084964 [PubMed - indexed for MEDLINE]Related articles

    10.

    Effect of a potent new aldose reductase inhibitor, (5-(3-thienyltetrazol-1-yl)acetic acid (TAT), on diabetic neuropathy in rats.

    Hotta N, Kakuta H, Fukasawa H, Koh N, Sakakibara F, Nakamura J, Hamada Y, Wakao T, Hara T, Mori K, et al.

    Diabetes Res Clin Pract. 1995 Feb;27(2):107-17.PMID: 7607048 [PubMed - indexed for MEDLINE]Related articles

    11.

    Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition.

    Gillon KR, Hawthorne JN, Tomlinson DR.

    Diabetologia. 1983 Oct;25(4):365-71.PMID: 6416913 [PubMed - indexed for MEDLINE]Related articles

    12.

    Continuous inhibition of excessive polyol pathway flux in peripheral nerves by aldose reductase inhibitor fidarestat leads to improvement of diabetic neuropathy.

    Mizuno K, Kato N, Makino M, Suzuki T, Shindo M.

    J Diabetes Complications. 1999 May-Jun;13(3):141-50.PMID: 10509874 [PubMed - indexed for MEDLINE]Related articles

    13.

    Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.

    Obrosova IG, Minchenko AG, Vasupuram R, White L, Abatan OI, Kumagai AK, Frank RN, Stevens MJ.

    Diabetes. 2003 Mar;52(3):864-71.PMID: 12606532 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux.

    Matsumoto T, Ono Y, Kurono M, Kuromiya A, Nakamura K, Bril V.

    J Pharmacol Sci. 2009 Feb;109(2):203-10. Epub 2009 Feb 10.PMID: 19212096 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase.

    Price SA, Agthong S, Middlemas AB, Tomlinson DR.

    Diabetes. 2004 Jul;53(7):1851-6.PMID: 15220210 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Slowing of motor nerve conduction velocity in streptozotocin-induced diabetic rats is preceded by impaired vasodilation in arterioles that overlie the sciatic nerve.

    Coppey LJ, Davidson EP, Dunlap JA, Lund DD, Yorek MA.

    Int J Exp Diabetes Res. 2000;1(2):131-43.PMID: 11469397 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Preventive effect of long-term aldose reductase inhibition (ponalrestat) on nerve conduction and sural nerve structure in the spontaneously diabetic Bio-Breeding rat.

    Sima AA, Prashar A, Zhang WX, Chakrabarti S, Greene DA.

    J Clin Invest. 1990 May;85(5):1410-20.PMID: 2110189 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Effect of the aldose reductase inhibitor fidarestat on experimental diabetic neuropathy in the rat.

    Kuzumoto Y, Kusunoki S, Kato N, Kihara M, Low PA.

    Diabetologia. 2006 Dec;49(12):3085-93. Epub 2006 Oct 25.PMID: 17063327 [PubMed - indexed for MEDLINE]Related articles

    19.

    Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat.

    Stevens MJ, Lattimer SA, Kamijo M, Van Huysen C, Sima AA, Greene DA.

    Diabetologia. 1993 Jul;36(7):608-14.PMID: 8359577 [PubMed - indexed for MEDLINE]Related articles

    20.

    Effect of the aldose reductase inhibitor tolrestat on nerve conduction velocity, Na/K ATPase activity, and polyols in red blood cells, sciatic nerve, kidney cortex, and kidney medulla of diabetic rats.

    Raccah D, Coste T, Cameron NE, Dufayet D, Vague P, Hohman TC.

    J Diabetes Complications. 1998 May-Jun;12(3):154-62.PMID: 9618071 [PubMed - indexed for MEDLINE]Related articles

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