PubMed

Spontaneous recovery from hyperglycemia by regeneration of pancreatic beta-cells in Kir6.2G132S transgenic mice.

Oyama K, Minami K, Ishizaki K, Fuse M, Miki T, Seino S.

Diabetes. 2006 Jul;55(7):1930-8.PMID: 16804060 [PubMed - indexed for MEDLINE]Related articlesFree article

Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice.

Seino S, Iwanaga T, Nagashima K, Miki T.

Diabetes. 2000 Mar;49(3):311-8. Review.PMID: 10868950 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel.

Miki T, Tashiro F, Iwanaga T, Nagashima K, Yoshitomi H, Aihara H, Nitta Y, Gonoi T, Inagaki N, Miyazaki J, Seino S.

Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11969-73.PMID: 9342346 [PubMed - indexed for MEDLINE]Related articlesFree article

Roles of ATP-sensitive K+ channels in cell survival and differentiation in the endocrine pancreas.

Miki T, Iwanaga T, Nagashima K, Ihara Y, Seino S.

Diabetes. 2001 Feb;50 Suppl 1:S48-51.PMID: 11272201 [PubMed - indexed for MEDLINE]Related articles

KATP channel-deficient pancreatic beta-cells are streptozotocin resistant because of lower GLUT2 activity.

Xu J, Zhang L, Chou A, Allaby T, Bélanger G, Radziuk J, Jasmin BJ, Miki T, Seino S, Renaud JM.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E326-35. Epub 2007 Nov 27.PMID: 18042662 [PubMed - indexed for MEDLINE]Related articlesFree article

K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes.

Kanezaki Y, Obata T, Matsushima R, Minami A, Yuasa T, Kishi K, Bando Y, Uehara H, Izumi K, Mitani T, Matsumoto M, Takeshita Y, Nakaya Y, Matsumoto T, Ebina Y.

Endocr J. 2004 Apr;51(2):133-44.PMID: 15118262 [PubMed - indexed for MEDLINE]Related articlesFree article

Gastric inhibitory polypeptide is the major insulinotropic factor in K(ATP) null mice.

Tsukiyama K, Yamada Y, Miyawaki K, Hamasaki A, Nagashima K, Hosokawa M, Fujimoto S, Takahashi A, Toyoda K, Toyokuni S, Oiso Y, Seino Y.

Eur J Endocrinol. 2004 Sep;151(3):407-12.PMID: 15362972 [PubMed - indexed for MEDLINE]Related articlesFree article

Localization of the ATP-sensitive K+ channel subunit Kir6.2 in mouse pancreas.

Suzuki M, Fujikura K, Inagaki N, Seino S, Takata K.

Diabetes. 1997 Sep;46(9):1440-4.PMID: 9287044 [PubMed - indexed for MEDLINE]Related articles

Morphological changes in pancreatic islets of KATP channel-deficient mice: the involvement of KATP channels in the survival of insulin cells and the maintenance of islet architecture.

Winarto A, Miki T, Seino S, Iwanaga T.

Arch Histol Cytol. 2001 Feb;64(1):59-67.PMID: 11310506 [PubMed - indexed for MEDLINE]Related articlesFree article

Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.

Nielsen LB, Ploug KB, Swift P, Ørskov C, Jansen-Olesen I, Chiarelli F, Holst JJ, Hougaard P, Pörksen S, Holl R, de Beaufort C, Gammeltoft S, Rorsman P, Mortensen HB, Hansen L; Hvidøre Study Group.

Eur J Endocrinol. 2007 Jun;156(6):663-71.PMID: 17535866 [PubMed - indexed for MEDLINE]Related articlesFree article

Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells develop diabetes.

Davani B, Portwood N, Bryzgalova G, Reimer MK, Heiden T, Ostenson CG, Okret S, Ahren B, Efendic S, Khan A.

Diabetes. 2004 Feb;53 Suppl 1:S51-9.PMID: 14749266 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinism in mice with heterozygous loss of K(ATP) channels.

Remedi MS, Rocheleau JV, Tong A, Patton BL, McDaniel ML, Piston DW, Koster JC, Nichols CG.

Diabetologia. 2006 Oct;49(10):2368-78. Epub 2006 Aug 19.PMID: 16924481 [PubMed - indexed for MEDLINE]Related articles

Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion.

De León DD, Li C, Delson MI, Matschinsky FM, Stanley CA, Stoffers DA.

J Biol Chem. 2008 Sep 19;283(38):25786-93. Epub 2008 Jul 17.PMID: 18635551 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels.

Remedi MS, Koster JC, Markova K, Seino S, Miki T, Patton BL, McDaniel ML, Nichols CG.

Diabetes. 2004 Dec;53(12):3159-67.PMID: 15561946 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet cell proliferation and apoptosis in insulin-like growth factor binding protein-1 in transgenic mice.

Dheen ST, Rajkumar K, Murphy LJ.

J Endocrinol. 1997 Dec;155(3):551-8.PMID: 9488000 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of ATP-insensitive KATP channels in pancreatic beta-cells underlies a spectrum of diabetic phenotypes.

Koster JC, Remedi MS, Masia R, Patton B, Tong A, Nichols CG.

Diabetes. 2006 Nov;55(11):2957-64.PMID: 17065331 [PubMed - indexed for MEDLINE]Related articlesFree article

Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release.

Misaki N, Mao X, Lin YF, Suga S, Li GH, Liu Q, Chang Y, Wang H, Wakui M, Wu J.

J Pharmacol Exp Ther. 2007 Aug;322(2):871-8. Epub 2007 May 23.PMID: 17522344 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased and persistent circulating insulin-like growth factor II in neonatal transgenic mice suppresses developmental apoptosis in the pancreatic islets.

Hill DJ, Strutt B, Arany E, Zaina S, Coukell S, Graham CF.

Endocrinology. 2000 Mar;141(3):1151-7.PMID: 10698192 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes and hypoglycaemia in young children and mutations in the Kir6.2 subunit of the potassium channel: therapeutic consequences.

Flechtner I, de Lonlay P, Polak M.

Diabetes Metab. 2006 Dec;32(6):569-80. Review.PMID: 17296510 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes.

Koster JC, Marshall BA, Ensor N, Corbett JA, Nichols CG.

Cell. 2000 Mar 17;100(6):645-54.PMID: 10761930 [PubMed - indexed for MEDLINE]Related articles