PubMed

RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis.

Watts KL, Cottrell E, Hoban PR, Spiteri MA.

Respir Res. 2006 Jun 15;7:88.PMID: 16776827 [PubMed - indexed for MEDLINE]Related articlesFree article

Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts.

Watts KL, Sampson EM, Schultz GS, Spiteri MA.

Am J Respir Cell Mol Biol. 2005 Apr;32(4):290-300. Epub 2005 Jan 27.PMID: 15677772 [PubMed - indexed for MEDLINE]Related articlesFree article

Connective tissue growth factor expression and induction by transforming growth factor-beta is abrogated by simvastatin via a Rho signaling mechanism.

Watts KL, Spiteri MA.

Am J Physiol Lung Cell Mol Physiol. 2004 Dec;287(6):L1323-32. Epub 2004 Aug 6.PMID: 15298857 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression.

Black SA Jr, Trackman PC.

J Biol Chem. 2008 Apr 18;283(16):10835-47. Epub 2008 Feb 20.PMID: 18287089 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells.

Itoh Y, Kimoto K, Imaizumi M, Nakatsuka K.

Exp Eye Res. 2007 Mar;84(3):464-72. Epub 2007 Jan 10.PMID: 17217948 [PubMed - indexed for MEDLINE]Related articles

Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27.

Weber JD, Hu W, Jefcoat SC Jr, Raben DM, Baldassare JJ.

J Biol Chem. 1997 Dec 26;272(52):32966-71.PMID: 9407076 [PubMed - indexed for MEDLINE]Related articlesFree article

TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2).

Strutz F, Zeisberg M, Renziehausen A, Raschke B, Becker V, van Kooten C, Müller G.

Kidney Int. 2001 Feb;59(2):579-92.PMID: 11168939 [PubMed - indexed for MEDLINE]Related articlesFree article

Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins).

Eberlein M, Heusinger-Ribeiro J, Goppelt-Struebe M.

Br J Pharmacol. 2001 Aug;133(7):1172-80.PMID: 11487529 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP.

Heusinger-Ribeiro J, Eberlein M, Wahab NA, Goppelt-Struebe M.

J Am Soc Nephrol. 2001 Sep;12(9):1853-61.PMID: 11518778 [PubMed - indexed for MEDLINE]Related articlesFree article

Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-beta1-induced release of extracellular fibroblast growth factor-2 and phosphorylation of p38 MAPK and JNK.

Khalil N, Xu YD, O'Connor R, Duronio V.

J Biol Chem. 2005 Dec 30;280(52):43000-9. Epub 2005 Oct 24.PMID: 16246848 [PubMed - indexed for MEDLINE]Related articlesFree article

RhoA and Rho-kinase dependent and independent signals mediate TGF-beta-induced pulmonary endothelial cytoskeletal reorganization and permeability.

Clements RT, Minnear FL, Singer HA, Keller RS, Vincent PA.

Am J Physiol Lung Cell Mol Physiol. 2005 Feb;288(2):L294-306. Epub 2004 Oct 8.PMID: 15475381 [PubMed - indexed for MEDLINE]Related articlesFree article

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.

Park HJ, Kong D, Iruela-Arispe L, Begley U, Tang D, Galper JB.

Circ Res. 2002 Jul 26;91(2):143-50.PMID: 12142347 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of cyclin E overexpression on lovastatin-induced G1 arrest and RhoA inactivation in NIH3T3 cells.

Ghosh PM, Moyer ML, Mott GE, Kreisberg JI.

J Cell Biochem. 1999 Sep 15;74(4):532-43.PMID: 10440923 [PubMed - indexed for MEDLINE]Related articles

Angiotensin-TGF-beta 1 crosstalk in human idiopathic pulmonary fibrosis: autocrine mechanisms in myofibroblasts and macrophages.

Uhal BD, Kim JK, Li X, Molina-Molina M.

Curr Pharm Des. 2007;13(12):1247-56. Review.PMID: 17504233 [PubMed - indexed for MEDLINE]Related articles

Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling.

Kunzmann S, Schmidt-Weber C, Zingg JM, Azzi A, Kramer BW, Blaser K, Akdis CA, Speer CP.

J Allergy Clin Immunol. 2007 Jun;119(6):1398-407. Epub 2007 Apr 6.PMID: 17412405 [PubMed - indexed for MEDLINE]Related articles

Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF.

Pan LH, Yamauchi K, Uzuki M, Nakanishi T, Takigawa M, Inoue H, Sawai T.

Eur Respir J. 2001 Jun;17(6):1220-7.PMID: 11491168 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue inhibitor of metalloproteinase-3 is up-regulated by transforming growth factor-beta1 in vitro and expressed in fibroblastic foci in vivo in idiopathic pulmonary fibrosis.

García-Alvarez J, Ramirez R, Checa M, Nuttall RK, Sampieri CL, Edwards DR, Selman M, Pardo A.

Exp Lung Res. 2006 May;32(5):201-14.PMID: 16908447 [PubMed - indexed for MEDLINE]Related articles

Lipoxin A4 inhibits proliferation of human lung fibroblasts induced by connective tissue growth factor.

Wu SH, Wu XH, Lu C, Dong L, Chen ZQ.

Am J Respir Cell Mol Biol. 2006 Jan;34(1):65-72. Epub 2005 Sep 1.PMID: 16141446 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress.

Cicha I, Goppelt-Struebe M, Muehlich S, Yilmaz A, Raaz D, Daniel WG, Garlichs CD.

Atherosclerosis. 2008 Jan;196(1):136-45. Epub 2007 Apr 23.PMID: 17452038 [PubMed - indexed for MEDLINE]Related articles

Hammerhead ribozyme targeting connective tissue growth factor mRNA blocks transforming growth factor-beta mediated cell proliferation.

Blalock TD, Yuan R, Lewin AS, Schultz GS.

Exp Eye Res. 2004 Jun;78(6):1127-36.PMID: 15109919 [PubMed - indexed for MEDLINE]Related articles