PubMed

The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.

Desai M, Zeggini E, Horton VA, Owen KR, Hattersley AT, Levy JC, Hitman GA, Walker M, Holman RR, McCarthy MI, Clark A.

Diabetes. 2006 Jun;55(6):1890-4.PMID: 16731859 [PubMed - indexed for MEDLINE]Related articlesFree article

Variable number of tandem repeats of the insulin gene determines susceptibility to latent autoimmune diabetes in adults.

Cerrone GE, Caputo M, Lopez AP, González C, Massa C, Cédola N, Targovnik HM, Frechtel GD.

Mol Diagn. 2004;8(1):43-9.PMID: 15230641 [PubMed - indexed for MEDLINE]Related articles

HLA DRB1, DQB1 and insulin promoter VNTR polymorphisms: interactions and the association with adult-onset diabetes mellitus in Czech patients.

Cejkova P, Novota P, Cerna M, Kolostova K, Novakova D, Kucera P, Novak J, Andel M, Weber P, Zdarsky E.

Int J Immunogenet. 2008 Apr;35(2):133-40. Epub 2008 Feb 11.PMID: 18279373 [PubMed - indexed for MEDLINE]Related articles

Insulin gene VNTR, CTLA-4 +49A/G and HLA-DQB1 alleles distinguish latent autoimmune diabetes in adults from type 1 diabetes and from type 2 diabetes group.

Haller K, Kisand K, Pisarev H, Salur L, Laisk T, Nemvalts V, Uibo R.

Tissue Antigens. 2007 Feb;69(2):121-7.PMID: 17257313 [PubMed - indexed for MEDLINE]Related articles

CTLA4 gene polymorphism contributes to the mode of onset of diabetes with antiglutamic acid decarboxylase antibody in Japanese patients: genetic analysis of diabetic patients with antiglutamic acid decarboxylase antibody.

Abe T, Yamaguchi Y, Takino H, Fujita N, Yamauchi-Degawa M, Ozaki M, Yamakawa K, Sera Y, Sakamaki H, Uotani S, Kawasaki E, Awata T, Yamasaki H, Eguchi K.

Diabet Med. 2001 Sep;18(9):726-31.PMID: 11606170 [PubMed - indexed for MEDLINE]Related articles

Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes.

Awata T, Kawasaki E, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Iizuka H, Kurihara S, Osaki M, Uga M, Kawabata Y, Tanaka S, Kanazawa Y, Katayama S.

J Clin Endocrinol Metab. 2007 May;92(5):1791-5. Epub 2007 Mar 6.PMID: 17341563 [PubMed - indexed for MEDLINE]Related articlesFree article

An association analysis of the HLA gene region in latent autoimmune diabetes in adults.

Desai M, Zeggini E, Horton VA, Owen KR, Hattersley AT, Levy JC, Walker M, Gillespie KM, Bingley PJ, Hitman GA, Holman RR, McCarthy MI, Clark A.

Diabetologia. 2007 Jan;50(1):68-73. Epub 2006 Dec 2.PMID: 17143607 [PubMed - indexed for MEDLINE]Related articles

Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.

Vafiadis P, Ounissi-Benkalha H, Palumbo M, Grabs R, Rousseau M, Goodyer CG, Polychronakos C.

J Clin Endocrinol Metab. 2001 Aug;86(8):3705-10.PMID: 11502799 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.

Cervin C, Lyssenko V, Bakhtadze E, Lindholm E, Nilsson P, Tuomi T, Cilio CM, Groop L.

Diabetes. 2008 May;57(5):1433-7. Epub 2008 Feb 29.PMID: 18310307 [PubMed - indexed for MEDLINE]Related articlesFree article

Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release.

Hansen SK, Gjesing AP, Rasmussen SK, Glümer C, Urhammer SA, Andersen G, Rose CS, Drivsholm T, Torekov SK, Jensen DP, Ekstrøm CT, Borch-Johnsen K, Jørgensen T, McCarthy MI, Hansen T, Pedersen O.

Diabetologia. 2004 Jun;47(6):1079-87. Epub 2004 May 29.PMID: 15170498 [PubMed - indexed for MEDLINE]Related articles

Lack of support for a role of the insulin gene variable number of tandem repeats minisatellite (INS-VNTR) locus in fetal growth or type 2 diabetes-related intermediate traits in United Kingdom populations.

Mitchell SM, Hattersley AT, Knight B, Turner T, Metcalf BS, Voss LD, Davies D, McCarthy A, Wilkin TJ, Smith GD, Ben-Shlomo Y, Frayling TM.

J Clin Endocrinol Metab. 2004 Jan;89(1):310-7.PMID: 14715866 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.

Huxtable SJ, Saker PJ, Haddad L, Walker M, Frayling TM, Levy JC, Hitman GA, O'Rahilly S, Hattersley AT, McCarthy MI.

Diabetes. 2000 Jan;49(1):126-30.PMID: 10615960 [PubMed - indexed for MEDLINE]Related articlesFree article

IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.

Bennett ST, Wilson AJ, Cucca F, Nerup J, Pociot F, McKinney PA, Barnett AH, Bain SC, Todd JA.

J Autoimmun. 1996 Jun;9(3):415-21.PMID: 8816980 [PubMed - indexed for MEDLINE]Related articles

Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes.

Stead JD, Buard J, Todd JA, Jeffreys AJ.

Hum Mol Genet. 2000 Dec 12;9(20):2929-35.PMID: 11115836 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA in Czech adult patients with autoimmune diabetes mellitus: comparison with Czech children with type 1 diabetes and patients with type 2 diabetes.

Cerna M, Novota P, Kolostova K, Cejkova P, Zdarsky E, Novakova D, Kucera P, Novak J, Andel M.

Eur J Immunogenet. 2003 Dec;30(6):401-7.PMID: 14675393 [PubMed - indexed for MEDLINE]Related articles

Insulin gene 5' flanking polymorphism. Length of class 1 alleles in number of repeat units.

McGinnis RE, Spielman RS.

Diabetes. 1995 Nov;44(11):1296-302.PMID: 7589827 [PubMed - indexed for MEDLINE]Related articles

Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene.

Doria A, Lee J, Warram JH, Krolewski AS.

Diabetologia. 1996 May;39(5):594-9.PMID: 8739920 [PubMed - indexed for MEDLINE]Related articles

[HLA DQB1 genotyping in latent autoimmune diabetes of adults (LADA)]

Caputo M, Cerrone GE, Lopez AP, Gonzalez C, Mazza C, Cedola N, Puchulu FM, Targovnik HM, Frechtel GD.

Medicina (B Aires). 2005;65(3):235-40. Spanish. PMID: 16042135 [PubMed - indexed for MEDLINE]Related articles

Similar genetic features and different islet cell autoantibody pattern of latent autoimmune diabetes in adults (LADA) compared with adult-onset type 1 diabetes with rapid progression.

Hosszúfalusi N, Vatay A, Rajczy K, Prohászka Z, Pozsonyi E, Horváth L, Grosz A, Gerõ L, Madácsy L, Romics L, Karádi I, Füst G, Pánczél P.

Diabetes Care. 2003 Feb;26(2):452-7.PMID: 12547879 [PubMed - indexed for MEDLINE]Related articlesFree article

IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity.

Walter M, Albert E, Conrad M, Keller E, Hummel M, Ferber K, Barratt BJ, Todd JA, Ziegler AG, Bonifacio E.

Diabetologia. 2003 May;46(5):712-20. Epub 2003 May 16.PMID: 12750767 [PubMed - indexed for MEDLINE]Related articles