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The experimental type 2 diabetes therapy glycogen phosphorylase inhibition can impair aerobic muscle function during prolonged contraction.

Baker DJ, Greenhaff PL, MacInnes A, Timmons JA.

Diabetes. 2006 Jun;55(6):1855-61.PMID: 16731853 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle.

Baker DJ, Timmons JA, Greenhaff PL.

Diabetes. 2005 Aug;54(8):2453-9.PMID: 16046314 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme.

Freeman S, Bartlett JB, Convey G, Hardern I, Teague JL, Loxham SJ, Allen JM, Poucher SM, Charles AD.

Br J Pharmacol. 2006 Nov;149(6):775-85. Epub 2006 Oct 3.PMID: 17016495 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycogen phosphorylase inhibitors.

Henke BR, Sparks SM.

Mini Rev Med Chem. 2006 Aug;6(8):845-57. Review.PMID: 16918491 [PubMed - indexed for MEDLINE]Related articles

Contraction-mediated glycogenolysis in mouse skeletal muscle lacking creatine kinase: the role of phosphorylase b activation.

Katz A, Andersson DC, Yu J, Norman B, Sandstrom ME, Wieringa B, Westerblad H.

J Physiol. 2003 Dec 1;553(Pt 2):523-31. Epub 2003 Sep 8.PMID: 12963789 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence against glycogen cycling of gluconeogenic substrates in various liver preparations.

Fosgerau K, Breinholt J, McCormack JG, Westergaard N.

J Biol Chem. 2002 Aug 9;277(32):28648-55. Epub 2002 May 31.PMID: 12042303 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycogen phosphorylase as a molecular target for type 2 diabetes therapy.

Oikonomakos NG.

Curr Protein Pept Sci. 2002 Dec;3(6):561-86. Review.PMID: 12470212 [PubMed - indexed for MEDLINE]Related articles

Glutathione-dependent reduction of arsenate by glycogen phosphorylase responsiveness to endogenous and xenobiotic inhibitors.

Gregus Z, Németi B.

Toxicol Sci. 2007 Nov;100(1):44-53. Epub 2007 Aug 9.PMID: 17693424 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-independent glycogen supercompensation in isolated mouse skeletal muscle: role of phosphorylase inactivation.

Sandström ME, Abbate F, Andersson DC, Zhang SJ, Westerblad H, Katz A.

Pflugers Arch. 2004 Aug;448(5):533-8. Epub 2004 Apr 14.PMID: 15085341 [PubMed - indexed for MEDLINE]Related articles

Effect of angiotensin-converting enzyme inhibition on skeletal muscle oxidative function and exercise capacity in streptozotocin-induced diabetic rats.

Rouyer O, Zoll J, Daussin F, Damgé C, Helms P, Talha S, Rasseneur L, Piquard F, Geny B.

Exp Physiol. 2007 Nov;92(6):1047-56. Epub 2007 Aug 3.PMID: 17675412 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.

Zibrova D, Grempler R, Streicher R, Kauschke SG.

Biochem J. 2008 Jun 1;412(2):359-66.PMID: 18298402 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle.

Miyamoto L, Toyoda T, Hayashi T, Yonemitsu S, Nakano M, Tanaka S, Ebihara K, Masuzaki H, Hosoda K, Ogawa Y, Inoue G, Fushiki T, Nakao K.

J Appl Physiol. 2007 Mar;102(3):1007-13. Epub 2006 Nov 22.PMID: 17122373 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARdelta agonism inhibits skeletal muscle PDC activity, mitochondrial ATP production and force generation during prolonged contraction.

Constantin-Teodosiu D, Baker DJ, Constantin D, Greenhaff PL.

J Physiol. 2009 Jan 15;587(Pt 1):231-9. Epub 2008 Nov 10.PMID: 19001043 [PubMed - indexed for MEDLINE]Related articles

The content of glycogen phosphorylase and glycogen in preparations of sarcoplasmic reticulum-glycogenolytic complex is enhanced in diabetic rat skeletal muscle.

Garduño E, Nogues M, Merino JM, Gutiérrez-Merino C, Henao F.

Diabetologia. 2001 Oct;44(10):1238-46.PMID: 11692172 [PubMed - indexed for MEDLINE]Related articles

The effect of a single bout of exhaustive exercise on muscle carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus.

Straczkowski M, Kowalska I, Górski J, Kinalska I.

Acta Diabetol. 2000 Mar;37(1):47-53.PMID: 10928236 [PubMed - indexed for MEDLINE]Related articles

Effects in skeletal muscle.

Young A.

Adv Pharmacol. 2005;52:209-28. Review.PMID: 16492548 [PubMed - indexed for MEDLINE]Related articles

Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats.

Ross RM, Wadley GD, Clark MG, Rattigan S, McConell GK.

Diabetes. 2007 Dec;56(12):2885-92. Epub 2007 Sep 19.PMID: 17881613 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of 7 wk of endurance training on human skeletal muscle metabolism during submaximal exercise.

Leblanc PJ, Howarth KR, Gibala MJ, Heigenhauser GJ.

J Appl Physiol. 2004 Dec;97(6):2148-53. Epub 2004 Jun 25.PMID: 15220302 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetics and anti-hyperglycaemic efficacy of a novel inhibitor of glycogen phosphorylase, 1,4-dideoxy-1,4-imino-d- arabinitol, in glucagon-challenged rats and dogs and in diabetic ob/ob mice.

Mackay P, Ynddal L, Andersen JV, McCormack JG.

Diabetes Obes Metab. 2003 Nov;5(6):397-407.PMID: 14617225 [PubMed - indexed for MEDLINE]Related articles

An acute decrease in TCA cycle intermediates does not affect aerobic energy delivery in contracting rat skeletal muscle.

Dawson KD, Baker DJ, Greenhaff PL, Gibala MJ.

J Physiol. 2005 Jun 1;565(Pt 2):637-43. Epub 2005 Mar 31.PMID: 15802296 [PubMed - indexed for MEDLINE]Related articlesFree article