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    Results: 1 to 20 of 413

    1.

    Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats.

    van Poelje PD, Potter SC, Chandramouli VC, Landau BR, Dang Q, Erion MD.

    Diabetes. 2006 Jun;55(6):1747-54.PMID: 16731838 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.

    Erion MD, van Poelje PD, Dang Q, Kasibhatla SR, Potter SC, Reddy MR, Reddy KR, Jiang T, Lipscomb WN.

    Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5. Epub 2005 May 23.PMID: 15911772 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats.

    Yoshida T, Okuno A, Izumi M, Takahashi K, Hagisawa Y, Ohsumi J, Fujiwara T.

    Eur J Pharmacol. 2008 Dec 28;601(1-3):192-7. Epub 2008 Nov 6.PMID: 19014931 [PubMed - indexed for MEDLINE]Related articles

    4.

    Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes.

    Dang Q, Kasibhatla SR, Reddy KR, Jiang T, Reddy MR, Potter SC, Fujitaki JM, van Poelje PD, Huang J, Lipscomb WN, Erion MD.

    J Am Chem Soc. 2007 Dec 19;129(50):15491-502. Epub 2007 Nov 28.PMID: 18041834 [PubMed - indexed for MEDLINE]Related articles

    5.

    Peroxisome proliferator-activated receptor (PPAR)-alpha agonism prevents the onset of type 2 diabetes in Zucker diabetic fatty rats: A comparison with PPAR gamma agonism.

    Bergeron R, Yao J, Woods JW, Zycband EI, Liu C, Li Z, Adams A, Berger JP, Zhang BB, Moller DE, Doebber TW.

    Endocrinology. 2006 Sep;147(9):4252-62. Epub 2006 May 25.PMID: 16728496 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Recurrent intermittent restraint delays fed and fasting hyperglycemia and improves glucose return to baseline levels during glucose tolerance tests in the Zucker diabetic fatty rat--role of food intake and corticosterone.

    Bates HE, Kiraly MA, Yue JT, Goche Montes D, Elliott ME, Riddell MC, Matthews SG, Vranic M.

    Metabolism. 2007 Aug;56(8):1065-75.PMID: 17618951 [PubMed - indexed for MEDLINE]Related articles

    7.

    Differences in plasma homocysteine levels between Zucker fatty and Zucker diabetic fatty rats following 3 weeks oral administration of organic vanadium compounds.

    Wasan KM, Risovic V, Yuen VG, McNeill JH.

    J Trace Elem Med Biol. 2006;19(4):251-8. Epub 2005 Dec 13.PMID: 16443173 [PubMed - indexed for MEDLINE]Related articles

    8.

    Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats.

    Sudre B, Broqua P, White RB, Ashworth D, Evans DM, Haigh R, Junien JL, Aubert ML.

    Diabetes. 2002 May;51(5):1461-9.PMID: 11978643 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver.

    Visinoni S, Fam BC, Blair A, Rantzau C, Lamont BJ, Bouwman R, Watt MJ, Proietto J, Favaloro JM, Andrikopoulos S.

    Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1132-41. Epub 2008 Sep 9.PMID: 18780768 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats.

    Harmon JS, Gleason CE, Tanaka Y, Poitout V, Robertson RP.

    Diabetes. 2001 Nov;50(11):2481-6.PMID: 11679425 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Modulation of adipoinsular axis in prediabetic zucker diabetic fatty rats by diazoxide.

    Alemzadeh R, Tushaus KM.

    Endocrinology. 2004 Dec;145(12):5476-84. Epub 2004 Aug 19.PMID: 15319354 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin.

    Song S, Andrikopoulos S, Filippis C, Thorburn AW, Khan D, Proietto J.

    Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E275-82.PMID: 11440903 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Topiramate ameliorates hyperglycaemia and improves glucose-stimulated insulin release in ZDF rats and db/db mice.

    Liang Y, Chen X, Osborne M, DeCarlo SO, Jetton TL, Demarest K.

    Diabetes Obes Metab. 2005 Jul;7(4):360-9.PMID: 15955122 [PubMed - indexed for MEDLINE]Related articles

    14.

    Association of insulin resistance with hyperglycemia in streptozotocin-diabetic pigs: effects of metformin at isoenergetic feeding in a type 2-like diabetic pig model.

    Koopmans SJ, Mroz Z, Dekker R, Corbijn H, Ackermans M, Sauerwein H.

    Metabolism. 2006 Jul;55(7):960-71.PMID: 16784971 [PubMed - indexed for MEDLINE]Related articles

    15.

    A nonspecific phosphotyrosine phosphatase inhibitor, bis(maltolato)oxovanadium(IV), improves glucose tolerance and prevents diabetes in Zucker diabetic fatty rats.

    Winter CL, Lange JS, Davis MG, Gerwe GS, Downs TR, Peters KG, Kasibhatla B.

    Exp Biol Med (Maywood). 2005 Mar;230(3):207-16.PMID: 15734724 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Treatment of cardiovascular dysfunction associated with the metabolic syndrome and type 2 diabetes.

    Oltman CL, Kleinschmidt TL, Davidson EP, Coppey LJ, Lund DD, Yorek MA.

    Vascul Pharmacol. 2008 Jan;48(1):47-53. Epub 2007 Nov 29.PMID: 18164667 [PubMed - indexed for MEDLINE]Related articles

    17.

    Preventive effects of a soy-based diet supplemented with stevioside on the development of the metabolic syndrome and type 2 diabetes in Zucker diabetic fatty rats.

    Dyrskog SE, Jeppesen PB, Colombo M, Abudula R, Hermansen K.

    Metabolism. 2005 Sep;54(9):1181-8.PMID: 16125530 [PubMed - indexed for MEDLINE]Related articles

    18.

    Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise.

    Király MA, Bates HE, Yue JT, Goche-Montes D, Fediuc S, Park E, Matthews SG, Vranic M, Riddell MC.

    Metabolism. 2007 Jun;56(6):732-44.PMID: 17512304 [PubMed - indexed for MEDLINE]Related articles

    19.

    The development of overt diabetes in young Zucker Diabetic Fatty (ZDF) rats and the effects of chronic MCC-555 treatment.

    Pickavance L, Widdowson PS, King P, Ishii S, Tanaka H, Williams G.

    Br J Pharmacol. 1998 Oct;125(4):767-70.PMID: 9831913 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Sopungsungi-won (SP) prevents the onset of hyperglycemia and hyperlipidemia in Zucker diabetic fatty rats.

    Kim YY, Kang HJ, Ko SK, Chung SH.

    Arch Pharm Res. 2002 Dec;25(6):923-31.PMID: 12510849 [PubMed - indexed for MEDLINE]Related articles

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