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From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.

Sagen JV, Odili S, Bjørkhaug L, Zelent D, Buettger C, Kwagh J, Stanley C, Dahl-Jørgensen K, de Beaufort C, Bell GI, Han Y, Grimsby J, Taub R, Molven A, Søvik O, Njølstad PR, Matschinsky FM.

Diabetes. 2006 Jun;55(6):1713-22.PMID: 16731834 [PubMed - indexed for MEDLINE]Related articlesFree article

Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM.

J Biol Chem. 2005 Apr 8;280(14):14105-13. Epub 2005 Jan 25.PMID: 15677479 [PubMed - indexed for MEDLINE]Related articlesFree article

Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry.

Sagen JV, Bjørkhaug L, Molnes J, Raeder H, Grevle L, Søvik O, Molven A, Njølstad PR.

Pediatr Diabetes. 2008 Oct;9(5):442-9. Epub 2008 Apr 9.PMID: 18399931 [PubMed - indexed for MEDLINE]Related articles

Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase activity.

García-Herrero CM, Galán M, Vincent O, Flández B, Gargallo M, Delgado-Alvarez E, Blázquez E, Navas MA.

Diabetologia. 2007 Feb;50(2):325-33. Epub 2006 Dec 21.PMID: 17186219 [PubMed - indexed for MEDLINE]Related articles

Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis.

Davis EA, Cuesta-Muñoz A, Raoul M, Buettger C, Sweet I, Moates M, Magnuson MA, Matschinsky FM.

Diabetologia. 1999 Oct;42(10):1175-86.PMID: 10525657 [PubMed - indexed for MEDLINE]Related articles

Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype.

Miller SP, Anand GR, Karschnia EJ, Bell GI, LaPorte DC, Lange AJ.

Diabetes. 1999 Aug;48(8):1645-51.PMID: 10426385 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability.

Galán M, Vincent O, Roncero I, Azriel S, Boix-Pallares P, Delgado-Alvarez E, Díaz-Cadórniga F, Blázquez E, Navas MA.

Biochem J. 2006 Jan 1;393(Pt 1):389-96.PMID: 16173921 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy.

Gloyn AL.

Hum Mutat. 2003 Nov;22(5):353-62. Review.PMID: 14517946 [PubMed - indexed for MEDLINE]Related articles

Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity.

Arden C, Trainer A, de la Iglesia N, Scougall KT, Gloyn AL, Lange AJ, Shaw JA, Matschinsky FM, Agius L.

Diabetes. 2007 Jul;56(7):1773-82. Epub 2007 Mar 27.PMID: 17389332 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2).

Kesavan P, Wang L, Davis E, Cuesta A, Sweet I, Niswender K, Magnuson MA, Matschinsky FM.

Biochem J. 1997 Feb 15;322 ( Pt 1):57-63.PMID: 9078243 [PubMed - indexed for MEDLINE]Related articlesFree article

Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.

Froguel P, Zouali H, Vionnet N, Velho G, Vaxillaire M, Sun F, Lesage S, Stoffel M, Takeda J, Passa P, et al.

N Engl J Med. 1993 Mar 11;328(10):697-702.PMID: 8433729 [PubMed - indexed for MEDLINE]Related articlesFree article

Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.

Heredia VV, Carlson TJ, Garcia E, Sun S.

J Biol Chem. 2006 Dec 29;281(52):40201-7. Epub 2006 Nov 2.PMID: 17082186 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinaemia (GK-HI).

Burke CV, Buettger CW, Davis EA, McClane SJ, Matschinsky FM, Raper SE.

Biochem J. 1999 Sep 1;342 ( Pt 2):345-52.PMID: 10455021 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte.

de la Iglesia N, Mukhtar M, Seoane J, Guinovart JJ, Agius L.

J Biol Chem. 2000 Apr 7;275(14):10597-603.PMID: 10744755 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene.

Tappy L, Dussoix P, Iynedjian P, Henry S, Schneiter P, Zahnd G, Jéquier E, Philippe J.

Diabetes. 1997 Feb;46(2):204-8.PMID: 9000695 [PubMed - indexed for MEDLINE]Related articles

Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.

Gloyn AL, Noordam K, Willemsen MA, Ellard S, Lam WW, Campbell IW, Midgley P, Shiota C, Buettger C, Magnuson MA, Matschinsky FM, Hattersley AT.

Diabetes. 2003 Sep;52(9):2433-40.PMID: 12941786 [PubMed - indexed for MEDLINE]Related articlesFree article

An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism.

Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, Nishimura T, Eiki J, Nagata Y.

J Biol Chem. 2006 Dec 8;281(49):37668-74. Epub 2006 Oct 6.PMID: 17028192 [PubMed - indexed for MEDLINE]Related articlesFree article

Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.

Liang Y, Kesavan P, Wang LQ, Niswender K, Tanizawa Y, Permutt MA, Magnuson MA, Matschinsky FM.

Biochem J. 1995 Jul 1;309 ( Pt 1):167-73.PMID: 7619052 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.

Pino MF, Kim KA, Shelton KD, Lindner J, Odili S, Li C, Collins HW, Shiota M, Matschinsky FM, Magnuson MA.

J Biol Chem. 2007 May 4;282(18):13906-16. Epub 2007 Mar 12.PMID: 17353190 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase mutations in young children with hyperglycemia.

Codner E, Deng L, Pérez-Bravo F, Román R, Lanzano P, Cassorla F, Chung WK.

Diabetes Metab Res Rev. 2006 Sep-Oct;22(5):348-55.PMID: 16444761 [PubMed - indexed for MEDLINE]Related articles