PubMed

Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress.

Menini S, Amadio L, Oddi G, Ricci C, Pesce C, Pugliese F, Giorgio M, Migliaccio E, Pelicci P, Iacobini C, Pugliese G.

Diabetes. 2006 Jun;55(6):1642-50.PMID: 16731826 [PubMed - indexed for MEDLINE]Related articlesFree article

Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation.

Menini S, Iacobini C, Ricci C, Oddi G, Pesce C, Pugliese F, Block K, Abboud HE, Giorgio M, Migliaccio E, Pelicci PG, Pugliese G.

Diabetologia. 2007 Sep;50(9):1997-2007. Epub 2007 Jul 5.PMID: 17611735 [PubMed - indexed for MEDLINE]Related articles

Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.

Camici GG, Schiavoni M, Francia P, Bachschmid M, Martin-Padura I, Hersberger M, Tanner FC, Pelicci P, Volpe M, Anversa P, Lüscher TF, Cosentino F.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5217-22. Epub 2007 Mar 14.PMID: 17360381 [PubMed - indexed for MEDLINE]Related articlesFree article

Glomerular injury is exacerbated in diabetic integrin alpha1-null mice.

Zent R, Yan X, Su Y, Hudson BG, Borza DB, Moeckel GW, Qi Z, Sado Y, Breyer MD, Voziyan P, Pozzi A.

Kidney Int. 2006 Aug;70(3):460-70. Epub 2006 Jun 14.PMID: 16775606 [PubMed - indexed for MEDLINE]Related articles

Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship to oxidative stress.

Pagnin E, Fadini G, de Toni R, Tiengo A, Calò L, Avogaro A.

J Clin Endocrinol Metab. 2005 Feb;90(2):1130-6. Epub 2004 Nov 23.PMID: 15562031 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene.

Rota M, LeCapitaine N, Hosoda T, Boni A, De Angelis A, Padin-Iruegas ME, Esposito G, Vitale S, Urbanek K, Casarsa C, Giorgio M, Lüscher TF, Pelicci PG, Anversa P, Leri A, Kajstura J.

Circ Res. 2006 Jul 7;99(1):42-52. Epub 2006 Jun 8.PMID: 16763167 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

Napoli C, Martin-Padura I, de Nigris F, Giorgio M, Mansueto G, Somma P, Condorelli M, Sica G, De Rosa G, Pelicci P.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2112-6. Epub 2003 Feb 5.PMID: 12571362 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of age-dependent glomerular lesions in galectin-3/AGE-receptor-3 knockout mice.

Iacobini C, Oddi G, Menini S, Amadio L, Ricci C, Di Pippo C, Sorcini M, Pricci F, Pugliese F, Pugliese G.

Am J Physiol Renal Physiol. 2005 Sep;289(3):F611-21. Epub 2005 May 3.PMID: 15870382 [PubMed - indexed for MEDLINE]Related articlesFree article

p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency.

Wolf G, Schanze A, Stahl RA, Shankland SJ, Amann K.

Kidney Int. 2005 Oct;68(4):1583-9.PMID: 16164635 [PubMed - indexed for MEDLINE]Related articles

Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney.

Lee EA, Seo JY, Jiang Z, Yu MR, Kwon MK, Ha H, Lee HB.

Kidney Int. 2005 May;67(5):1762-71.PMID: 15840023 [PubMed - indexed for MEDLINE]Related articles

Galectin-3/AGE-receptor 3 knockout mice show accelerated AGE-induced glomerular injury: evidence for a protective role of galectin-3 as an AGE receptor.

Iacobini C, Menini S, Oddi G, Ricci C, Amadio L, Pricci F, Olivieri A, Sorcini M, Di Mario U, Pesce C, Pugliese G.

FASEB J. 2004 Nov;18(14):1773-5. Epub 2004 Sep 10.PMID: 15361471 [PubMed - indexed for MEDLINE]Related articlesFree article

Early, but not advanced, glomerulopathy is reversed by pancreatic islet transplants in experimental diabetic rats: correlation with glomerular extracellular matrix mRNA levels.

Pugliese G, Pricci F, Pesce C, Romeo G, Lenti E, Caltabiano V, Vetri M, Purrello F, Di Mario U.

Diabetes. 1997 Jul;46(7):1198-206.PMID: 9200656 [PubMed - indexed for MEDLINE]Related articles

Final common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein.

Cosentino F, Francia P, Camici GG, Pelicci PG, Lüscher TF, Volpe M.

Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):622-8. Epub 2007 Dec 27. Review. Erratum in: Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):e154. Volpe, Massimo [added]. PMID: 18162611 [PubMed - indexed for MEDLINE]Related articlesFree article

p66(ShcA) and oxidative stress modulate myogenic differentiation and skeletal muscle regeneration after hind limb ischemia.

Zaccagnini G, Martelli F, Magenta A, Cencioni C, Fasanaro P, Nicoletti C, Biglioli P, Pelicci PG, Capogrossi MC.

J Biol Chem. 2007 Oct 26;282(43):31453-9. Epub 2007 Aug 28.PMID: 17726026 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model.

Meier M, Park JK, Overheu D, Kirsch T, Lindschau C, Gueler F, Leitges M, Menne J, Haller H.

Diabetes. 2007 Feb;56(2):346-54.PMID: 17259378 [PubMed - indexed for MEDLINE]Related articlesFree article

Accelerated nephropathy in diabetic apolipoprotein e-knockout mouse: role of advanced glycation end products.

Lassila M, Seah KK, Allen TJ, Thallas V, Thomas MC, Candido R, Burns WC, Forbes JM, Calkin AC, Cooper ME, Jandeleit-Dahm KA.

J Am Soc Nephrol. 2004 Aug;15(8):2125-38.PMID: 15284298 [PubMed - indexed for MEDLINE]Related articlesFree article

Ras modulation of superoxide activates ERK-dependent fibronectin expression in diabetes-induced renal injuries.

Lin CL, Wang FS, Kuo YR, Huang YT, Huang HC, Sun YC, Kuo YH.

Kidney Int. 2006 May;69(9):1593-600.PMID: 16572112 [PubMed - indexed for MEDLINE]Related articles

Preventing hypoxia/reoxygenation damage to hepatocytes by p66(shc) ablation: up-regulation of anti-oxidant and anti-apoptotic proteins.

Haga S, Terui K, Fukai M, Oikawa Y, Irani K, Furukawa H, Todo S, Ozaki M.

J Hepatol. 2008 Mar;48(3):422-32. Epub 2007 Dec 31.PMID: 18191273 [PubMed - indexed for MEDLINE]Related articles

Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells.

Giunti S, Tesch GH, Pinach S, Burt DJ, Cooper ME, Cavallo-Perin P, Camussi G, Gruden G.

Diabetologia. 2008 Jan;51(1):198-207. Epub 2007 Oct 30.PMID: 17968528 [PubMed - indexed for MEDLINE]Related articles

Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.

Ohshiro Y, Ma RC, Yasuda Y, Hiraoka-Yamamoto J, Clermont AC, Isshiki K, Yagi K, Arikawa E, Kern TS, King GL.

Diabetes. 2006 Nov;55(11):3112-20.PMID: 17065350 [PubMed - indexed for MEDLINE]Related articlesFree article