PubMed

Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat.

Homo-Delarche F, Calderari S, Irminger JC, Gangnerau MN, Coulaud J, Rickenbach K, Dolz M, Halban P, Portha B, Serradas P.

Diabetes. 2006 Jun;55(6):1625-33. Erratum in: Diabetes. 2006 Sep;55(9):2665. PMID: 16731824 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell mass depletion precedes the onset of hyperglycaemia in the GK rat, a genetic model of non-insulin-dependent diabetes mellitus.

Movassat J, Saulnier C, Portha B.

Diabete Metab. 1995 Dec;21(5):365-70.PMID: 8586154 [PubMed - indexed for MEDLINE]Related articles

Increased amounts of a high molecular weight insulin-like growth factor II (IGF-II) peptide and IGF-II messenger ribonucleic acid in pancreatic islets of diabetic Goto-Kakizaki rats.

Höög A, Sandberg-Nordqvist AC, Abdel-Halim SM, Carlsson-Skwirut C, Guenifi A, Tally M, Ostenson CG, Falkmer S, Sara VR, Efendić S, Schalling M, Grimelius L.

Endocrinology. 1996 Jun;137(6):2415-23.PMID: 8641194 [PubMed - indexed for MEDLINE]Related articles

Accelerated loss of islet beta cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus.

Koyama M, Wada R, Sakuraba H, Mizukami H, Yagihashi S.

Am J Pathol. 1998 Aug;153(2):537-45.PMID: 9708813 [PubMed - indexed for MEDLINE]Related articlesFree article

Global expression profiling of glucose-regulated genes in pancreatic islets of spontaneously diabetic Goto-Kakizaki rats.

Ghanaat-Pour H, Huang Z, Lehtihet M, Sjöholm A.

J Mol Endocrinol. 2007 Aug;39(2):135-50.PMID: 17693612 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat.

Ehses JA, Lacraz G, Giroix MH, Schmidlin F, Coulaud J, Kassis N, Irminger JC, Kergoat M, Portha B, Homo-Delarche F, Donath MY.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13998-4003. Epub 2009 Jul 30.PMID: 19666548 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial deoxyribonucleic acid content is specifically decreased in adult, but not fetal, pancreatic islets of the Goto-Kakizaki rat, a genetic model of noninsulin-dependent diabetes.

Serradas P, Giroix MH, Saulnier C, Gangnerau MN, Borg LA, Welsh M, Portha B, Welsh N.

Endocrinology. 1995 Dec;136(12):5623-31.PMID: 7588317 [PubMed - indexed for MEDLINE]Related articles

Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.

Lacraz G, Giroix MH, Kassis N, Coulaud J, Galinier A, Noll C, Cornut M, Schmidlin F, Paul JL, Janel N, Irminger JC, Kergoat M, Portha B, Donath MY, Ehses JA, Homo-Delarche F.

PLoS One. 2009 Sep 9;4(9):e6963.PMID: 19742300 [PubMed - in process]Related articlesFree article

Impaired beta-cell regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of type II diabetes.

Plachot C, Movassat J, Portha B.

Histochem Cell Biol. 2001 Aug;116(2):131-9.PMID: 11685541 [PubMed - indexed for MEDLINE]Related articles

Preserved beta-cell density in the endocrine pancreas of young, spontaneously diabetic Goto-Kakizaki (GK) rats.

Guenifi A, Abdel-Halim SM, Höög A, Falkmer S, Ostenson CG.

Pancreas. 1995 Mar;10(2):148-53.PMID: 7716139 [PubMed - indexed for MEDLINE]Related articles

[Morphological changes of islet of Langerhans in an animal model of type 2 diabetes]

Seiça RM, Martins MJ, Pessa PB, Santos RM, Rosário LM, Suzuki KI, Martins MI.

Acta Med Port. 2003 Nov-Dec;16(6):381-8. Epub 2003 Dec 1. Portuguese. PMID: 15631848 [PubMed - indexed for MEDLINE]Related articles

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

Ihara Y, Toyokuni S, Uchida K, Odaka H, Tanaka T, Ikeda H, Hiai H, Seino Y, Yamada Y.

Diabetes. 1999 Apr;48(4):927-32.PMID: 10102716 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes.

Abdel-Halim SM, Guenifi A, He B, Yang B, Mustafa M, Höjeberg B, Hillert J, Bakhiet M, Efendić S.

Diabetes. 1998 Mar;47(3):498-504.PMID: 9519762 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperglycemia contributes to impaired insulin response in GK rat islets.

Ling ZC, Hong-Lie C, Ostenson CG, Efendic S, Khan A.

Diabetes. 2001 Feb;50 Suppl 1:S108-12.PMID: 11272166 [PubMed - indexed for MEDLINE]Related articles

Type-2 diabetes-induced changes in vascular extracellular matrix gene expression: relation to vessel size.

Song W, Ergul A.

Cardiovasc Diabetol. 2006 Feb 17;5:3.PMID: 16503991 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment.

Gaisano HY, Ostenson CG, Sheu L, Wheeler MB, Efendic S.

Endocrinology. 2002 Nov;143(11):4218-26.PMID: 12399415 [PubMed - indexed for MEDLINE]Related articlesFree article

An early insulin intervention accelerates pancreatic beta-cell dysfunction in young Goto-Kakizaki rats, a model of naturally occurring noninsulin-dependent diabetes.

Suzuki N, Aizawa T, Asanuma N, Sato Y, Komatsu M, Hidaka H, Itoh N, Yamauchi K, Hashizume K.

Endocrinology. 1997 Mar;138(3):1106-10.PMID: 9048616 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of progressive reduction of islet beta-cell mass in spontaneously diabetic Goto-Kakizaki rats by alpha-glucosidase inhibitor.

Koyama M, Wada R, Mizukami H, Sakuraba H, Odaka H, Ikeda H, Yagihashi S.

Metabolism. 2000 Mar;49(3):347-52.PMID: 10726913 [PubMed - indexed for MEDLINE]Related articles

Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes.

Li X, Zhang L, Meshinchi S, Dias-Leme C, Raffin D, Johnson JD, Treutelaar MK, Burant CF.

Diabetes. 2006 Nov;55(11):2965-73.PMID: 17065332 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenylyl cyclase isoform expression in non-diabetic and diabetic Goto-Kakizaki (GK) rat pancreas. Evidence for distinct overexpression of type-8 adenylyl cyclase in diabetic GK rat islets.

Guenifi A, Portela-Gomes GM, Grimelius L, Efendić S, Abdel-Halim SM.

Histochem Cell Biol. 2000 Feb;113(2):81-9.PMID: 10766260 [PubMed - indexed for MEDLINE]Related articles