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    Results: 1 to 20 of 623

    1.

    The role of phosphoinositide 3-kinase/Akt signaling in low-dose mercury-induced mouse pancreatic beta-cell dysfunction in vitro and in vivo.

    Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH.

    Diabetes. 2006 Jun;55(6):1614-24.PMID: 16731823 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Methylmercury induces pancreatic beta-cell apoptosis and dysfunction.

    Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH.

    Chem Res Toxicol. 2006 Aug;19(8):1080-5.PMID: 16918248 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    [High D-glucose alters PI3K and Akt signaling and leads to endothelial cell migration, proliferation and angiogenesis dysfunction]

    Yu P, Yu DM, Qi JC, Wang J, Zhang QM, Zhang JY, Tang YZ, Xing QL, Li MZ.

    Zhonghua Yi Xue Za Zhi. 2006 Dec 26;86(48):3425-30. Chinese. PMID: 17313857 [PubMed - indexed for MEDLINE]Related articles

    4.

    Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.

    Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.

    Endocrinology. 2007 Feb;148(2):512-29. Epub 2006 Oct 26.PMID: 17068144 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Hyperglycemia enhances adipogenic induction of lipid accumulation: involvement of extracellular signal-regulated protein kinase 1/2, phosphoinositide 3-kinase/Akt, and peroxisome proliferator-activated receptor gamma signaling.

    Chuang CC, Yang RS, Tsai KS, Ho FM, Liu SH.

    Endocrinology. 2007 Sep;148(9):4267-75. Epub 2007 May 31.PMID: 17540722 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion.

    Shukla S, Maclennan GT, Hartman DJ, Fu P, Resnick MI, Gupta S.

    Int J Cancer. 2007 Oct 1;121(7):1424-32.PMID: 17551921 [PubMed - indexed for MEDLINE]Related articles

    7.

    Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

    Wente W, Efanov AM, Brenner M, Kharitonenkov A, Köster A, Sandusky GE, Sewing S, Treinies I, Zitzer H, Gromada J.

    Diabetes. 2006 Sep;55(9):2470-8.PMID: 16936195 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion.

    Nogueira TC, Anhê GF, Carvalho CR, Curi R, Bordin S, Carpinelli AR.

    Pancreas. 2008 Oct;37(3):309-15.PMID: 18815554 [PubMed - indexed for MEDLINE]Related articles

    9.

    High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway.

    Sheu ML, Ho FM, Yang RS, Chao KF, Lin WW, Lin-Shiau SY, Liu SH.

    Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):539-45. Epub 2005 Jan 13.PMID: 15653566 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells.

    Lu B, Wang L, Stehlik C, Medan D, Huang C, Hu S, Chen F, Shi X, Rojanasakul Y.

    J Immunol. 2006 Jun 1;176(11):6785-93.PMID: 16709838 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Involvement of insulin/phosphoinositide 3-kinase/Akt signal pathway in 17 beta-estradiol-mediated neuroprotection.

    Yu X, Rajala RV, McGinnis JF, Li F, Anderson RE, Yan X, Li S, Elias RV, Knapp RR, Zhou X, Cao W.

    J Biol Chem. 2004 Mar 26;279(13):13086-94. Epub 2004 Jan 6.PMID: 14711819 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth.

    Zhu QS, Xia L, Mills GB, Lowell CA, Touw IP, Corey SJ.

    Blood. 2006 Mar 1;107(5):1847-56. Epub 2005 Nov 10.PMID: 16282349 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Insulin growth factor 1 receptor/PI3K/AKT survival pathway in outer segment membranes of rod photoreceptors.

    Dilly AK, Rajala RV.

    Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4765-73. Epub 2008 Jun 19.PMID: 18566464 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways.

    Hu Y, Chen X, Pan TT, Neo KL, Lee SW, Khin ES, Moore PK, Bian JS.

    Pflugers Arch. 2008 Jan;455(4):607-16. Epub 2007 Aug 1.PMID: 17674030 [PubMed - indexed for MEDLINE]Related articles

    15.

    Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression.

    Kim SJ, Winter K, Nian C, Tsuneoka M, Koda Y, McIntosh CH.

    J Biol Chem. 2005 Jun 10;280(23):22297-307. Epub 2005 Apr 6.PMID: 15817464 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Glial cell line-derived neurotrophic factor increases beta-cell mass and improves glucose tolerance.

    Mwangi S, Anitha M, Mallikarjun C, Ding X, Hara M, Parsadanian A, Larsen CP, Thule P, Sitaraman SV, Anania F, Srinivasan S.

    Gastroenterology. 2008 Mar;134(3):727-37. Epub 2008 Feb 1.PMID: 18241861 [PubMed - indexed for MEDLINE]Related articles

    17.

    Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cell.

    Martinez SC, Cras-Méneur C, Bernal-Mizrachi E, Permutt MA.

    Diabetes. 2006 Jun;55(6):1581-91.PMID: 16731820 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation.

    He L, Simmen FA, Mehendale HM, Ronis MJ, Badger TM.

    J Biol Chem. 2006 Apr 21;281(16):11126-34. Epub 2006 Feb 1.PMID: 16452480 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells.

    Li B, Cheung PY, Wang X, Tsao SW, Ling MT, Wong YC, Cheung AL.

    Carcinogenesis. 2007 Nov;28(11):2313-20. Epub 2007 Jul 16.PMID: 17638919 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.

    Bouzakri K, Ribaux P, Tomas A, Parnaud G, Rickenbach K, Halban PA.

    Diabetes. 2008 May;57(5):1195-204. Epub 2008 Feb 14.PMID: 18276765 [PubMed - indexed for MEDLINE]Related articlesFree article

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