PubMed

Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.

Lalloyer F, Vandewalle B, Percevault F, Torpier G, Kerr-Conte J, Oosterveer M, Paumelle R, Fruchart JC, Kuipers F, Pattou F, Fiévet C, Staels B.

Diabetes. 2006 Jun;55(6):1605-13.PMID: 16731822 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha).

Bihan H, Rouault C, Reach G, Poitout V, Staels B, Guerre-Millo M.

FEBS Lett. 2005 Apr 25;579(11):2284-8.PMID: 15848159 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate.

Sun Y, Zhang L, Gu HF, Han W, Ren M, Wang F, Gong B, Wang L, Guo H, Xin W, Zhao J, Gao L.

Endocrinology. 2008 Feb;149(2):662-71. Epub 2007 Nov 8.PMID: 17991720 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation.

Gremlich S, Nolan C, Roduit R, Burcelin R, Peyot ML, Delghingaro-Augusto V, Desvergne B, Michalik L, Prentki M, Wahli W.

Endocrinology. 2005 Jan;146(1):375-82. Epub 2004 Sep 30.PMID: 15459119 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet.

Matsui J, Terauchi Y, Kubota N, Takamoto I, Eto K, Yamashita T, Komeda K, Yamauchi T, Kamon J, Kita S, Noda M, Kadowaki T.

Diabetes. 2004 Nov;53(11):2844-54.PMID: 15504964 [PubMed - indexed for MEDLINE]Related articlesFree article

AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats.

Ljung B, Bamberg K, Dahllöf B, Kjellstedt A, Oakes ND, Ostling J, Svensson L, Camejo G.

J Lipid Res. 2002 Nov;43(11):1855-63.PMID: 12401884 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.

Ravnskjaer K, Boergesen M, Rubi B, Larsen JK, Nielsen T, Fridriksson J, Maechler P, Mandrup S.

Endocrinology. 2005 Aug;146(8):3266-76. Epub 2005 May 5.PMID: 15878969 [PubMed - indexed for MEDLINE]Related articlesFree article

PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance.

Guerre-Millo M, Rouault C, Poulain P, André J, Poitout V, Peters JM, Gonzalez FJ, Fruchart JC, Reach G, Staels B.

Diabetes. 2001 Dec;50(12):2809-14.PMID: 11723064 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute (24 h) activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets.

Holness MJ, Smith ND, Greenwood GK, Sugden MC.

J Endocrinol. 2003 May;177(2):197-205.PMID: 12740007 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvement of dyslipidemia, insulin sensitivity, and energy balance by a peroxisome proliferator-activated receptor alpha agonist.

Chen X, Matthews J, Zhou L, Pelton P, Liang Y, Xu J, Yang M, Cryan E, Rybczynski P, Demarest K.

Metabolism. 2008 Nov;57(11):1516-25.PMID: 18940388 [PubMed - indexed for MEDLINE]Related articles

The dual peroxisome proliferator-activated receptor alpha/gamma activator muraglitazar prevents the natural progression of diabetes in db/db mice.

Tozzo E, Ponticiello R, Swartz J, Farrelly D, Zebo R, Welzel G, Egan D, Kunselman L, Peters A, Gu L, French M, Chen S, Devasthale P, Janovitz E, Staal A, Harrity T, Belder R, Cheng PT, Whaley J, Taylor S, Hariharan N.

J Pharmacol Exp Ther. 2007 Apr;321(1):107-15. Epub 2007 Jan 26.PMID: 17259449 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved glucose and lipid metabolism in genetically obese mice lacking aP2.

Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS.

Endocrinology. 2000 Sep;141(9):3388-96.PMID: 10965911 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice.

Park CW, Zhang Y, Zhang X, Wu J, Chen L, Cha DR, Su D, Hwang MT, Fan X, Davis L, Striker G, Zheng F, Breyer M, Guan Y.

Kidney Int. 2006 May;69(9):1511-7.PMID: 16672921 [PubMed - indexed for MEDLINE]Related articles

PAR-5359, a well-balanced PPARalpha/gamma dual agonist, exhibits equivalent antidiabetic and hypolipidemic activities in vitro and in vivo.

Kim MK, Chae YN, Son MH, Kim SH, Kim JK, Moon HS, Park CS, Bae MH, Kim E, Han T, Choi HH, Shin YA, Ahn BN, Lee CH, Lim JI, Shin CY.

Eur J Pharmacol. 2008 Oct 24;595(1-3):119-25. Epub 2008 Aug 12.PMID: 18727927 [PubMed - indexed for MEDLINE]Related articles

Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice.

Verreth W, De Keyzer D, Pelat M, Verhamme P, Ganame J, Bielicki JK, Mertens A, Quarck R, Benhabilès N, Marguerie G, Mackness B, Mackness M, Ninio E, Herregods MC, Balligand JL, Holvoet P.

Circulation. 2004 Nov 16;110(20):3259-69. Epub 2004 Nov 8.PMID: 15533870 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell.

Roduit R, Morin J, Massé F, Segall L, Roche E, Newgard CB, Assimacopoulos-Jeannet F, Prentki M.

J Biol Chem. 2000 Nov 17;275(46):35799-806.PMID: 10967113 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced repression of PPARalpha gene expression in pancreatic beta-cells involves PP2A activation and AMPK inactivation.

Ravnskjaer K, Boergesen M, Dalgaard LT, Mandrup S.

J Mol Endocrinol. 2006 Apr;36(2):289-99.PMID: 16595700 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of insulin signaling through inhibition of tissue lipid accumulation by activation of peroxisome proliferator-activated receptor (PPAR) alpha in obese mice.

Ide T, Tsunoda M, Mochizuki T, Murakami K.

Med Sci Monit. 2004 Oct;10(10):BR388-95. Epub 2004 Sep 23.PMID: 15448592 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet.

Cha DR, Han JY, Su DM, Zhang Y, Fan X, Breyer MD, Guan Y.

Am J Nephrol. 2007;27(5):479-82. Epub 2007 Jul 25.PMID: 17652964 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.

Lupi R, Del Guerra S, Marselli L, Bugliani M, Boggi U, Mosca F, Marchetti P, Del Prato S.

Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E560-7. Epub 2003 Nov 18.PMID: 14625208 [PubMed - indexed for MEDLINE]Related articlesFree article