PubMed

Lymphocytic infiltration and immune activation in metallothionein promoter-exendin-4 (MT-Exendin) transgenic mice.

Baggio LL, Holland D, Wither J, Drucker DJ.

Diabetes. 2006 Jun;55(6):1562-70.PMID: 16731818 [PubMed - indexed for MEDLINE]Related articlesFree article

Sustained expression of exendin-4 does not perturb glucose homeostasis, beta-cell mass, or food intake in metallothionein-preproexendin transgenic mice.

Baggio L, Adatia F, Bock T, Brubaker PL, Drucker DJ.

J Biol Chem. 2000 Nov 3;275(44):34471-7.PMID: 10952981 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo.

Baggio LL, Kim JG, Drucker DJ.

Diabetes. 2004 Dec;53 Suppl 3:S205-14.PMID: 15561912 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular specificity of proexendin-4 processing in mammalian cells in vitro and in vivo.

Adatia FA, Baggio LL, Xiao Q, Drucker DJ, Brubaker PL.

Endocrinology. 2002 Sep;143(9):3464-71.PMID: 12193559 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 modulates diabetes onset in nonobese diabetic mice.

Hadjiyanni I, Baggio LL, Poussier P, Drucker DJ.

Endocrinology. 2008 Mar;149(3):1338-49. Epub 2007 Dec 6.PMID: 18063685 [PubMed - indexed for MEDLINE]Related articlesFree article

A new orally available glucagon-like peptide-1 receptor agonist, biotinylated exendin-4, displays improved hypoglycemic effects in db/db mice.

Jin CH, Chae SY, Son S, Kim TH, Um KA, Youn YS, Lee S, Lee KC.

J Control Release. 2009 Feb 10;133(3):172-7. Epub 2008 Oct 21.PMID: 18977255 [PubMed - indexed for MEDLINE]Related articles

An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis.

Baggio LL, Huang Q, Cao X, Drucker DJ.

Gastroenterology. 2008 Apr;134(4):1137-47. Epub 2008 Jan 11.PMID: 18313669 [PubMed - indexed for MEDLINE]Related articles

[Lys40(Ahx-DTPA-111In)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targeting.

Wild D, Béhé M, Wicki A, Storch D, Waser B, Gotthardt M, Keil B, Christofori G, Reubi JC, Mäcke HR.

J Nucl Med. 2006 Dec;47(12):2025-33.PMID: 17138746 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific expression of unique mRNAs that encode proglucagon-derived peptides or exendin 4 in the lizard.

Chen YE, Drucker DJ.

J Biol Chem. 1997 Feb 14;272(7):4108-15.PMID: 9020121 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells.

Perry T, Lahiri DK, Chen D, Zhou J, Shaw KT, Egan JM, Greig NH.

J Pharmacol Exp Ther. 2002 Mar;300(3):958-66.PMID: 11861804 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of action of glucagon-like peptide 1 in the pancreas.

Doyle ME, Egan JM.

Pharmacol Ther. 2007 Mar;113(3):546-93. Epub 2006 Dec 28. Review.PMID: 17306374 [PubMed - indexed for MEDLINE]Related articlesFree article

A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis.

Baggio LL, Huang Q, Brown TJ, Drucker DJ.

Diabetes. 2004 Sep;53(9):2492-500.PMID: 15331566 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice.

Ding X, Saxena NK, Lin S, Gupta NA, Anania FA.

Hepatology. 2006 Jan;43(1):173-81. Erratum in: Hepatology. 2006 Aug;44(2):515. Gupta, Narita [corrected to Gupta, Nitika Arora]. PMID: 16374859 [PubMed - indexed for MEDLINE]Related articles

Durable islet effects on insulin secretion and protein kinase A expression following exendin-4 treatment of high-fat diet-fed mice.

Winzell MS, Ahrén B.

J Mol Endocrinol. 2008 Feb;40(2):93-100.PMID: 18234911 [PubMed - indexed for MEDLINE]Related articlesFree article

The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1.

López de Maturana R, Willshaw A, Kuntzsch A, Rudolph R, Donnelly D.

J Biol Chem. 2003 Mar 21;278(12):10195-200. Epub 2003 Jan 10.PMID: 12524435 [PubMed - indexed for MEDLINE]Related articlesFree article

A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors.

Al-Sabah S, Donnelly D.

Br J Pharmacol. 2003 Sep;140(2):339-46. Epub 2003 Aug 26.PMID: 12970080 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice.

Park CW, Kim HW, Ko SH, Lim JH, Ryu GR, Chung HW, Han SW, Shin SJ, Bang BK, Breyer MD, Chang YS.

J Am Soc Nephrol. 2007 Apr;18(4):1227-38. Epub 2007 Mar 14.PMID: 17360951 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.

Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC.

Endocrinology. 2007 Nov;148(11):5136-44. Epub 2007 Aug 2.PMID: 17673522 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice.

Koehler JA, Baggio LL, Lamont BJ, Ali S, Drucker DJ.

Diabetes. 2009 Sep;58(9):2148-61. Epub 2009 Jun 9.PMID: 19509017 [PubMed - indexed for MEDLINE]Related articlesFree article

[Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 is a highly efficient radiotherapeutic for glucagon-like peptide-1 receptor-targeted therapy for insulinoma.

Wicki A, Wild D, Storch D, Seemayer C, Gotthardt M, Behe M, Kneifel S, Mihatsch MJ, Reubi JC, Mäcke HR, Christofori G.

Clin Cancer Res. 2007 Jun 15;13(12):3696-705.PMID: 17575235 [PubMed - indexed for MEDLINE]Related articlesFree article