PubMed

Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice.

Carty NC, Wilcock DM, Rosenthal A, Grimm J, Pons J, Ronan V, Gottschall PE, Gordon MN, Morgan D.

J Neuroinflammation. 2006 May 10;3:11.PMID: 16686956 [PubMed]Related articlesFree article

Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation.

Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, Ugen KE, Gordon MN, Morgan D.

J Neurosci. 2003 May 1;23(9):3745-51.PMID: 12736345 [PubMed - indexed for MEDLINE]Related articlesFree article

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

Wilcock DM, Rojiani A, Rosenthal A, Levkowitz G, Subbarao S, Alamed J, Wilson D, Wilson N, Freeman MJ, Gordon MN, Morgan D.

J Neurosci. 2004 Jul 7;24(27):6144-51.PMID: 15240806 [PubMed - indexed for MEDLINE]Related articlesFree article

Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice.

Wilcock DM, Alamed J, Gottschall PE, Grimm J, Rosenthal A, Pons J, Ronan V, Symmonds K, Gordon MN, Morgan D.

J Neurosci. 2006 May 17;26(20):5340-6.PMID: 16707786 [PubMed - indexed for MEDLINE]Related articlesFree article

Deglycosylated anti-Abeta antibody dose-response effects on pathology and memory in APP transgenic mice.

Karlnoski RA, Rosenthal A, Alamed J, Ronan V, Gordon MN, Gottschall PE, Grimm J, Pons J, Morgan D.

J Neuroimmune Pharmacol. 2008 Sep;3(3):187-97. Epub 2008 Jul 8.PMID: 18607758 [PubMed - indexed for MEDLINE]Related articles

Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration.

Takata K, Hirata-Fukae C, Becker AG, Chishiro S, Gray AJ, Nishitomi K, Franz AH, Sakaguchi G, Kato A, Mattson MP, Laferla FM, Aisen PS, Kitamura Y, Matsuoka Y.

Eur J Neurosci. 2007 Nov;26(9):2458-68. Epub 2007 Oct 23.PMID: 17970733 [PubMed - indexed for MEDLINE]Related articles

Microglial activation is required for Abeta clearance after intracranial injection of lipopolysaccharide in APP transgenic mice.

Herber DL, Mercer M, Roth LM, Symmonds K, Maloney J, Wilson N, Freeman MJ, Morgan D, Gordon MN.

J Neuroimmune Pharmacol. 2007 Jun;2(2):222-31. Epub 2007 Mar 27.PMID: 18040847 [PubMed - indexed for MEDLINE]Related articles

Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice.

Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman DM.

J Neurosci. 2008 Dec 24;28(52):14156-64.PMID: 19109498 [PubMed - indexed for MEDLINE]Related articlesFree article

Contrasting in vivo effects of two peptide-based amyloid-beta protein aggregation inhibitors in a transgenic mouse model of amyloid deposition.

Li Q, Gordon M, Etienne MA, Hammer RP, Morgan D.

Cell Transplant. 2008;17(4):397-408.PMID: 18522242 [PubMed - indexed for MEDLINE]Related articles

Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration.

Wilcock DM, Munireddy SK, Rosenthal A, Ugen KE, Gordon MN, Morgan D.

Neurobiol Dis. 2004 Feb;15(1):11-20.PMID: 14751766 [PubMed - indexed for MEDLINE]Related articles

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice.

Maier M, Peng Y, Jiang L, Seabrook TJ, Carroll MC, Lemere CA.

J Neurosci. 2008 Jun 18;28(25):6333-41.PMID: 18562603 [PubMed - indexed for MEDLINE]Related articlesFree article

High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain.

Güntert A, Döbeli H, Bohrmann B.

Neuroscience. 2006 Dec 1;143(2):461-75. Epub 2006 Sep 27.PMID: 17008022 [PubMed - indexed for MEDLINE]Related articles

The role of microglia in antibody-mediated clearance of amyloid-beta from the brain.

Morgan D.

CNS Neurol Disord Drug Targets. 2009 Mar;8(1):7-15. Review.PMID: 19275633 [PubMed - indexed for MEDLINE]Related articles

Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease.

Dutescu RM, Li QX, Crowston J, Masters CL, Baird PN, Culvenor JG.

Graefes Arch Clin Exp Ophthalmol. 2009 Sep;247(9):1213-21. Epub 2009 Mar 7.PMID: 19271231 [PubMed - indexed for MEDLINE]Related articles

Visualization of brain amyloid and microglial activation in mouse models of Alzheimer's disease.

Higuchi M.

Curr Alzheimer Res. 2009 Apr;6(2):137-43.PMID: 19355848 [PubMed - indexed for MEDLINE]Related articles

Viral-induced inflammation is accompanied by beta-amyloid plaque reduction in brains of amyloid precursor protein transgenic Tg2576 mice.

Stahl T, Reimers C, Johne R, Schliebs R, Seeger J.

Eur J Neurosci. 2006 Oct;24(7):1923-34.PMID: 17067295 [PubMed - indexed for MEDLINE]Related articles

Deglycosylation of anti-beta amyloid antibodies inhibits microglia activation in BV-2 cellular model.

Rebe S, Solomon B.

Am J Alzheimers Dis Other Demen. 2005 Sep-Oct;20(5):303-13.PMID: 16273996 [PubMed - indexed for MEDLINE]Related articles

Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice.

Petrushina I, Ghochikyan A, Mkrtichyan M, Mamikonyan G, Movsesyan N, Ajdari R, Vasilevko V, Karapetyan A, Lees A, Agadjanyan MG, Cribbs DH.

J Neuroinflammation. 2008 Sep 29;5:42.PMID: 18823564 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of microglial activation state following passive immunization in amyloid depositing transgenic mice.

Morgan D.

Neurochem Int. 2006 Jul;49(2):190-4. Epub 2006 Jun 5. Review.PMID: 16740342 [PubMed - indexed for MEDLINE]Related articles

Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg2576 mice without a significant effect on brain abeta levels.

Rakover I, Arbel M, Solomon B.

Neurodegener Dis. 2007;4(5):392-402. Epub 2007 May 25.PMID: 17536186 [PubMed - indexed for MEDLINE]Related articles