PubMed

Elevated activity of transcription factor nuclear factor of activated T-cells 5 (NFAT5) and diabetic nephropathy.

Yang B, Hodgkinson AD, Oates PJ, Kwon HM, Millward BA, Demaine AG.

Diabetes. 2006 May;55(5):1450-5.PMID: 16644704 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose induction of DNA-binding activity of the transcription factor NFkappaB in patients with diabetic nephropathy.

Yang B, Hodgkinson A, Oates PJ, Millward BA, Demaine AG.

Biochim Biophys Acta. 2008 May;1782(5):295-302. Epub 2008 Feb 15.PMID: 18325349 [PubMed - indexed for MEDLINE]Related articles

Characterization of the osmotic response element of the human aldose reductase gene promoter.

Ruepp B, Bohren KM, Gabbay KH.

Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8624-9.PMID: 8710921 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase expression is induced by hyperglycemia in diabetic nephropathy.

Hodgkinson AD, Søndergaard KL, Yang B, Cross DF, Millward BA, Demaine AG.

Kidney Int. 2001 Jul;60(1):211-8.PMID: 11422753 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes mellitus increases endothelin-1 gene transcription in rat kidney.

Hargrove GM, Dufresne J, Whiteside C, Muruve DA, Wong NC.

Kidney Int. 2000 Oct;58(4):1534-45.PMID: 11012888 [PubMed - indexed for MEDLINE]Related articlesFree article

The response of antioxidant genes to hyperglycemia is abnormal in patients with type 1 diabetes and diabetic nephropathy.

Hodgkinson AD, Bartlett T, Oates PJ, Millward BA, Demaine AG.

Diabetes. 2003 Mar;52(3):846-51.PMID: 12606529 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control.

Langham RG, Kelly DJ, Gow RM, Zhang Y, Cox AJ, Qi W, Thai K, Pollock CA, Christensen PK, Parving HH, Gilbert RE.

Diabetologia. 2008 Apr;51(4):668-74. Epub 2008 Feb 16.PMID: 18278479 [PubMed - indexed for MEDLINE]Related articles

Control of sorbitol metabolism in renal inner medulla of diabetic rats: regulation by substrate, cosubstrate and products of the aldose reductase reaction.

Grunewald RW, Weber II, Kinne-Saffran E, Kinne RK.

Biochim Biophys Acta. 1993 Nov 25;1225(1):39-47.PMID: 8241288 [PubMed - indexed for MEDLINE]Related articles

Induction of aldose reductase in cultured human microvascular endothelial cells by advanced glycation end products.

Nakamura N, Obayashi H, Fujii M, Fukui M, Yoshimori K, Ogata M, Hasegawa G, Shigeta H, Kitagawa Y, Yoshikawa T, Kondo M, Ohta M, Nishimura M, Nishinaka T, Nishimura CY.

Free Radic Biol Med. 2000 Jul 1;29(1):17-25.PMID: 10962201 [PubMed - indexed for MEDLINE]Related articles

Enhanced expression of group IIA secreted phospholipase A2 by elevated glucose levels in cytokine-stimulated rat mesangial cells and in kidneys of diabetic rats.

Vlachojannis GJ, Scholz-Pedretti K, Fierlbeck W, Geiger H, Pfeilschifter J, Kaszkin M.

Clin Nephrol. 2005 May;63(5):356-67.PMID: 15909595 [PubMed - indexed for MEDLINE]Related articles

Crucial role of aldose reductase activity and plasma glucose level in sorbitol accumulation in erythrocytes from diabetic patients.

Hamada Y, Kitoh R, Raskin P.

Diabetes. 1991 Oct;40(10):1233-40.PMID: 1936586 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms of the glucose transporter (GLUT1) gene are associated with diabetic nephropathy.

Hodgkinson AD, Millward BA, Demaine AG.

Kidney Int. 2001 Mar;59(3):985-9.PMID: 11231353 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of rat aldose reductase gene transcription is mediated through the cis-element, osmotic response element (ORE): increased synthesis and/or activation by phosphorylation of ORE-binding protein is a key step.

Aida K, Tawata M, Ikegishi Y, Onaya T.

Endocrinology. 1999 Feb;140(2):609-17.PMID: 9927284 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased white cell aldose reductase mRNA levels in diabetic patients.

Kicic E, Palmer TN.

Diabetes Res Clin Pract. 1996 Jun;33(1):31-6.PMID: 8877273 [PubMed - indexed for MEDLINE]Related articles

Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience.

Nayak B, Xie P, Akagi S, Yang Q, Sun L, Wada J, Thakur A, Danesh FR, Chugh SS, Kanwar YS.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17952-7. Epub 2005 Dec 5.PMID: 16330753 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphism in the 5'-end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in type I diabetes.

Heesom AE, Hibberd ML, Millward A, Demaine AG.

Diabetes. 1997 Feb;46(2):287-91.PMID: 9000706 [PubMed - indexed for MEDLINE]Related articles

Influence of renal involvement on peripheral blood mononuclear cell expression behaviour of tumour necrosis factor-alpha and interleukin-6 in type 2 diabetic patients.

Navarro JF, Mora C, Gómez M, Muros M, López-Aguilar C, García J.

Nephrol Dial Transplant. 2008 Mar;23(3):919-26. Epub 2007 Oct 2.PMID: 17911088 [PubMed - indexed for MEDLINE]Related articles

Association of glomerulopathy with the 5'-end polymorphism of the aldose reductase gene and renal insufficiency in type 2 diabetic patients.

Zhao HL, Tong PC, Lai FM, Tomlinson B, Chan JC.

Diabetes. 2004 Nov;53(11):2984-91.PMID: 15504980 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells.

Drel VR, Pacher P, Stevens MJ, Obrosova IG.

Free Radic Biol Med. 2006 Apr 15;40(8):1454-65. Epub 2006 Jan 31.PMID: 16631535 [PubMed - indexed for MEDLINE]Related articlesFree article

(AC)(n) polymorphism of aldose reductase gene and diabetic microvascular complications in type 2 diabetes mellitus.

Park HK, Ahn CW, Lee GT, Kim SJ, Song YD, Lim SK, Kim KR, Huh KB, Lee HC.

Diabetes Res Clin Pract. 2002 Feb;55(2):151-7.PMID: 11796181 [PubMed - indexed for MEDLINE]Related articles