PubMed

Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines.

Collier JJ, Fueger PT, Hohmeier HE, Newgard CB.

Diabetes. 2006 May;55(5):1398-406.PMID: 16644697 [PubMed - indexed for MEDLINE]Related articlesFree article

Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis.

Van de Casteele M, Kefas BA, Ling Z, Heimberg H, Pipeleers DG.

Endocrinology. 2002 Jan;143(1):320-6.PMID: 11751624 [PubMed - indexed for MEDLINE]Related articlesFree article

Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.

Rabinovitch A, Suarez-Pinzon W, Strynadka K, Ju Q, Edelstein D, Brownlee M, Korbutt GS, Rajotte RV.

Diabetes. 1999 Jun;48(6):1223-9.PMID: 10342808 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.

Li L, El-Kholy W, Rhodes CJ, Brubaker PL.

Diabetologia. 2005 Jul;48(7):1339-49. Epub 2005 May 19.PMID: 15902400 [PubMed - indexed for MEDLINE]Related articles

Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling.

Ling Z, Van de Casteele M, Dong J, Heimberg H, Haefliger JA, Waeber G, Schuit F, Pipeleers D.

Diabetes. 2003 Oct;52(10):2497-502.PMID: 14514632 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of calbindin-D(28k) in a pancreatic islet beta-cell line protects against cytokine-induced apoptosis and necrosis.

Rabinovitch A, Suarez-Pinzon WL, Sooy K, Strynadka K, Christakos S.

Endocrinology. 2001 Aug;142(8):3649-55.PMID: 11459814 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells.

Jambal P, Masterson S, Nesterova A, Bouchard R, Bergman B, Hutton JC, Boxer LM, Reusch JE, Pugazhenthi S.

J Biol Chem. 2003 Jun 20;278(25):23055-65. Epub 2003 Apr 5.PMID: 12679364 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

Piro S, Anello M, Di Pietro C, Lizzio MN, Patanè G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F.

Metabolism. 2002 Oct;51(10):1340-7.PMID: 12370856 [PubMed - indexed for MEDLINE]Related articles

High glucose potentiates cytokine- and streptozotocin-induced apoptosis of rat islet cells: effect on apoptosis-related genes.

Mellado-Gil JM, Aguilar-Diosdado M.

J Endocrinol. 2004 Oct;183(1):155-62.PMID: 15525583 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells.

Han X, Sun Y, Scott S, Bleich D.

Diabetes. 2001 May;50(5):1047-55.PMID: 11334407 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL.

Holohan C, Szegezdi E, Ritter T, O'Brien T, Samali A.

J Cell Mol Med. 2008 Apr;12(2):591-606. Epub 2007 Dec 10.PMID: 18081694 [PubMed - indexed for MEDLINE]Related articles

The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic beta cells.

Haefliger JA, Tawadros T, Meylan L, Gurun SL, Roehrich ME, Martin D, Thorens B, Waeber G.

J Cell Sci. 2003 Apr 15;116(Pt 8):1463-9.PMID: 12640031 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of interleukin-15 on suppression of rat pancreatic islets in vitro induced by proinflammatory cytokines.

Wallström J, Andersson AK, Sandler S.

Immunol Lett. 2003 Aug 5;88(2):141-5.PMID: 12880684 [PubMed - indexed for MEDLINE]Related articles

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.PMID: 15297438 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity.

Chen M, Yang ZD, Smith KM, Carter JD, Nadler JL.

Diabetologia. 2005 Mar;48(3):486-95. Epub 2005 Feb 24.PMID: 15729574 [PubMed - indexed for MEDLINE]Related articles

Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy.

Tran VV, Chen G, Newgard CB, Hohmeier HE.

Diabetes. 2003 Jun;52(6):1423-32.PMID: 12765953 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity.

Riboulet-Chavey A, Diraison F, Siew LK, Wong FS, Rutter GA.

Diabetes. 2008 Feb;57(2):415-23. Epub 2007 Nov 14.PMID: 18003756 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor.

Chong MM, Thomas HE, Kay TW.

J Biol Chem. 2002 Aug 2;277(31):27945-52. Epub 2002 May 24.PMID: 12032139 [PubMed - indexed for MEDLINE]Related articlesFree article

A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets.

Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C.

J Exp Med. 1999 Oct 18;190(8):1135-46.PMID: 10523611 [PubMed - indexed for MEDLINE]Related articlesFree article

Destruction of rat pancreatic islet beta-cells by cytokines involves the production of cytotoxic aldehydes.

Suarez-Pinzon WL, Strynadka K, Rabinovitch A.

Endocrinology. 1996 Dec;137(12):5290-6.PMID: 8940348 [PubMed - indexed for MEDLINE]Related articles