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Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA.

López M, Lelliott CJ, Tovar S, Kimber W, Gallego R, Virtue S, Blount M, Vázquez MJ, Finer N, Powles TJ, O'Rahilly S, Saha AK, Diéguez C, Vidal-Puig AJ.

Diabetes. 2006 May;55(5):1327-36.PMID: 16644689 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of malonyl-CoA in the hypothalamic control of food intake and energy expenditure.

Lane MD, Hu Z, Cha SH, Dai Y, Wolfgang M, Sidhaye A.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1063-7.PMID: 16246046 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic malonyl-CoA as a mediator of feeding behavior.

Hu Z, Cha SH, Chohnan S, Lane MD.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12624-9. Epub 2003 Oct 7.PMID: 14532332 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschöp MH, Diéguez C, Vidal-Puig A.

Cell Metab. 2008 May;7(5):389-99.PMID: 18460330 [PubMed - indexed for MEDLINE]Related articles

Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis.

Lelliott CJ, López M, Curtis RK, Parker N, Laudes M, Yeo G, Jimenez-Liñan M, Grosse J, Saha AK, Wiggins D, Hauton D, Brand MD, O'Rahilly S, Griffin JL, Gibbons GF, Vidal-Puig A.

FASEB J. 2005 Jul;19(9):1108-19.PMID: 15985534 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle.

Cha SH, Hu Z, Chohnan S, Lane MD.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14557-62. Epub 2005 Oct 3.PMID: 16203972 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis.

Menendez JA, Colomer R, Lupu R.

Med Hypotheses. 2005;64(2):337-41.PMID: 15607568 [PubMed - indexed for MEDLINE]Related articles

In vivo IL-1beta-induced modulation of G-protein alphaO subunit subclass in the hypothalamic ventromedial nucleus: implications to IL-1beta-associated anorexia.

Plata-Salamán CR, Wilson CD, Ffrench-Mullen JM.

Brain Res Mol Brain Res. 1998 Jul 15;58(1-2):188-94.PMID: 9685638 [PubMed - indexed for MEDLINE]Related articles

Influence of feeding status on neuronal activity in the hypothalamus during lipopolysaccharide-induced anorexia in rats.

Gautron L, Mingam R, Moranis A, Combe C, Layé S.

Neuroscience. 2005;134(3):933-46.PMID: 16039792 [PubMed - indexed for MEDLINE]Related articles

A role for hypothalamic malonyl-CoA in the control of food intake.

Hu Z, Dai Y, Prentki M, Chohnan S, Lane MD.

J Biol Chem. 2005 Dec 2;280(48):39681-3. Epub 2005 Oct 11.PMID: 16219771 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of hypothalamic malonyl-CoA in energy homeostasis.

Wolfgang MJ, Lane MD.

J Biol Chem. 2006 Dec 8;281(49):37265-9. Epub 2006 Oct 3. Review.PMID: 17018521 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors.

Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, Kuhajda FP.

Science. 2000 Jun 30;288(5475):2379-81.PMID: 10875926 [PubMed - indexed for MEDLINE]Related articlesFree article

FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens.

Dridi S, Ververken C, Hillgartner FB, Arckens L, Van der Gucht E, Cnops L, Decuypere E, Buyse J.

Am J Physiol Regul Integr Comp Physiol. 2006 Jul;291(1):R138-47. Epub 2006 Feb 2. Erratum in: Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R860. Lutgarde, Arckens [corrected to Arckens, Lutgarde]. PMID: 16455759 [PubMed - indexed for MEDLINE]Related articles

Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity.

Thupari JN, Pinn ML, Kuhajda FP.

Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23. Erratum in: Biochem Biophys Res Commun 2002 Jul 12;295(2):570. PMID: 11444828 [PubMed - indexed for MEDLINE]Related articles

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.

Pizer ES, Thupari J, Han WF, Pinn ML, Chrest FJ, Frehywot GL, Townsend CA, Kuhajda FP.

Cancer Res. 2000 Jan 15;60(2):213-8.PMID: 10667561 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha.

Cha SH, Rodgers JT, Puigserver P, Chohnan S, Lane MD.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15410-5. Epub 2006 Oct 9.PMID: 17030788 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic dopaminergic receptor expressions in anorexia of tumor-bearing rats.

Sato T, Meguid MM, Fetissov SO, Chen C, Zhang L.

Am J Physiol Regul Integr Comp Physiol. 2001 Dec;281(6):R1907-16.PMID: 11705777 [PubMed - indexed for MEDLINE]Related articles

Role of hypothalamic monoamines in nicotine-induced anorexia in menopausal rats.

Zhang L, Meguid MM, Miyata G, Varma M, Fetissov SO.

Surgery. 2001 Aug;130(2):133-42.PMID: 11490341 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intake.

López M, Lelliott CJ, Vidal-Puig A.

Bioessays. 2007 Mar;29(3):248-61. Review.PMID: 17295284 [PubMed - indexed for MEDLINE]Related articles

Regulation of hypothalamic malonyl-CoA by central glucose and leptin.

Wolfgang MJ, Cha SH, Sidhaye A, Chohnan S, Cline G, Shulman GI, Lane MD.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19285-90. Epub 2007 Nov 21.PMID: 18032600 [PubMed - indexed for MEDLINE]Related articlesFree article