PubMed

Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion.

Herrington J, Zhou YP, Bugianesi RM, Dulski PM, Feng Y, Warren VA, Smith MM, Kohler MG, Garsky VM, Sanchez M, Wagner M, Raphaelli K, Banerjee P, Ahaghotu C, Wunderler D, Priest BT, Mehl JT, Garcia ML, McManus OB, Kaczorowski GJ, Slaughter RS.

Diabetes. 2006 Apr;55(4):1034-42. Erratum in: Diabetes. 2006 Jun;55(6):1904. PMID: 16567526 [PubMed - indexed for MEDLINE]Related articlesFree article

Gating modifier peptides as probes of pancreatic beta-cell physiology.

Herrington J.

Toxicon. 2007 Feb;49(2):231-8. Epub 2006 Sep 23. Review.PMID: 17101164 [PubMed - indexed for MEDLINE]Related articles

Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling.

Tamarina NA, Kuznetsov A, Fridlyand LE, Philipson LH.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E578-85. Epub 2005 Jul 12.PMID: 16014354 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

MacDonald PE, Sewing S, Wang J, Joseph JW, Smukler SR, Sakellaropoulos G, Wang J, Saleh MC, Chan CB, Tsushima RG, Salapatek AM, Wheeler MB.

J Biol Chem. 2002 Nov 22;277(47):44938-45. Epub 2002 Sep 20.PMID: 12270920 [PubMed - indexed for MEDLINE]Related articlesFree article

Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion.

MacDonald PE, Ha XF, Wang J, Smukler SR, Sun AM, Gaisano HY, Salapatek AM, Backx PH, Wheeler MB.

Mol Endocrinol. 2001 Aug;15(8):1423-35.PMID: 11463864 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression and function of pancreatic beta-cell delayed rectifier K+ channels. Role in stimulus-secretion coupling.

Roe MW, Worley JF 3rd, Mittal AA, Kuznetsov A, DasGupta S, Mertz RJ, Witherspoon SM 3rd, Blair N, Lancaster ME, McIntyre MS, Shehee WR, Dukes ID, Philipson LH.

J Biol Chem. 1996 Dec 13;271(50):32241-6.PMID: 8943282 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis.

Kim SJ, Choi WS, Han JS, Warnock G, Fedida D, McIntosh CH.

J Biol Chem. 2005 Aug 5;280(31):28692-700. Epub 2005 Jun 13.PMID: 15955806 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological properties and functional role of Kslow current in mouse pancreatic beta-cells: SK channels contribute to Kslow tail current and modulate insulin secretion.

Zhang M, Houamed K, Kupershmidt S, Roden D, Satin LS.

J Gen Physiol. 2005 Oct;126(4):353-63.PMID: 16186562 [PubMed - indexed for MEDLINE]Related articlesFree article

SNAP-25(1-180) enhances insulin secretion by blocking Kv2.1 channels in rat pancreatic islet beta-cells.

Zhuang GQ, Wu W, Liu F, Ma JL, Luo YX, Xiao ZX, Liu Y, Wang W, He Y.

Biochem Biophys Res Commun. 2009 Feb 20;379(4):812-6. Epub 2008 Dec 25.PMID: 19103161 [PubMed - indexed for MEDLINE]Related articles

Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells.

Herrington J, Sanchez M, Wunderler D, Yan L, Bugianesi RM, Dick IE, Clark SA, Brochu RM, Priest BT, Kohler MG, McManus OB.

J Physiol. 2005 Aug 15;567(Pt 1):159-75. Epub 2005 Jun 2.PMID: 15932888 [PubMed - indexed for MEDLINE]Related articlesFree article

Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.

Braun M, Ramracheya R, Bengtsson M, Zhang Q, Karanauskaite J, Partridge C, Johnson PR, Rorsman P.

Diabetes. 2008 Jun;57(6):1618-28. Epub 2008 Apr 4.PMID: 18390794 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel enhancer of insulinotrophic action by high glucose (JTT-608) stimulates insulin secretion from pancreatic beta-cells via a new cellular mechanism.

Itabashi N, Okada K, Muto S, Fujita N, Ohta T, Miyazaki Ji, Asano Y, Saito T.

J Pharmacol Exp Ther. 2001 Jun;297(3):953-60.PMID: 11356916 [PubMed - indexed for MEDLINE]Related articlesFree article

Single-microelectrode voltage clamp measurements of pancreatic beta-cell membrane ionic currents in situ.

Rojas E, Stokes CL, Mears D, Atwater I.

J Membr Biol. 1995 Jan;143(1):65-77.PMID: 7714889 [PubMed - indexed for MEDLINE]Related articles

Perchlorate stimulates insulin secretion by shifting the gating of L-type Ca2+ currents in mouse pancreatic B-cells towards negative potentials.

Larsson-Nyrén G, Sehlin J, Rorsman P, Renström E.

Pflugers Arch. 2001 Feb;441(5):587-95.PMID: 11294239 [PubMed - indexed for MEDLINE]Related articles

Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets.

MacDonald PE, Wheeler MB.

Diabetologia. 2003 Aug;46(8):1046-62. Epub 2003 Jun 27. Review.PMID: 12830383 [PubMed - indexed for MEDLINE]Related articles

Delayed rectifier K+ channel overexpression in transgenic islets and beta-cells associated with impaired glucose responsiveness.

Philipson LH, Rosenberg MP, Kuznetsov A, Lancaster ME, Worley JF 3rd, Roe MW, Dukes ID.

J Biol Chem. 1994 Nov 11;269(45):27787-90.PMID: 7961701 [PubMed - indexed for MEDLINE]Related articlesFree article

Crosstalk between membrane potential and cytosolic Ca2+ concentration in beta cells from Sur1-/- mice.

Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G, Düfer M.

Diabetologia. 2005 May;48(5):913-21. Epub 2005 Apr 14.PMID: 15830184 [PubMed - indexed for MEDLINE]Related articles

Inositol trisphosphate-dependent periodic activation of a Ca(2+)-activated K+ conductance in glucose-stimulated pancreatic beta-cells.

Ammälä C, Larsson O, Berggren PO, Bokvist K, Juntti-Berggren L, Kindmark H, Rorsman P.

Nature. 1991 Oct 31;353(6347):849-52.PMID: 1719424 [PubMed - indexed for MEDLINE]Related articles

Insulin activates ATP-sensitive K(+) channels in pancreatic beta-cells through a phosphatidylinositol 3-kinase-dependent pathway.

Khan FA, Goforth PB, Zhang M, Satin LS.

Diabetes. 2001 Oct;50(10):2192-8.PMID: 11574397 [PubMed - indexed for MEDLINE]Related articlesFree article

Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release.

Misaki N, Mao X, Lin YF, Suga S, Li GH, Liu Q, Chang Y, Wang H, Wakui M, Wu J.

J Pharmacol Exp Ther. 2007 Aug;322(2):871-8. Epub 2007 May 23.PMID: 17522344 [PubMed - indexed for MEDLINE]Related articlesFree article