PubMed

Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus.

Lenert PS.

Arthritis Res Ther. 2006;8(1):203. Epub 2006 Jan 10. Review.PMID: 16542467 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Faslpr/lpr mice in vivo.

Lenert P, Yasuda K, Busconi L, Nelson P, Fleenor C, Ratnabalasuriar RS, Nagy PL, Ashman RF, Rifkin IR, Marshak-Rothstein A.

Arthritis Res Ther. 2009;11(3):R79. Epub 2009 May 28.PMID: 19476613 [PubMed - in process]Related articlesFree article

Expansion of toll-like receptor 9-expressing B cells in active systemic lupus erythematosus: implications for the induction and maintenance of the autoimmune process.

Papadimitraki ED, Choulaki C, Koutala E, Bertsias G, Tsatsanis C, Gergianaki I, Raptopoulou A, Kritikos HD, Mamalaki C, Sidiropoulos P, Boumpas DT.

Arthritis Rheum. 2006 Nov;54(11):3601-11.PMID: 17075805 [PubMed - indexed for MEDLINE]Related articlesFree article

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus.

Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL.

J Exp Med. 2005 Oct 17;202(8):1131-9.PMID: 16230478 [PubMed - indexed for MEDLINE]Related articlesFree article

Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice.

Brummel R, Roberts TL, Stacey KJ, Lenert P.

Eur J Immunol. 2006 Jul;36(7):1951-62.PMID: 16791898 [PubMed - indexed for MEDLINE]Related articles

Modifying toll-like receptor 9 signaling for therapeutic use.

Bhattacharjee RN, Akira S.

Mini Rev Med Chem. 2006 Mar;6(3):287-91.PMID: 16515467 [PubMed - indexed for MEDLINE]Related articles

Differential signaling by CpG DNA in DCs and B cells: not just TLR9.

Verthelyi D, Zeuner RA.

Trends Immunol. 2003 Oct;24(10):519-22. Review.PMID: 14552833 [PubMed - indexed for MEDLINE]Related articles

TLR9 as a key receptor for the recognition of DNA.

Kumagai Y, Takeuchi O, Akira S.

Adv Drug Deliv Rev. 2008 Apr 29;60(7):795-804. Epub 2008 Jan 3. Review.PMID: 18262306 [PubMed - indexed for MEDLINE]Related articles

TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production.

Lenert P, Brummel R, Field EH, Ashman RF.

J Clin Immunol. 2005 Jan;25(1):29-40.PMID: 15742155 [PubMed - indexed for MEDLINE]Related articles

CpG-DNA as immune response modifier.

Dalpke AH, Heeg K.

Int J Med Microbiol. 2004 Oct;294(5):345-54. Review.PMID: 15532993 [PubMed - indexed for MEDLINE]Related articles

Development of TLR inhibitors for the treatment of autoimmune diseases.

Barrat FJ, Coffman RL.

Immunol Rev. 2008 Jun;223:271-83. Review.PMID: 18613842 [PubMed - indexed for MEDLINE]Related articles

Signaling in B cells via Toll-like receptors.

Peng SL.

Curr Opin Immunol. 2005 Jun;17(3):230-6. Review.PMID: 15886111 [PubMed - indexed for MEDLINE]Related articles

Nucleic acid recognition receptors in autoimmunity.

Krug A.

Handb Exp Pharmacol. 2008;(183):129-51. Review.PMID: 18071658 [PubMed - indexed for MEDLINE]Related articles

Impact of class A, B and C CpG-oligodeoxynucleotides on in vitro activation of innate immune cells in human immunodeficiency virus-1 infected individuals.

Martinson JA, Tenorio AR, Montoya CJ, Al-Harthi L, Gichinga CN, Krieg AM, Baum LL, Landay AL.

Immunology. 2007 Apr;120(4):526-35.PMID: 17343615 [PubMed - indexed for MEDLINE]Related articlesFree article

Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF.

Xu W, Santini PA, Matthews AJ, Chiu A, Plebani A, He B, Chen K, Cerutti A.

J Immunol. 2008 Jul 1;181(1):276-87.PMID: 18566393 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of innate immune responses in autoimmune disease development.

Waldner H.

Autoimmun Rev. 2009 Mar;8(5):400-4. Epub 2009 Jan 20. Review.PMID: 19162250 [PubMed - indexed for MEDLINE]Related articles

Polyinosinic acid is a ligand for toll-like receptor 3.

Marshall-Clarke S, Downes JE, Haga IR, Bowie AG, Borrow P, Pennock JL, Grencis RK, Rothwell P.

J Biol Chem. 2007 Aug 24;282(34):24759-66. Epub 2007 Jun 14.PMID: 17573354 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity.

Peter M, Bode K, Lipford GB, Eberle F, Heeg K, Dalpke AH.

Immunology. 2008 Jan;123(1):118-28. Epub 2007 Oct 23.PMID: 17961163 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists.

Birmachu W, Gleason RM, Bulbulian BJ, Riter CL, Vasilakos JP, Lipson KE, Nikolsky Y.

BMC Immunol. 2007 Oct 12;8:26.PMID: 17935622 [PubMed - indexed for MEDLINE]Related articlesFree article

CpG-B ODNs potently induce low levels of IFN-alphabeta and induce IFN-alphabeta-dependent MHC-I cross-presentation in DCs as effectively as CpG-A and CpG-C ODNs.

Gray RC, Kuchtey J, Harding CV.

J Leukoc Biol. 2007 Apr;81(4):1075-85. Epub 2007 Jan 16.PMID: 17227820 [PubMed - indexed for MEDLINE]Related articlesFree article