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Enhanced mitogenic signaling in skeletal muscle of women with polycystic ovary syndrome.

Corbould A, Zhao H, Mirzoeva S, Aird F, Dunaif A.

Diabetes. 2006 Mar;55(3):751-9.PMID: 16505239 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling.

Corbould A, Kim YB, Youngren JF, Pender C, Kahn BB, Lee A, Dunaif A.

Am J Physiol Endocrinol Metab. 2005 May;288(5):E1047-54. Epub 2004 Dec 21.PMID: 15613682 [PubMed - indexed for MEDLINE]Related articlesFree article

The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome.

Corbould A, Dunaif A.

Metabolism. 2007 May;56(5):716-22.PMID: 17445549 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells.

Andreozzi F, Laratta E, Sciacqua A, Perticone F, Sesti G.

Circ Res. 2004 May 14;94(9):1211-8. Epub 2004 Mar 25.PMID: 15044323 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes.

Bouzakri K, Roques M, Gual P, Espinosa S, Guebre-Egziabher F, Riou JP, Laville M, Le Marchand-Brustel Y, Tanti JF, Vidal H.

Diabetes. 2003 Jun;52(6):1319-25.PMID: 12765939 [PubMed - indexed for MEDLINE]Related articlesFree article

Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS).

Dunaif A, Wu X, Lee A, Diamanti-Kandarakis E.

Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E392-9.PMID: 11440917 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome.

Nelson-Degrave VL, Wickenheisser JK, Hendricks KL, Asano T, Fujishiro M, Legro RS, Kimball SR, Strauss JF 3rd, McAllister JM.

Mol Endocrinol. 2005 Feb;19(2):379-90. Epub 2004 Oct 28.PMID: 15514033 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance in polycystic ovary syndrome: progress and paradoxes.

Venkatesan AM, Dunaif A, Corbould A.

Recent Prog Horm Res. 2001;56:295-308. Review.PMID: 11237218 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor-alpha induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway.

Li G, Barrett EJ, Barrett MO, Cao W, Liu Z.

Endocrinology. 2007 Jul;148(7):3356-63. Epub 2007 Apr 19.PMID: 17446186 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo.

Rajkhowa M, Brett S, Cuthbertson DJ, Lipina C, Ruiz-Alcaraz AJ, Thomas GE, Logie L, Petrie JR, Sutherland C.

Biochem J. 2009 Mar 15;418(3):665-71.PMID: 19053948 [PubMed - indexed for MEDLINE]Related articles

Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes.

Hers I, Tavaré JM.

Biochem J. 2005 Jun 1;388(Pt 2):713-20.PMID: 15713122 [PubMed - indexed for MEDLINE]Related articlesFree article

Amelioration of insulin resistance in women with PCOS via reduced insulin receptor substrate-1 Ser312 phosphorylation following laparoscopic ovarian electrocautery.

Seow KM, Juan CC, Hsu YP, Hwang JL, Huang LW, Ho LT.

Hum Reprod. 2007 Apr;22(4):1003-10. Epub 2007 Jan 4.PMID: 17204522 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective ovary resistance to insulin signaling in women with polycystic ovary syndrome.

Wu XK, Zhou SY, Liu JX, Pöllänen P, Sallinen K, Mäkinen M, Erkkola R.

Fertil Steril. 2003 Oct;80(4):954-65.PMID: 14556818 [PubMed - indexed for MEDLINE]Related articles

Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.

Huang C, Thirone AC, Huang X, Klip A.

J Biol Chem. 2005 May 13;280(19):19426-35. Epub 2005 Mar 11.PMID: 15764603 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective insulin resistance in the polycystic ovary syndrome.

Book CB, Dunaif A.

J Clin Endocrinol Metab. 1999 Sep;84(9):3110-6.PMID: 10487672 [PubMed - indexed for MEDLINE]Related articlesFree article

Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.

Dunaif A, Xia J, Book CB, Schenker E, Tang Z.

J Clin Invest. 1995 Aug;96(2):801-10.PMID: 7635975 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation.

Zhang Q, Carter EA, Ma BY, White M, Fischman AJ, Tompkins RG.

Life Sci. 2005 Oct 28;77(24):3068-77. Epub 2005 Jun 27.PMID: 15982669 [PubMed - indexed for MEDLINE]Related articles

Chronic exposure to ketone bodies impairs glucose uptake in adult cardiomyocytes in response to insulin but not vanadate: the role of PI3-K.

Pelletier A, Tardif A, Gingras MH, Chiasson JL, Coderre L.

Mol Cell Biochem. 2007 Feb;296(1-2):97-108. Epub 2006 Sep 8.PMID: 16960657 [PubMed - indexed for MEDLINE]Related articles

Peroxynitrite activates ERK via Raf-1 and MEK, independently from EGF receptor and p21Ras in H9C2 cardiomyocytes.

Pesse B, Levrand S, Feihl F, Waeber B, Gavillet B, Pacher P, Liaudet L.

J Mol Cell Cardiol. 2005 May;38(5):765-75.PMID: 15850570 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced insulin action on glucose transport and insulin signaling in 7-day unweighted rat soleus muscle.

O'Keefe MP, Perez FR, Sloniger JA, Tischler ME, Henriksen EJ.

J Appl Physiol. 2004 Jul;97(1):63-71. Epub 2004 Mar 5.PMID: 15004002 [PubMed - indexed for MEDLINE]Related articlesFree article