PubMed

Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance.

Kim YW, Kim JY, Park YH, Park SY, Won KC, Choi KH, Huh JY, Moon KH.

Diabetes. 2006 Mar;55(3):716-24.PMID: 16505235 [PubMed - indexed for MEDLINE]Related articlesFree article

Established maternal obesity in the rat reprograms hypothalamic appetite regulators and leptin signaling at birth.

Morris MJ, Chen H.

Int J Obes (Lond). 2009 Jan;33(1):115-22. Epub 2008 Nov 4.PMID: 18982008 [PubMed - indexed for MEDLINE]Related articles

Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity.

Wilsey J, Zolotukhin S, Prima V, Scarpace PJ.

Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R1011-20.PMID: 14557234 [PubMed - indexed for MEDLINE]Related articles

[Effects of rosiglitazone and metformin on insulin resistance in high-fat diet rats]

Chen XP, Yang WY, Bu S, Xiao JZ, Liu XL, Wang N, Zhao WH.

Zhonghua Nei Ke Za Zhi. 2004 Apr;43(4):280-3. Chinese. PMID: 15130413 [PubMed - indexed for MEDLINE]Related articles

Effects of PPARgamma and PPARalpha agonists on serum leptin levels in diet-induced obese rats.

Törüner F, Akbay E, Cakir N, Sancak B, Elbeg S, Taneri F, Aktürk M, Karakoç A, Ayvaz G, Arslan M.

Horm Metab Res. 2004 Apr;36(4):226-30.PMID: 15114521 [PubMed - indexed for MEDLINE]Related articles

Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle.

Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB.

J Biol Chem. 2006 Jul 14;281(28):18933-41. Epub 2006 May 10.PMID: 16687413 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel black soy peptides with antiobesity effects: activation of leptin-like signaling and AMP-activated protein kinase.

Jang EH, Moon JS, Ko JH, Ahn CW, Lee HH, Shin JK, Park CS, Kang JH.

Int J Obes (Lond). 2008 Jul;32(7):1161-70. Epub 2008 Apr 15.PMID: 18414417 [PubMed - indexed for MEDLINE]Related articles

Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice.

Steinberg GR, Watt MJ, Fam BC, Proietto J, Andrikopoulos S, Allen AM, Febbraio MA, Kemp BE.

Endocrinology. 2006 Aug;147(8):3906-14. Epub 2006 May 4.PMID: 16675525 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-obesity effects of Juniperus chinensis extract are associated with increased AMP-activated protein kinase expression and phosphorylation in the visceral adipose tissue of rats.

Kim SJ, Jung JY, Kim HW, Park T.

Biol Pharm Bull. 2008 Jul;31(7):1415-21.PMID: 18591785 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-sensitizing action of rosiglitazone is enhanced by preventing hyperphagia.

Pickavance LC, Buckingham RE, Wilding JP.

Diabetes Obes Metab. 2001 Jun;3(3):171-80.PMID: 11412281 [PubMed - indexed for MEDLINE]Related articles

Metformin restores the penile expression of nitric oxide synthase in high-fat-fed obese rats.

Kim YW, Park SY, Kim JY, Huh JY, Jeon WS, Yoon CJ, Yun SS, Moon KH.

J Androl. 2007 Jul-Aug;28(4):555-60. Epub 2007 Feb 21.PMID: 17314235 [PubMed - indexed for MEDLINE]Related articlesFree article

Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men.

Fruehwald-Schultes B, Oltmanns KM, Toschek B, Sopke S, Kern W, Born J, Fehm HL, Peters A.

Metabolism. 2002 Apr;51(4):531-6.PMID: 11912566 [PubMed - indexed for MEDLINE]Related articles

Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant rats.

Shapiro A, Matheny M, Zhang Y, Tümer N, Cheng KY, Rogrigues E, Zolotukhin S, Scarpace PJ.

Diabetes. 2008 Mar;57(3):614-22. Epub 2007 Dec 17.PMID: 18086903 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin restores responses to insulin but not to growth hormone in Sprague-Dawley rats.

Borst SE, Snellen HG, Ross H, Scarpace PJ, Kim YW.

Biochem Biophys Res Commun. 2002 Mar 1;291(3):722-6.PMID: 11855850 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats.

Ye JM, Dzamko N, Hoy AJ, Iglesias MA, Kemp B, Kraegen E.

Diabetes. 2006 Oct;55(10):2797-804.PMID: 17003345 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of diet and time of the day on serum and CSF leptin levels in Osborne-Mendel and S5B/Pl rats.

Ishihara Y, White CL, Kageyama H, Kageyama A, York DA, Bray GA.

Obes Res. 2004 Jul;12(7):1067-76.PMID: 15292470 [PubMed - indexed for MEDLINE]Related articles

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity.

El-Haschimi K, Pierroz DD, Hileman SM, Bjørbaek C, Flier JS.

J Clin Invest. 2000 Jun;105(12):1827-32.PMID: 10862798 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension.

Tümer N, Erdös B, Matheny M, Cudykier I, Scarpace PJ.

J Hypertens. 2007 Dec;25(12):2471-8.PMID: 17984669 [PubMed - indexed for MEDLINE]Related articles

Long-term effects of central leptin and resistin on body weight, insulin resistance, and beta-cell function and mass by the modulation of hypothalamic leptin and insulin signaling.

Park S, Hong SM, Sung SR, Jung HK.

Endocrinology. 2008 Feb;149(2):445-54. Epub 2007 Nov 8.PMID: 17991727 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent.

Zhang J, Matheny MK, Tümer N, Mitchell MK, Scarpace PJ.

Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R868-74. Epub 2006 Oct 5.PMID: 17023670 [PubMed - indexed for MEDLINE]Related articles