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    Results: 1 to 20 of 363

    1.

    Dynamics of glucose-induced localization of PKC isoenzymes in pancreatic beta-cells: diabetes-related changes in the GK rat.

    Warwar N, Efendic S, Ostenson CG, Haber EP, Cerasi E, Nesher R.

    Diabetes. 2006 Mar;55(3):590-9.PMID: 16505220 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki rats.

    Rose T, Efendic S, Rupnik M.

    J Gen Physiol. 2007 Jun;129(6):493-508.PMID: 17535961 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Beta-cell protein kinases and the dynamics of the insulin response to glucose.

    Nesher R, Anteby E, Yedovizky M, Warwar N, Kaiser N, Cerasi E.

    Diabetes. 2002 Feb;51 Suppl 1:S68-73. Review.PMID: 11815461 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP production.

    Dolz M, Bailbé D, Giroix MH, Calderari S, Gangnerau MN, Serradas P, Rickenbach K, Irminger JC, Portha B.

    Diabetes. 2005 Nov;54(11):3229-37.PMID: 16249449 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats: a defect ameliorated by cAMP.

    Abdel-Halim SM, Guenifi A, Khan A, Larsson O, Berggren PO, Ostenson CG, Efendić S.

    Diabetes. 1996 Jul;45(7):934-40.PMID: 8666145 [PubMed - indexed for MEDLINE]Related articles

    6.

    Signal transduction in pancreatic beta-cells: regulation of insulin secretion by information flow in the phospholipase C/protein kinase C pathway.

    Zawalich WS, Bonnet-Eymard M, Zawalich KC.

    Front Biosci. 1997 Mar 15;2:d160-72. Review.PMID: 9159224 [PubMed - indexed for MEDLINE]Related articles

    7.

    Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat.

    Movassat J, Saulnier C, Serradas P, Portha B.

    Diabetologia. 1997 Aug;40(8):916-25.PMID: 9267986 [PubMed - indexed for MEDLINE]Related articles

    8.

    Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose.

    Dov A, Abramovitch E, Warwar N, Nesher R.

    Endocrinology. 2008 Feb;149(2):741-8. Epub 2007 Nov 8.PMID: 17991719 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Overexpression of mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase does not correct glucose-stimulated insulin secretion from diabetic GK rat pancreatic islets.

    Ueda K, Tanizawa Y, Ishihara H, Kizuki N, Ohta Y, Matsutani A, Oka Y.

    Diabetologia. 1998 Jun;41(6):649-53.PMID: 9662045 [PubMed - indexed for MEDLINE]Related articles

    10.

    Is defective pancreatic beta-cell mass environmentally programmed in Goto-Kakizaki rat model of type 2 diabetes?: insights from crossbreeding studies during suckling period.

    Calderari S, Gangnerau MN, Meile MJ, Portha B, Serradas P.

    Pancreas. 2006 Nov;33(4):412-7.PMID: 17079948 [PubMed - indexed for MEDLINE]Related articles

    11.

    Beta-cell mass depletion precedes the onset of hyperglycaemia in the GK rat, a genetic model of non-insulin-dependent diabetes mellitus.

    Movassat J, Saulnier C, Portha B.

    Diabete Metab. 1995 Dec;21(5):365-70.PMID: 8586154 [PubMed - indexed for MEDLINE]Related articles

    12.

    Inhibition of protein-tyrosine phosphatases stimulates insulin secretion in pancreatic islets of diabetic Goto-Kakizaki rats.

    Chen J, Ostenson CG.

    Pancreas. 2005 May;30(4):314-7.PMID: 15841039 [PubMed - indexed for MEDLINE]Related articles

    13.

    Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetics GK rats and its defective augmentation by glucose.

    Okamoto Y, Ishida H, Tsuura Y, Yasuda K, Kato S, Matsubara H, Nishimura M, Mizuno N, Ikeda H, Seino Y.

    Diabetologia. 1995 Jul;38(7):772-8.PMID: 7556977 [PubMed - indexed for MEDLINE]Related articles

    14.

    TIRF imaging of docking and fusion of single insulin granule motion in primary rat pancreatic beta-cells: different behaviour of granule motion between normal and Goto-Kakizaki diabetic rat beta-cells.

    Ohara-Imaizumi M, Nishiwaki C, Kikuta T, Nagai S, Nakamichi Y, Nagamatsu S.

    Biochem J. 2004 Jul 1;381(Pt 1):13-8.PMID: 15128287 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes.

    Portha B, Serradas P, Bailbé D, Suzuki K, Goto Y, Giroix MH.

    Diabetes. 1991 Apr;40(4):486-91.PMID: 2010050 [PubMed - indexed for MEDLINE]Related articles

    16.

    Alteration of beta-cell constitutive NO synthase activity is involved in the abnormal insulin response to arginine in a new rat model of type 2 diabetes.

    Novelli M, Pocai A, Lajoix AD, Beffy P, Bezzi D, Marchetti P, Gross R, Masiello P.

    Mol Cell Endocrinol. 2004 Apr 30;219(1-2):77-82.PMID: 15149729 [PubMed - indexed for MEDLINE]Related articles

    17.

    Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells.

    Suzuki Y, Zhang H, Saito N, Kojima I, Urano T, Mogami H.

    J Biol Chem. 2006 Sep 29;281(39):28499-507. Epub 2006 Jul 26.PMID: 16870611 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells.

    Uchida T, Iwashita N, Ohara-Imaizumi M, Ogihara T, Nagai S, Choi JB, Tamura Y, Tada N, Kawamori R, Nakayama KI, Nagamatsu S, Watada H.

    J Biol Chem. 2007 Jan 26;282(4):2707-16. Epub 2006 Nov 29.PMID: 17135234 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes.

    Calderari S, Gangnerau MN, Thibault M, Meile MJ, Kassis N, Alvarez C, Portha B, Serradas P.

    Diabetologia. 2007 Jul;50(7):1463-71. Epub 2007 May 3.PMID: 17476475 [PubMed - indexed for MEDLINE]Related articles

    20.

    Characterization of the action of S 21403 (mitiglinide) on insulin secretion and biosynthesis in normal and diabetic beta-cells.

    Kaiser N, Nesher R, Oprescu A, Efendic S, Cerasi E.

    Br J Pharmacol. 2005 Nov;146(6):872-81.PMID: 16158072 [PubMed - indexed for MEDLINE]Related articlesFree article

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