PubMed

The induction of CCN2 by TGFbeta1 involves Ets-1.

Van Beek JP, Kennedy L, Rockel JS, Bernier SM, Leask A.

Arthritis Res Ther. 2006;8(2):R36. Epub 2006 Jan 16.PMID: 16469114 [PubMed - indexed for MEDLINE]Related articlesFree article

Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program.

Nakerakanti SS, Kapanadze B, Yamasaki M, Markiewicz M, Trojanowska M.

J Biol Chem. 2006 Sep 1;281(35):25259-69. Epub 2006 Jul 6.PMID: 16829517 [PubMed - indexed for MEDLINE]Related articlesFree article

Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells.

Gao R, Ball DK, Perbal B, Brigstock DR.

J Hepatol. 2004 Mar;40(3):431-8.PMID: 15123357 [PubMed - indexed for MEDLINE]Related articles

CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.

Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A.

J Biol Chem. 2006 Apr 21;281(16):10715-26. Epub 2006 Feb 16.PMID: 16484225 [PubMed - indexed for MEDLINE]Related articlesFree article

The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells.

Phanish MK, Wahab NA, Colville-Nash P, Hendry BM, Dockrell ME.

Biochem J. 2006 Jan 15;393(Pt 2):601-7.PMID: 16253118 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular requirements for induction of CTGF expression by TGF-beta1 in primary osteoblasts.

Arnott JA, Zhang X, Sanjay A, Owen TA, Smock SL, Rehman S, DeLong WG, Safadi FF, Popoff SN.

Bone. 2008 May;42(5):871-85. Epub 2008 Jan 26.PMID: 18314002 [PubMed - indexed for MEDLINE]Related articlesFree article

Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts.

Leask A, Holmes A, Black CM, Abraham DJ.

J Biol Chem. 2003 Apr 11;278(15):13008-15. Epub 2003 Feb 5.PMID: 12571253 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase.

Black SA Jr, Palamakumbura AH, Stan M, Trackman PC.

J Biol Chem. 2007 May 25;282(21):15416-29. Epub 2007 Apr 10.PMID: 17428796 [PubMed - indexed for MEDLINE]Related articlesFree article

Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness.

Mori Y, Hinchcliff M, Wu M, Warner-Blankenship M, M Lyons K, Varga J.

Exp Cell Res. 2008 Mar 10;314(5):1094-104. Epub 2007 Dec 23.PMID: 18201696 [PubMed - indexed for MEDLINE]Related articles

Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression.

Black SA Jr, Trackman PC.

J Biol Chem. 2008 Apr 18;283(16):10835-47. Epub 2008 Feb 20.PMID: 18287089 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of connective tissue growth factor in pancreatic cancer cell lines.

Kwon S, Munroe X, Crawley SC, Lee HY, Spong S, Bradham D, Gum JR Jr, Sleisenger MH, Kim YS.

Int J Oncol. 2007 Oct;31(4):693-703.PMID: 17786299 [PubMed - indexed for MEDLINE]Related articles

Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines.

Eguchi T, Kubota S, Kawata K, Mukudai Y, Ohgawara T, Miyazono K, Nakao K, Kondo S, Takigawa M.

Biochimie. 2007 Mar;89(3):278-88. Epub 2007 Jan 3.PMID: 17291666 [PubMed - indexed for MEDLINE]Related articles

The expression of novH in adrenocortical cells is down-regulated by TGFbeta 1 through c-Jun in a Smad-independent manner.

Lafont J, Laurent M, Thibout H, Lallemand F, Le Bouc Y, Atfi A, Martinerie C.

J Biol Chem. 2002 Oct 25;277(43):41220-9. Epub 2002 Jul 30.PMID: 12149257 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.

Pannu J, Nakerakanti S, Smith E, ten Dijke P, Trojanowska M.

J Biol Chem. 2007 Apr 6;282(14):10405-13. Epub 2007 Feb 15.PMID: 17317656 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamic analysis of the expression of the TGFbeta/SMAD2 pathway and CCN2/CTGF during early steps of tooth development.

Pacheco MS, Reis AH, Aguiar DP, Lyons KM, Abreu JG.

Cells Tissues Organs. 2008;187(3):199-210. Epub 2007 Dec 17.PMID: 18089935 [PubMed - indexed for MEDLINE]Related articlesFree article

The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts.

Leask A, Sa S, Holmes A, Shiwen X, Black CM, Abraham DJ.

Mol Pathol. 2001 Jun;54(3):180-3.PMID: 11376132 [PubMed - indexed for MEDLINE]Related articlesFree article

CCNs, fibulin-1C and S100A4 expression in leiomyoma and myometrium: inverse association with TGF-beta and regulation by TGF-beta in leiomyoma and myometrial smooth muscle cells.

Luo X, Ding L, Chegini N.

Mol Hum Reprod. 2006 Apr;12(4):245-56. Epub 2006 Mar 29.PMID: 16571622 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of the TGFbeta/Smad signaling pathway in mesangial cells by CTGF/CCN2.

Wahab NA, Weston BS, Mason RM.

Exp Cell Res. 2005 Jul 15;307(2):305-14. Epub 2005 Apr 22.PMID: 15950619 [PubMed - indexed for MEDLINE]Related articles

Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: a role for CCN2 and low concentration of TGF-beta1.

Haydont V, Riser BL, Aigueperse J, Vozenin-Brotons MC.

Am J Physiol Cell Physiol. 2008 Jun;294(6):C1332-41. Epub 2008 Apr 9.PMID: 18400984 [PubMed - indexed for MEDLINE]Related articlesFree article

Poly(ADP-ribose) polymerase-1 enhances transcription of the profibrotic CCN2 gene.

Okada H, Inoue T, Kikuta T, Kato N, Kanno Y, Hirosawa N, Sakamoto Y, Sugaya T, Suzuki H.

J Am Soc Nephrol. 2008 May;19(5):933-42. Epub 2008 Feb 20.PMID: 18287562 [PubMed - indexed for MEDLINE]Related articlesFree article