PubMed

D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells.

Ryabinina OP, Subbian E, Iordanov MS.

BMC Cell Biol. 2006 Feb 1;7:7.PMID: 16451733 [PubMed - indexed for MEDLINE]Related articlesFree article

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation.

Luo W, Ng WW, Jin LH, Ye Z, Han J, Lin SC.

J Biol Chem. 2003 Sep 26;278(39):37451-8. Epub 2003 Jul 23.PMID: 12878610 [PubMed - indexed for MEDLINE]Related articlesFree article

Signal transduction pathways regulated by arsenate and arsenite.

Porter AC, Fanger GR, Vaillancourt RR.

Oncogene. 1999 Dec 16;18(54):7794-802.PMID: 10618720 [PubMed - indexed for MEDLINE]Related articlesFree article

A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK.

Inoue H, Tateno M, Fujimura-Kamada K, Takaesu G, Adachi-Yamada T, Ninomiya-Tsuji J, Irie K, Nishida Y, Matsumoto K.

EMBO J. 2001 Oct 1;20(19):5421-30.PMID: 11574474 [PubMed - indexed for MEDLINE]Related articlesFree article

MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.

Holland PM, Suzanne M, Campbell JS, Noselli S, Cooper JA.

J Biol Chem. 1997 Oct 3;272(40):24994-8.PMID: 9312105 [PubMed - indexed for MEDLINE]Related articlesFree article

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.

Takekawa M, Saito H.

Cell. 1998 Nov 13;95(4):521-30.PMID: 9827804 [PubMed - indexed for MEDLINE]Related articles

MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.

Abell AN, Granger DA, Johnson GL.

J Biol Chem. 2007 Oct 19;282(42):30476-84. Epub 2007 Aug 28.PMID: 17726008 [PubMed - indexed for MEDLINE]Related articlesFree article

Requirement of MKK4 and MKK7 for CdCl2- or HgCl2-induced activation of c-Jun NH2-terminal kinase in mouse embryonic stem cells.

Matsuoka M, Igisu H, Nakagawa K, Katada T, Nishina H.

Toxicol Lett. 2004 Sep 10;152(2):175-81.PMID: 15302099 [PubMed - indexed for MEDLINE]Related articles

The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.

Wong CK, Luo W, Deng Y, Zou H, Ye Z, Lin SC.

J Biol Chem. 2004 Sep 17;279(38):39366-73. Epub 2004 Jul 15.PMID: 15262978 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation mechanism and physiological roles of stress-activated protein kinase/c-Jun NH2-terminal kinase in mammalian cells.

Nishina H, Nakagawa K, Azuma N, Katada T.

J Biol Regul Homeost Agents. 2003 Oct-Dec;17(4):295-302. Review.PMID: 15065757 [PubMed - indexed for MEDLINE]Related articles

Arsenite induces apoptosis in hepatocytes through an enhancement of the activation of Jun N-terminal kinase and p38 mitogen-activated protein kinase caused by partial hepatectomy.

Suzuki T, Tsukamoto I.

Toxicol Lett. 2006 Sep 10;165(3):257-64. Epub 2006 May 12.PMID: 16797887 [PubMed - indexed for MEDLINE]Related articles

Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases.

Ho DT, Bardwell AJ, Grewal S, Iverson C, Bardwell L.

J Biol Chem. 2006 May 12;281(19):13169-79. Epub 2006 Mar 13.PMID: 16533805 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the Drosophila melanogaster GADD45 homolog (CG11086) affects egg asymmetric development that is mediated by the c-Jun N-terminal kinase pathway.

Peretz G, Bakhrat A, Abdu U.

Genetics. 2007 Nov;177(3):1691-702.PMID: 18039880 [PubMed - indexed for MEDLINE]Related articlesFree article

p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription.

Cai B, Xia Z.

Apoptosis. 2008 Jun;13(6):803-10.PMID: 18465250 [PubMed - indexed for MEDLINE]Related articlesFree article

Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase.

Abell AN, Granger DA, Johnson NL, Vincent-Jordan N, Dibble CF, Johnson GL.

Mol Cell Biol. 2009 May;29(10):2748-61. Epub 2009 Mar 16.PMID: 19289495 [PubMed - indexed for MEDLINE]Related articlesFree article

JNK/c-Jun signaling mediates an anti-apoptotic effect of RANKL in osteoclasts.

Ikeda F, Matsubara T, Tsurukai T, Hata K, Nishimura R, Yoneda T.

J Bone Miner Res. 2008 Jun;23(6):907-14.PMID: 18251700 [PubMed - indexed for MEDLINE]Related articles

EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis.

Nuntharatanapong N, Chen K, Sinhaseni P, Keaney JF Jr.

Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H99-H107. Epub 2005 Feb 25.PMID: 15734884 [PubMed - indexed for MEDLINE]Related articlesFree article

The Drosophila cell shape regulator c-Jun N-terminal kinase also functions as a stress-activated protein kinase.

Botella JA, Baines IA, Williams DD, Goberdhan DC, Proud CG, Wilson C.

Insect Biochem Mol Biol. 2001 Jul 26;31(9):839-47.PMID: 11439243 [PubMed - indexed for MEDLINE]Related articles

Docetaxel-induced apoptosis of human melanoma is mediated by activation of c-Jun NH2-terminal kinase and inhibited by the mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway.

Mhaidat NM, Zhang XD, Jiang CC, Hersey P.

Clin Cancer Res. 2007 Feb 15;13(4):1308-14.PMID: 17317842 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domain.

Miyake Z, Takekawa M, Ge Q, Saito H.

Mol Cell Biol. 2007 Apr;27(7):2765-76. Epub 2007 Jan 22.PMID: 17242196 [PubMed - indexed for MEDLINE]Related articlesFree article