PubMed

Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1.

Lundholm M, Motta V, Löfgren-Burström A, Duarte N, Bergman ML, Mayans S, Holmberg D.

Diabetes. 2006 Feb;55(2):538-44.PMID: 16443792 [PubMed - indexed for MEDLINE]Related articlesFree article

The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis.

Greve B, Vijayakrishnan L, Kubal A, Sobel RA, Peterson LB, Wicker LS, Kuchroo VK.

J Immunol. 2004 Jul 1;173(1):157-63.PMID: 15210770 [PubMed - indexed for MEDLINE]Related articlesFree article

Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping.

Lyons PA, Armitage N, Argentina F, Denny P, Hill NJ, Lord CJ, Wilusz MB, Peterson LB, Wicker LS, Todd JA.

Genome Res. 2000 Apr;10(4):446-53.PMID: 10779485 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice.

Sgouroudis E, Albanese A, Piccirillo CA.

J Immunol. 2008 Nov 1;181(9):6283-92.PMID: 18941219 [PubMed - indexed for MEDLINE]Related articlesFree article

Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathy.

Brayer J, Lowry J, Cha S, Robinson CP, Yamachika S, Peck AB, Humphreys-Beher MG.

J Rheumatol. 2000 Aug;27(8):1896-904.PMID: 10955330 [PubMed - indexed for MEDLINE]Related articles

Genome-wide microarray expression analysis of CD4+ T Cells from nonobese diabetic congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type 1 diabetes.

Irie J, Reck B, Wu Y, Wicker LS, Howlett S, Rainbow D, Feingold E, Ridgway WM.

J Immunol. 2008 Jan 15;180(2):1071-9.PMID: 18178847 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

Araki M, Chung D, Liu S, Rainbow DB, Chamberlain G, Garner V, Hunter KM, Vijayakrishnan L, Peterson LB, Oukka M, Sharpe AH, Sobel R, Kuchroo VK, Wicker LS.

J Immunol. 2009 Oct 15;183(8):5146-57. Epub 2009 Sep 25.PMID: 19783679 [PubMed - indexed for MEDLINE]Related articles

Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse.

Kamanaka M, Rainbow D, Schuster-Gossler K, Eynon EE, Chervonsky AV, Wicker LS, Flavell RA.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11236-40. Epub 2009 Jun 22.PMID: 19549859 [PubMed - indexed for MEDLINE]Related articlesFree article

Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.

Wicker LS, Chamberlain G, Hunter K, Rainbow D, Howlett S, Tiffen P, Clark J, Gonzalez-Munoz A, Cumiskey AM, Rosa RL, Howson JM, Smink LJ, Kingsnorth A, Lyons PA, Gregory S, Rogers J, Todd JA, Peterson LB.

J Immunol. 2004 Jul 1;173(1):164-73.PMID: 15210771 [PubMed - indexed for MEDLINE]Related articlesFree article

Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice.

Lamhamedi-Cherradi SE, Boulard O, Gonzalez C, Kassis N, Damotte D, Eloy L, Fluteau G, Lévi-Strauss M, Garchon HJ.

Diabetes. 2001 Dec;50(12):2874-8.PMID: 11723074 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic dissection of type 1 diabetes susceptibility gene, Idd3, by ancestral haplotype congenic mapping.

Ikegami H, Fujisawa T, Makino S, Ogihara T.

Ann N Y Acad Sci. 2002 Apr;958:325-8.PMID: 12021134 [PubMed - indexed for MEDLINE]Related articles

SNPs upstream of the minimal promoter control IL-2 expression and are candidates for the autoimmune disease-susceptibility locus Aod2/Idd3/Eae3.

del Rio R, Noubade R, Subramanian M, Saligrama N, Diehl S, Rincon M, Teuscher C.

Genes Immun. 2008 Mar;9(2):115-21. Epub 2008 Jan 17.PMID: 18200031 [PubMed - indexed for MEDLINE]Related articles

Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background.

Cha S, Nagashima H, Brown VB, Peck AB, Humphreys-Beher MG.

Arthritis Rheum. 2002 May;46(5):1390-8.PMID: 12115247 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes.

Hunter K, Rainbow D, Plagnol V, Todd JA, Peterson LB, Wicker LS.

J Immunol. 2007 Dec 15;179(12):8341-9.PMID: 18056379 [PubMed - indexed for MEDLINE]Related articlesFree article

Cuttine edge: diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice.

Simpson PB, Mistry MS, Maki RA, Yang W, Schwarz DA, Johnson EB, Lio FM, Alleva DG.

J Immunol. 2003 Oct 1;171(7):3333-7.PMID: 14500624 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice.

Hamilton-Williams EE, Martinez X, Clark J, Howlett S, Hunter KM, Rainbow DB, Wen L, Shlomchik MJ, Katz JD, Beilhack GF, Wicker LS, Sherman LA.

J Immunol. 2009 Aug 1;183(3):1533-41. Epub 2009 Jul 10.PMID: 19592648 [PubMed - indexed for MEDLINE]Related articles

The NOD allele of the Idd5 locus on chromosome 1 mediates a non-cell-autonomous defect in negative selection of T cells.

Motta V, Lejon K, Holmberg D.

J Autoimmun. 2007 Jun;28(4):216-23. Epub 2007 Apr 20.PMID: 17449224 [PubMed - indexed for MEDLINE]Related articles

Analysis of the CTLA-4, CD28, and inducible costimulator (ICOS) genes in autoimmune thyroid disease.

Ban Y, Davies TF, Greenberg DA, Kissin A, Marder B, Murphy B, Concepcion ES, Villanueva RB, Barbesino G, Ling V, Tomer Y.

Genes Immun. 2003 Dec;4(8):586-93.PMID: 14647199 [PubMed - indexed for MEDLINE]Related articles

Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region.

Colucci F, Bergman ML, Penha-Gonçalves C, Cilio CM, Holmberg D.

Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8670-4.PMID: 9238035 [PubMed - indexed for MEDLINE]Related articlesFree article

A 20-Mb region of chromosome 4 controls TNF-alpha-mediated CD8+ T cell aggression toward beta cells in type 1 diabetes.

Chamberlain G, Wållberg M, Rainbow D, Hunter K, Wicker LS, Green EA.

J Immunol. 2006 Oct 15;177(8):5105-14.PMID: 17015694 [PubMed - indexed for MEDLINE]Related articlesFree article