PubMed

Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase.

Davis BJ, Xie Z, Viollet B, Zou MH.

Diabetes. 2006 Feb;55(2):496-505.PMID: 16443786 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species.

Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WG 4th, Schlattner U, Neumann D, Brownlee M, Freeman MB, Goldman MH.

J Biol Chem. 2004 Oct 15;279(42):43940-51. Epub 2004 Jul 19.PMID: 15265871 [PubMed - indexed for MEDLINE]Related articlesFree article

Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase.

Schulz E, Anter E, Zou MH, Keaney JF Jr.

Circulation. 2005 Jun 28;111(25):3473-80. Epub 2005 Jun 20.PMID: 15967841 [PubMed - indexed for MEDLINE]Related articlesFree article

Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway.

Levine YC, Li GK, Michel T.

J Biol Chem. 2007 Jul 13;282(28):20351-64. Epub 2007 May 22.PMID: 17519230 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase.

Zou MH, Hou XY, Shi CM, Nagata D, Walsh K, Cohen RA.

J Biol Chem. 2002 Sep 6;277(36):32552-7. Epub 2002 Jul 9.PMID: 12107173 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin stimulates production of nitric oxide in vascular endothelial cells.

Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ.

J Biol Chem. 2003 Nov 7;278(45):45021-6. Epub 2003 Aug 27.PMID: 12944390 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets.

Fleming I, Schulz C, Fichtlscherer B, Kemp BE, Fisslthaler B, Busse R.

Thromb Haemost. 2003 Nov;90(5):863-71.PMID: 14597982 [PubMed - indexed for MEDLINE]Related articles

Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells.

Morrow VA, Foufelle F, Connell JM, Petrie JR, Gould GW, Salt IP.

J Biol Chem. 2003 Aug 22;278(34):31629-39. Epub 2003 Jun 4.PMID: 12791703 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.

Xie Z, Dong Y, Scholz R, Neumann D, Zou MH.

Circulation. 2008 Feb 19;117(7):952-62. Epub 2008 Feb 4.PMID: 18250273 [PubMed - indexed for MEDLINE]Related articlesFree article

Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complex.

Takahashi S, Mendelsohn ME.

J Biol Chem. 2003 Aug 15;278(33):30821-7. Epub 2003 Jun 10.PMID: 12799359 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

Xie Z, Dong Y, Zhang M, Cui MZ, Cohen RA, Riek U, Neumann D, Schlattner U, Zou MH.

J Biol Chem. 2006 Mar 10;281(10):6366-75. Epub 2006 Jan 9.PMID: 16407220 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells.

Fleming I, Fisslthaler B, Dixit M, Busse R.

J Cell Sci. 2005 Sep 15;118(Pt 18):4103-11. Epub 2005 Aug 23.PMID: 16118242 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells.

Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA.

J Biol Chem. 2004 Nov 12;279(46):47898-905. Epub 2004 Sep 14.PMID: 15371448 [PubMed - indexed for MEDLINE]Related articlesFree article

Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells.

Brouet A, Sonveaux P, Dessy C, Balligand JL, Feron O.

J Biol Chem. 2001 Aug 31;276(35):32663-9. Epub 2001 Jun 25.PMID: 11425855 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor-alpha induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway.

Li G, Barrett EJ, Barrett MO, Cao W, Liu Z.

Endocrinology. 2007 Jul;148(7):3356-63. Epub 2007 Apr 19.PMID: 17446186 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation.

Xu X, Jhun BS, Ha CH, Jin ZG.

Endocrinology. 2008 Aug;149(8):4183-92. Epub 2008 May 1.PMID: 18450953 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.

Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A.

Diabetes. 2007 May;56(5):1387-94. Epub 2007 Feb 7.PMID: 17287464 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress.

Zhang Y, Lee TS, Kolb EM, Sun K, Lu X, Sladek FM, Kassab GS, Garland T Jr, Shyy JY.

Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1281-7. Epub 2006 Apr 6.PMID: 16601232 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling.

Calvert JW, Gundewar S, Jha S, Greer JJ, Bestermann WH, Tian R, Lefer DJ.

Diabetes. 2008 Mar;57(3):696-705. Epub 2007 Dec 14.PMID: 18083782 [PubMed - indexed for MEDLINE]Related articlesFree article

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release.

Fontana J, Fulton D, Chen Y, Fairchild TA, McCabe TJ, Fujita N, Tsuruo T, Sessa WC.

Circ Res. 2002 May 3;90(8):866-73.PMID: 11988487 [PubMed - indexed for MEDLINE]Related articlesFree article