PubMed

MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.

Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R.

Diabetes. 2006 Feb;55(2):297-304.PMID: 16443760 [PubMed - indexed for MEDLINE]Related articlesFree article

Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.

Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM, Sharma A.

Dev Biol. 2008 Feb 15;314(2):443-56. Epub 2007 Dec 23.PMID: 18199433 [PubMed - indexed for MEDLINE]Related articlesFree article

MafB is required for islet beta cell maturation.

Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S, Sieweke M, Stein R.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3853-8. Epub 2007 Feb 22.PMID: 17360442 [PubMed - indexed for MEDLINE]Related articlesFree article

Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development.

Smith SB, Ee HC, Conners JR, German MS.

Mol Cell Biol. 1999 Dec;19(12):8272-80.PMID: 10567552 [PubMed - indexed for MEDLINE]Related articlesFree article

Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.

Doyle MJ, Loomis ZL, Sussel L.

Development. 2007 Feb;134(3):515-23. Epub 2007 Jan 3.PMID: 17202186 [PubMed - indexed for MEDLINE]Related articlesFree article

A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.

Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S, Sharma A.

Dev Biol. 2006 May 15;293(2):526-39. Epub 2006 Apr 3.PMID: 16580660 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic determinants of pancreatic epsilon-cell development.

Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, Serup P.

Dev Biol. 2005 Oct 1;286(1):217-24.PMID: 16122727 [PubMed - indexed for MEDLINE]Related articles

MafA is a dedicated activator of the insulin gene in vivo.

Artner I, Hang Y, Guo M, Gu G, Stein R.

J Endocrinol. 2008 Aug;198(2):271-9. Epub 2008 May 30.PMID: 18515495 [PubMed - indexed for MEDLINE]Related articlesFree article

Pax4 represses pancreatic glucagon gene expression.

Petersen HV, Jørgensen MC, Andersen FG, Jensen J, F-Nielsen T, Jørgensen R, Madsen OD, Serup P.

Mol Cell Biol Res Commun. 2000 Apr;3(4):249-54.PMID: 10891400 [PubMed - indexed for MEDLINE]Related articles

Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells.

Hussain MA, Miller CP, Habener JF.

J Biol Chem. 2002 May 3;277(18):16028-32. Epub 2002 Feb 7.PMID: 11834725 [PubMed - indexed for MEDLINE]Related articlesFree article

The beta-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6.

Gauthier BR, Gosmain Y, Mamin A, Philippe J.

Biochem J. 2007 May 1;403(3):593-601.PMID: 17263687 [PubMed - indexed for MEDLINE]Related articlesFree article

Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet alpha- and beta-cells.

Kataoka K, Shioda S, Ando K, Sakagami K, Handa H, Yasuda K.

J Mol Endocrinol. 2004 Feb;32(1):9-20.PMID: 14765989 [PubMed - indexed for MEDLINE]Related articlesFree article

Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression.

Gosmain Y, Avril I, Mamin A, Philippe J.

J Biol Chem. 2007 Nov 30;282(48):35024-34. Epub 2007 Sep 27.PMID: 17901057 [PubMed - indexed for MEDLINE]Related articlesFree article

The paired homeodomain transcription factor Pax-2 is expressed in the endocrine pancreas and transactivates the glucagon gene promoter.

Ritz-Laser B, Estreicher A, Gauthier B, Philippe J.

J Biol Chem. 2000 Oct 20;275(42):32708-15.PMID: 10938089 [PubMed - indexed for MEDLINE]Related articlesFree article

The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6.

Ritz-Laser B, Estreicher A, Gauthier BR, Mamin A, Edlund H, Philippe J.

Diabetologia. 2002 Jan;45(1):97-107.PMID: 11845228 [PubMed - indexed for MEDLINE]Related articles

The homeodomain of PAX6 is essential for PAX6-dependent activation of the rat glucagon gene promoter: evidence for a PH0-like binding that induces an active conformation.

Grapp M, Teichler S, Kitz J, Dibaj P, Dickel C, Knepel W, Krätzner R.

Biochim Biophys Acta. 2009 May;1789(5):403-12. Epub 2009 Feb 13.PMID: 19217949 [PubMed - indexed for MEDLINE]Related articles

Fibronectin and laminin induce expression of islet cell markers in hepatic oval cells in culture.

Leite AR, Corrêa-Giannella ML, Dagli ML, Fortes MA, Vegas VM, Giannella-Neto D.

Cell Tissue Res. 2007 Mar;327(3):529-37. Epub 2006 Dec 6.PMID: 17149594 [PubMed - indexed for MEDLINE]Related articles

Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells.

Matsuoka TA, Zhao L, Artner I, Jarrett HW, Friedman D, Means A, Stein R.

Mol Cell Biol. 2003 Sep;23(17):6049-62.PMID: 12917329 [PubMed - indexed for MEDLINE]Related articlesFree article

Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas.

St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P.

Nature. 1997 May 22;387(6631):406-9.PMID: 9163426 [PubMed - indexed for MEDLINE]Related articles

A peroxisome proliferator-activated receptor gamma-retinoid X receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene transcription.

Krätzner R, Fröhlich F, Lepler K, Schröder M, Röher K, Dickel C, Tzvetkov MV, Quentin T, Oetjen E, Knepel W.

Mol Pharmacol. 2008 Feb;73(2):509-17. Epub 2007 Oct 25.PMID: 17962386 [PubMed - indexed for MEDLINE]Related articlesFree article