PubMed

Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK).

Karim F, Hu HJ, Adwanikar H, Kaplan D, Gereau RW 4th.

Mol Pain. 2006 Jan 16;2:2.PMID: 16412244 [PubMed - indexed for MEDLINE]Related articlesFree article

ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.

Ji RR, Befort K, Brenner GJ, Woolf CJ.

J Neurosci. 2002 Jan 15;22(2):478-85.PMID: 11784793 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular signaling-regulated kinase-1 and -2 (ERK 1/2) mediate referred hyperalgesia in a murine model of visceral pain.

Galan A, Cervero F, Laird JM.

Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):126-34.PMID: 12941468 [PubMed - indexed for MEDLINE]Related articles

Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia.

Cui XY, Dai Y, Wang SL, Yamanaka H, Kobayashi K, Obata K, Chen J, Noguchi K.

Mol Pain. 2008 Apr 30;4:17.PMID: 18445299 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor.

Tsuda M, Ishii S, Masuda T, Hasegawa S, Nakamura K, Nagata K, Yamashita T, Furue H, Tozaki-Saitoh H, Yoshimura M, Koizumi S, Shimizu T, Inoue K.

J Neurochem. 2007 Sep;102(5):1658-68. Epub 2007 Jul 27.PMID: 17662046 [PubMed - indexed for MEDLINE]Related articles

Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice.

Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S.

Anesth Analg. 2009 Oct;109(4):1305-11.PMID: 19762761 [PubMed - indexed for MEDLINE]Related articles

Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation.

Tang Q, Svensson CI, Fitzsimmons B, Webb M, Yaksh TL, Hua XY.

Eur J Neurosci. 2007 May;25(10):2964-72.PMID: 17561811 [PubMed - indexed for MEDLINE]Related articles

Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma.

Yang R, Piperdi S, Gorlick R.

Clin Cancer Res. 2008 Oct 15;14(20):6396-404.PMID: 18927278 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of spinal ERK signaling pathway contributes to pain-related responses induced by scorpion Buthus martensi Karch venom.

Pang XY, Liu T, Jiang F, Ji YH.

Toxicon. 2008 May;51(6):994-1007. Epub 2008 Jan 17.PMID: 18328523 [PubMed - indexed for MEDLINE]Related articles

Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia.

Hao J, Liu MG, Yu YQ, Cao FL, Li Z, Lu ZM, Chen J.

Neuroscience. 2008 Apr 9;152(4):1067-75. Epub 2008 Jan 9.PMID: 18329815 [PubMed - indexed for MEDLINE]Related articles

Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity.

Ji RR, Baba H, Brenner GJ, Woolf CJ.

Nat Neurosci. 1999 Dec;2(12):1114-9.PMID: 10570489 [PubMed - indexed for MEDLINE]Related articles

Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons.

Hu HJ, Alter BJ, Carrasquillo Y, Qiu CS, Gereau RW 4th.

J Neurosci. 2007 Nov 28;27(48):13181-91.PMID: 18045912 [PubMed - indexed for MEDLINE]Related articlesFree article

c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity.

Doya H, Ohtori S, Fujitani M, Saito T, Hata K, Ino H, Takahashi K, Moriya H, Yamashita T.

Biochem Biophys Res Commun. 2005 Sep 16;335(1):132-8.PMID: 16055088 [PubMed - indexed for MEDLINE]Related articles

Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception.

Carrasquillo Y, Gereau RW 4th.

J Neurosci. 2007 Feb 14;27(7):1543-51.PMID: 17301163 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of TRPV1 contributes to morphine tolerance: involvement of the mitogen-activated protein kinase signaling pathway.

Chen Y, Geis C, Sommer C.

J Neurosci. 2008 May 28;28(22):5836-45.PMID: 18509045 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of retinal neurite growth by alterations in MAPK/ERK kinase (MEK) activity.

Dimitropoulou A, Bixby JL.

Brain Res. 2000 Mar 6;858(1):205-14.PMID: 10700616 [PubMed - indexed for MEDLINE]Related articles

Neuronal MEK is important for normal fear conditioning in mice.

Shalin SC, Zirrgiebel U, Honsa KJ, Julien JP, Miller FD, Kaplan DR, Sweatt JD.

J Neurosci Res. 2004 Mar 15;75(6):760-70.PMID: 14994337 [PubMed - indexed for MEDLINE]Related articles

Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation.

Adwanikar H, Karim F, Gereau RW 4th.

Pain. 2004 Sep;111(1-2):125-35.PMID: 15327816 [PubMed - indexed for MEDLINE]Related articles

Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.

Yip-Schneider MT, Klein PJ, Wentz SC, Zeni A, Menze A, Schmidt CM.

J Pharmacol Exp Ther. 2009 Jun;329(3):1063-70. Epub 2009 Mar 3.PMID: 19258520 [PubMed - indexed for MEDLINE]Related articles

Activation of spinal extracellular signaling-regulated kinases by intraplantar melittin injection.

Yu YQ, Chen J.

Neurosci Lett. 2005 Jun 10-17;381(1-2):194-8. Epub 2005 Mar 2.PMID: 15882816 [PubMed - indexed for MEDLINE]Related articles