PubMed

Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy.

Susztak K, Raff AC, Schiffer M, Böttinger EP.

Diabetes. 2006 Jan;55(1):225-33.PMID: 16380497 [PubMed - indexed for MEDLINE]Related articlesFree article

Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice.

Szabó C, Biser A, Benko R, Böttinger E, Suszták K.

Diabetes. 2006 Nov;55(11):3004-12.PMID: 17065336 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.

Herbach N, Schairer I, Blutke A, Kautz S, Siebert A, Göke B, Wolf E, Wanke R.

Am J Physiol Renal Physiol. 2009 Apr;296(4):F819-29. Epub 2009 Feb 11.PMID: 19211686 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.

Eid AA, Gorin Y, Fagg BM, Maalouf R, Barnes JL, Block K, Abboud HE.

Diabetes. 2009 May;58(5):1201-11. Epub 2009 Feb 10.PMID: 19208908 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease.

Menini S, Iacobini C, Oddi G, Ricci C, Simonelli P, Fallucca S, Grattarola M, Pugliese F, Pesce C, Pugliese G.

Diabetologia. 2007 Dec;50(12):2591-9. Epub 2007 Sep 28.PMID: 17901943 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation endproducts induce podocyte apoptosis by activation of the FOXO4 transcription factor.

Chuang PY, Yu Q, Fang W, Uribarri J, He JC.

Kidney Int. 2007 Oct;72(8):965-76. Epub 2007 Aug 1.PMID: 17667983 [PubMed - indexed for MEDLINE]Related articles

Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: prevention by lipoic acid treatment.

Siu B, Saha J, Smoyer WE, Sullivan KA, Brosius FC 3rd.

BMC Nephrol. 2006 Mar 15;7:6.PMID: 16539708 [PubMed - indexed for MEDLINE]Related articlesFree article

Antioxidants ameliorate the expression of vascular endothelial growth factor mediated by protein kinase C in diabetic podocytes.

Lee EY, Chung CH, Kim JH, Joung HJ, Hong SY.

Nephrol Dial Transplant. 2006 Jun;21(6):1496-503. Epub 2006 Feb 16.PMID: 16484238 [PubMed - indexed for MEDLINE]Related articlesFree article

Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death.

Tejada T, Catanuto P, Ijaz A, Santos JV, Xia X, Sanchez P, Sanabria N, Lenz O, Elliot SJ, Fornoni A.

Kidney Int. 2008 Jun;73(12):1385-93. Epub 2008 Apr 2.PMID: 18385666 [PubMed - indexed for MEDLINE]Related articles

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes.

Koya D, Haneda M, Nakagawa H, Isshiki K, Sato H, Maeda S, Sugimoto T, Yasuda H, Kashiwagi A, Ways DK, King GL, Kikkawa R.

FASEB J. 2000 Mar;14(3):439-47.PMID: 10698958 [PubMed - indexed for MEDLINE]Related articlesFree article

Podocyte-specific overexpression of the antioxidant metallothionein reduces diabetic nephropathy.

Zheng S, Carlson EC, Yang L, Kralik PM, Huang Y, Epstein PN.

J Am Soc Nephrol. 2008 Nov;19(11):2077-85. Epub 2008 Jul 16.PMID: 18632844 [PubMed - indexed for MEDLINE]Related articlesFree article

Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice.

Fujii M, Inoguchi T, Maeda Y, Sasaki S, Sawada F, Saito R, Kobayashi K, Sumimoto H, Takayanagi R.

Kidney Int. 2007 Aug;72(4):473-80. Epub 2007 Jun 13.PMID: 17568784 [PubMed - indexed for MEDLINE]Related articles

Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice.

Lim AK, Nikolic-Paterson DJ, Ma FY, Ozols E, Thomas MC, Flavell RA, Davis RJ, Tesch GH.

Diabetologia. 2009 Feb;52(2):347-58. Epub 2008 Dec 9.PMID: 19066844 [PubMed - indexed for MEDLINE]Related articles

p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency.

Wolf G, Schanze A, Stahl RA, Shankland SJ, Amann K.

Kidney Int. 2005 Oct;68(4):1583-9.PMID: 16164635 [PubMed - indexed for MEDLINE]Related articles

BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury.

Mitu GM, Wang S, Hirschberg R.

Am J Physiol Renal Physiol. 2007 Nov;293(5):F1641-8. Epub 2007 Sep 5.PMID: 17804487 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells.

Mishra R, Emancipator SN, Kern T, Simonson MS.

Kidney Int. 2005 Jan;67(1):82-93.PMID: 15610231 [PubMed - indexed for MEDLINE]Related articles

Podocyte injury promotes progressive nephropathy in zucker diabetic fatty rats.

Hoshi S, Shu Y, Yoshida F, Inagaki T, Sonoda J, Watanabe T, Nomoto K, Nagata M.

Lab Invest. 2002 Jan;82(1):25-35.PMID: 11796823 [PubMed - indexed for MEDLINE]Related articles

Podocyte hypertrophy in diabetic nephropathy.

Kim NH.

Nephrology (Carlton). 2005 Oct;10 Suppl:S14-6. Review.PMID: 16174280 [PubMed - indexed for MEDLINE]Related articles

17 beta-estradiol and tamoxifen upregulate estrogen receptor beta expression and control podocyte signaling pathways in a model of type 2 diabetes.

Catanuto P, Doublier S, Lupia E, Fornoni A, Berho M, Karl M, Striker GE, Xia X, Elliot S.

Kidney Int. 2009 Jun;75(11):1194-201. Epub 2009 Mar 11.PMID: 19279558 [PubMed - indexed for MEDLINE]Related articles

Urocortin ameliorates diabetic nephropathy in obese db/db mice.

Li X, Hu J, Zhang R, Sun X, Zhang Q, Guan X, Chen J, Zhu Q, Li S.

Br J Pharmacol. 2008 Jul;154(5):1025-34. Epub 2008 Apr 21.PMID: 18587447 [PubMed - indexed for MEDLINE]Related articlesFree article