PubMed

Glibenclamide treatment recruits beta-cell subpopulation into elevated and sustained basal insulin synthetic activity.

Ling Z, Wang Q, Stangé G, In't Veld P, Pipeleers D.

Diabetes. 2006 Jan;55(1):78-85.PMID: 16380479 [PubMed - indexed for MEDLINE]Related articlesFree article

Glibenclamide activates translation in rat pancreatic beta cells through calcium-dependent mTOR, PKA and MEK signalling pathways.

Wang Q, Heimberg H, Pipeleers D, Ling Z.

Diabetologia. 2008 Jul;51(7):1202-12. Epub 2008 May 21.PMID: 18493739 [PubMed - indexed for MEDLINE]Related articles

Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells.

Remedi MS, Nichols CG.

PLoS Med. 2008 Oct 28;5(10):e206.PMID: 18959471 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.

Alarcon C, Wicksteed B, Rhodes CJ.

Diabetologia. 2006 Dec;49(12):2920-9. Epub 2006 Oct 20.PMID: 17053883 [PubMed - indexed for MEDLINE]Related articles

Insulin exocytosis in Goto-Kakizaki rat beta-cells subjected to long-term glinide or sulfonylurea treatment.

Kawai J, Ohara-Imaizumi M, Nakamichi Y, Okamura T, Akimoto Y, Matsushima S, Aoyagi K, Kawakami H, Watanabe T, Watada H, Kawamori R, Nagamatsu S.

Biochem J. 2008 May 15;412(1):93-101.PMID: 18254725 [PubMed - indexed for MEDLINE]Related articlesFree article

Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis.

Lehtihet M, Welsh N, Berggren PO, Cook GA, Sjoholm A.

Am J Physiol Endocrinol Metab. 2003 Aug;285(2):E438-46. Epub 2003 Apr 8.PMID: 12684219 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic beta-cell line, MIN6.

Sawada F, Inoguchi T, Tsubouchi H, Sasaki S, Fujii M, Maeda Y, Morinaga H, Nomura M, Kobayashi K, Takayanagi R.

Metabolism. 2008 Aug;57(8):1038-45.PMID: 18640379 [PubMed - indexed for MEDLINE]Related articles

Effects of chronically elevated glucose levels on the functional properties of rat pancreatic beta-cells.

Ling Z, Kiekens R, Mahler T, Schuit FC, Pipeleers-Marichal M, Sener A, Kloppel G, Malaisse WJ, Pipeleers DG.

Diabetes. 1996 Dec;45(12):1774-82.PMID: 8922365 [PubMed - indexed for MEDLINE]Related articles

Disappearance of glibenclamide-induced hypoglycemia in Wistar-Kyoto rats.

Sakamoto K, Yonoki Y, Fujioka T, Matsumura M, Mitsuta Y, Sano M, Saito M, Nakahara T, Ishii K.

Biol Pharm Bull. 2006 Mar;29(3):574-6.PMID: 16508171 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of insulinotrophic actions of nateglinide with glibenclamide dissociated from absorption in conscious dogs.

Okamoto M, Ogihara N, Kawamura W, Ebihara S, Takiguchi K, Morita T, Uchida R, Yamaguchi J, Sakai T, Okuda Y, Hayashi Y, Arakawa Y, Kikuchi M.

Metabolism. 2002 May;51(5):575-81.PMID: 11979388 [PubMed - indexed for MEDLINE]Related articles

Sustained enhancement of Ca(2+) influx by glibenclamide induces apoptosis in RINm5F cells.

Iwakura T, Fujimoto S, Kagimoto S, Inada A, Kubota A, Someya Y, Ihara Y, Yamada Y, Seino Y.

Biochem Biophys Res Commun. 2000 May 10;271(2):422-8.PMID: 10799313 [PubMed - indexed for MEDLINE]Related articles

Exposure to glibenclamide increases rat beta cells sensitivity to glucose.

Patanè G, Piro S, Anello M, Rabuazzo AM, Vigneri R, Purrello F.

Br J Pharmacol. 2000 Mar;129(5):887-92.PMID: 10696086 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfonylurea induced beta-cell apoptosis in cultured human islets.

Maedler K, Carr RD, Bosco D, Zuellig RA, Berney T, Donath MY.

J Clin Endocrinol Metab. 2005 Jan;90(1):501-6. Epub 2004 Oct 13.PMID: 15483097 [PubMed - indexed for MEDLINE]Related articlesFree article

Imaging docking and fusion of insulin granules induced by antidiabetes agents: sulfonylurea and glinide drugs preferentially mediate the fusion of newcomer, but not previously docked, insulin granules.

Nagamatsu S, Ohara-Imaizumi M, Nakamichi Y, Kikuta T, Nishiwaki C.

Diabetes. 2006 Oct;55(10):2819-25.PMID: 17003348 [PubMed - indexed for MEDLINE]Related articlesFree article

Stevioside does not cause increased basal insulin secretion or beta-cell desensitization as does the sulphonylurea, glibenclamide: studies in vitro.

Chen J, Jeppesen PB, Abudula R, Dyrskog SE, Colombo M, Hermansen K.

Life Sci. 2006 Mar 6;78(15):1748-53. Epub 2005 Nov 2.PMID: 16260001 [PubMed - indexed for MEDLINE]Related articles

Sulfonylurea and glinide reduce insulin content, functional expression of K(ATP) channels, and accelerate apoptotic beta-cell death in the chronic phase.

Takahashi A, Nagashima K, Hamasaki A, Kuwamura N, Kawasaki Y, Ikeda H, Yamada Y, Inagaki N, Seino Y.

Diabetes Res Clin Pract. 2007 Sep;77(3):343-50. Epub 2007 Feb 20.PMID: 17316868 [PubMed - indexed for MEDLINE]Related articles

Beneficial effects of Murraya koenigii leaves on antioxidant defense system and ultra structural changes of pancreatic beta-cells in experimental diabetes in rats.

Arulselvan P, Subramanian SP.

Chem Biol Interact. 2007 Jan 30;165(2):155-64. Epub 2006 Dec 2.PMID: 17188670 [PubMed - indexed for MEDLINE]Related articles

Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells.

Wang X, Zhou L, Shao L, Qian L, Fu X, Li G, Luo T, Gu Y, Li F, Li J, Zheng S, Luo M.

Life Sci. 2007 Jun 20;81(2):160-5. Epub 2007 May 6.PMID: 17544010 [PubMed - indexed for MEDLINE]Related articles

Preservation of glucose-responsive islet beta-cells during serum-free culture.

Ling Z, Pipeleers DG.

Endocrinology. 1994 Jun;134(6):2614-21.PMID: 7515006 [PubMed - indexed for MEDLINE]Related articles

Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion.

Patterson S, Flatt PR, Brennan L, Newsholme P, McClenaghan NH.

J Endocrinol. 2006 May;189(2):301-10.PMID: 16648297 [PubMed - indexed for MEDLINE]Related articlesFree article