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    Results: 1 to 20 of 131

    1.

    Evaluation of beta-cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21cip.

    Cozar-Castellano I, Weinstock M, Haught M, Velázquez-Garcia S, Sipula D, Stewart AF.

    Diabetes. 2006 Jan;55(1):70-7.PMID: 16380478 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    The cell cycle inhibitory protein p21cip is not essential for maintaining beta-cell cycle arrest or beta-cell function in vivo.

    Cozar-Castellano I, Haught M, Stewart AF.

    Diabetes. 2006 Dec;55(12):3271-8.PMID: 17130470 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo.

    Fiaschi-Taesch N, Bigatel TA, Sicari B, Takane KK, Salim F, Velazquez-Garcia S, Harb G, Selk K, Cozar-Castellano I, Stewart AF.

    Diabetes. 2009 Apr;58(4):882-93. Epub 2009 Jan 9.PMID: 19136653 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice.

    García-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, López-Talavera JC, Stewart AF.

    Diabetes. 2001 Dec;50(12):2752-62.PMID: 11723058 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis.

    Vasavada RC, Wang L, Fujinaka Y, Takane KK, Rosa TC, Mellado-Gil JM, Friedman PA, Garcia-Ocaña A.

    Diabetes. 2007 Nov;56(11):2732-43. Epub 2007 Aug 8.PMID: 17686945 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells.

    Han J, Tsukada Y, Hara E, Kitamura N, Tanaka T.

    J Biol Chem. 2005 Sep 9;280(36):31548-56. Epub 2005 Jul 13.PMID: 16014626 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice.

    Agudo J, Ayuso E, Jimenez V, Salavert A, Casellas A, Tafuro S, Haurigot V, Ruberte J, Segovia JC, Bueren J, Bosch F.

    Diabetologia. 2008 Oct;51(10):1862-72. Epub 2008 Jul 29.PMID: 18663428 [PubMed - indexed for MEDLINE]Related articles

    8.

    Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest.

    Sheahan S, Bellamy CO, Dunbar DR, Harrison DJ, Prost S.

    BMC Cancer. 2007 Nov 19;7:215.PMID: 18021445 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: a novel role for placental lactogen in pancreatic beta-cell survival.

    Fujinaka Y, Sipula D, Garcia-Ocaña A, Vasavada RC.

    Diabetes. 2004 Dec;53(12):3120-30.PMID: 15561942 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Tissue-specific deletion of the retinoblastoma protein in the pancreatic beta-cell has limited effects on beta-cell replication, mass, and function.

    Vasavada RC, Cozar-Castellano I, Sipula D, Stewart AF.

    Diabetes. 2007 Jan;56(1):57-64.PMID: 17192465 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia.

    Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF.

    J Biol Chem. 2000 Jan 14;275(2):1226-32.PMID: 10625667 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines.

    Cozar-Castellano I, Harb G, Selk K, Takane K, Vasavada R, Sicari B, Law B, Zhang P, Scott DK, Fiaschi-Taesch N, Stewart AF.

    Diabetes. 2008 Nov;57(11):3056-68. Epub 2008 Jul 23.PMID: 18650366 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity.

    Fatrai S, Elghazi L, Balcazar N, Cras-Méneur C, Krits I, Kiyokawa H, Bernal-Mizrachi E.

    Diabetes. 2006 Feb;55(2):318-25.PMID: 16443763 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Cyclin D1 overexpression increases the susceptibility of human U266 myeloma cells to CDK inhibitors through a process involving p130-, p107- and E2F-dependent S phase entry.

    Dai Y, Hamm TE, Dent P, Grant S.

    Cell Cycle. 2006 Feb;5(4):437-46. Epub 2006 Feb 15.PMID: 16479154 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferation.

    Shirako E, Hirayama N, Tsukada Y, Tanaka T, Kitamura N.

    J Cell Biochem. 2008 May 1;104(1):176-88.PMID: 18004740 [PubMed - indexed for MEDLINE]Related articles

    16.

    Suppression of human lens epithelial cell proliferation by proteasome inhibition, a potential defense against posterior capsular opacification.

    Awasthi N, Wagner BJ.

    Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4482-9.PMID: 17003443 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin.

    Abramova MV, Pospelova TV, Nikulenkov FP, Hollander CM, Fornace AJ Jr, Pospelov VA.

    J Biol Chem. 2006 Jul 28;281(30):21040-51. Epub 2006 May 22.PMID: 16717102 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    [E1A oncogene effect on the ability of p21(Waf1) to regulate G1/S arrest in E1A-expressing transformants following irradiation]

    Romanov VS, Brichkina AI, Pospelov VA, Pospelova TV.

    Tsitologiia. 2005;47(12):1063-70. Russian. PMID: 16706194 [PubMed - indexed for MEDLINE]Related articles

    19.

    Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertension.

    Yu L, Quinn DA, Garg HG, Hales CA.

    Biochem Biophys Res Commun. 2006 Jul 14;345(4):1565-72. Epub 2006 May 16.PMID: 16729969 [PubMed - indexed for MEDLINE]Related articles

    20.

    WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.

    Yamada T, Ishihara H, Tamura A, Takahashi R, Yamaguchi S, Takei D, Tokita A, Satake C, Tashiro F, Katagiri H, Aburatani H, Miyazaki J, Oka Y.

    Hum Mol Genet. 2006 May 15;15(10):1600-9. Epub 2006 Mar 28.PMID: 16571599 [PubMed - indexed for MEDLINE]Related articlesFree article

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