PubMed

The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.

Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, Han Y, Taub R, Grimsby J.

Diabetes. 2006 Jan;55(1):1-12. Review.PMID: 16380470 [PubMed - indexed for MEDLINE]Related articlesFree article

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm.

Matschinsky FM.

Diabetes. 1996 Feb;45(2):223-41. Review.PMID: 8549869 [PubMed - indexed for MEDLINE]Related articles

Glucokinase, glucose homeostasis, and diabetes mellitus.

Matschinsky FM.

Curr Diab Rep. 2005 Jun;5(3):171-6. Review.PMID: 15929862 [PubMed - indexed for MEDLINE]Related articles

Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics.

Matschinsky FM.

Diabetes. 2002 Dec;51 Suppl 3:S394-404. Review.PMID: 12475782 [PubMed - indexed for MEDLINE]Related articlesFree article

Small molecule glucokinase activators as glucose lowering agents: a new paradigm for diabetes therapy.

Guertin KR, Grimsby J.

Curr Med Chem. 2006;13(15):1839-43. Review.PMID: 16787225 [PubMed - indexed for MEDLINE]Related articles

Glucokinase and glucose homeostasis: proven concepts and new ideas.

Zelent D, Najafi H, Odili S, Buettger C, Weik-Collins H, Li C, Doliba N, Grimsby J, Matschinsky FM.

Biochem Soc Trans. 2005 Feb;33(Pt 1):306-10.PMID: 15667334 [PubMed - indexed for MEDLINE]Related articles

Small molecule glucokinase activators as novel anti-diabetic agents.

Leighton B, Atkinson A, Coghlan MP.

Biochem Soc Trans. 2005 Apr;33(Pt 2):371-4. Review.PMID: 15787609 [PubMed - indexed for MEDLINE]Related articles

Allosteric activators of glucokinase: potential role in diabetes therapy.

Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF.

Science. 2003 Jul 18;301(5631):370-3.PMID: 12869762 [PubMed - indexed for MEDLINE]Related articlesFree article

Recent advances in glucokinase activators for the treatment of type 2 diabetes.

Pal M.

Drug Discov Today. 2009 Aug;14(15-16):784-92. Epub 2009 Jun 9. Review.PMID: 19520181 [PubMed - indexed for MEDLINE]Related articles

Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM.

J Biol Chem. 2005 Apr 8;280(14):14105-13. Epub 2005 Jan 25.PMID: 15677479 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis.

Davis EA, Cuesta-Muñoz A, Raoul M, Buettger C, Sweet I, Moates M, Magnuson MA, Matschinsky FM.

Diabetologia. 1999 Oct;42(10):1175-86.PMID: 10525657 [PubMed - indexed for MEDLINE]Related articles

Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells.

Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, Dunne MJ.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1208-10. Review.PMID: 17956314 [PubMed - indexed for MEDLINE]Related articles

New perspectives on pancreatic islet glucokinase.

Meglasson MD, Matschinsky FM.

Am J Physiol. 1984 Jan;246(1 Pt 1):E1-13. Review.PMID: 6364828 [PubMed - indexed for MEDLINE]Related articles

[New aspects of pancreatic beta cell functions and their possible therapeutic applications]

Tiedge M.

Dtsch Med Wochenschr. 2006 Dec;131 Suppl 8:S226-30. Review. German. PMID: 17139575 [PubMed - indexed for MEDLINE]Related articles

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase.

Kamata K, Mitsuya M, Nishimura T, Eiki J, Nagata Y.

Structure. 2004 Mar;12(3):429-38.PMID: 15016359 [PubMed - indexed for MEDLINE]Related articles

Glucokinase activators for the potential treatment of type 2 diabetes.

Grimsby J, Berthel SJ, Sarabu R.

Curr Top Med Chem. 2008;8(17):1524-32. Review.PMID: 19075763 [PubMed - indexed for MEDLINE]Related articles

Assessing the potential of glucokinase activators in diabetes therapy.

Matschinsky FM.

Nat Rev Drug Discov. 2009 May;8(5):399-416. Epub 2009 Apr 17. Review.PMID: 19373249 [PubMed - indexed for MEDLINE]Related articles

An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism.

Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, Nishimura T, Eiki J, Nagata Y.

J Biol Chem. 2006 Dec 8;281(49):37668-74. Epub 2006 Oct 6.PMID: 17028192 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel glucokinase activator modulates pancreatic islet and hepatocyte function.

Efanov AM, Barrett DG, Brenner MB, Briggs SL, Delaunois A, Durbin JD, Giese U, Guo H, Radloff M, Gil GS, Sewing S, Wang Y, Weichert A, Zaliani A, Gromada J.

Endocrinology. 2005 Sep;146(9):3696-701. Epub 2005 May 26.PMID: 15919746 [PubMed - indexed for MEDLINE]Related articlesFree article

The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.

Christesen HB, Jacobsen BB, Odili S, Buettger C, Cuesta-Munoz A, Hansen T, Brusgaard K, Massa O, Magnuson MA, Shiota C, Matschinsky FM, Barbetti F.

Diabetes. 2002 Apr;51(4):1240-6.PMID: 11916951 [PubMed - indexed for MEDLINE]Related articlesFree article