PubMed

Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis.

Hollox EJ, Davies J, Griesenbach U, Burgess J, Alton EW, Armour JA.

J Negat Results Biomed. 2005 Dec 7;4:9.PMID: 16336654 [PubMed - indexed for MEDLINE]Related articlesFree article

A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.

Fellermann K, Stange DE, Schaeffeler E, Schmalzl H, Wehkamp J, Bevins CL, Reinisch W, Teml A, Schwab M, Lichter P, Radlwimmer B, Stange EF.

Am J Hum Genet. 2006 Sep;79(3):439-48. Epub 2006 Jul 12.PMID: 16909382 [PubMed - indexed for MEDLINE]Related articlesFree article

High-resolution mapping of the 8p23.1 beta-defensin cluster reveals strictly concordant copy number variation of all genes.

Groth M, Szafranski K, Taudien S, Huse K, Mueller O, Rosenstiel P, Nygren AO, Schreiber S, Birkenmeier G, Platzer M.

Hum Mutat. 2008 Oct;29(10):1247-54.PMID: 18470942 [PubMed - indexed for MEDLINE]Related articles

Screening of copy number polymorphisms in human beta-defensin genes using modified real-time quantitative PCR.

Chen Q, Book M, Fang X, Hoeft A, Stuber F.

J Immunol Methods. 2006 Jan 20;308(1-2):231-40. Epub 2005 Dec 15.PMID: 16380128 [PubMed - indexed for MEDLINE]Related articles

Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster.

Hollox EJ, Armour JA, Barber JC.

Am J Hum Genet. 2003 Sep;73(3):591-600. Epub 2003 Aug 12.PMID: 12916016 [PubMed - indexed for MEDLINE]Related articlesFree article

Distribution of human beta-defensin polymorphisms in various control and cystic fibrosis populations.

Vankeerberghen A, Scudiero O, De Boeck K, Macek M Jr, Pignatti PF, Van Hul N, Nuytten H, Salvatore F, Castaldo G, Zemkova D, Vavrova V, Cassiman JJ, Cuppens H.

Genomics. 2005 May;85(5):574-81.PMID: 15820309 [PubMed - indexed for MEDLINE]Related articles

Expression of human beta defensin (HBD-1 and HBD-2) mRNA in nasal epithelia of adult cystic fibrosis patients, healthy individuals, and individuals with acute cold.

Dauletbaev N, Gropp R, Frye M, Loitsch S, Wagner TO, Bargon J.

Respiration. 2002;69(1):46-51.PMID: 11844962 [PubMed - indexed for MEDLINE]Related articlesFree article

Allelic recombination between distinct genomic locations generates copy number diversity in human beta-defensins.

Abu Bakar S, Hollox EJ, Armour JA.

Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):853-8. Epub 2009 Jan 8.PMID: 19131514 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variants of the copy number polymorphic beta-defensin locus are associated with sporadic prostate cancer.

Huse K, Taudien S, Groth M, Rosenstiel P, Szafranski K, Hiller M, Hampe J, Junker K, Schubert J, Schreiber S, Birkenmeier G, Krawczak M, Platzer M.

Tumour Biol. 2008;29(2):83-92. Epub 2008 Jun 2.PMID: 18515986 [PubMed - indexed for MEDLINE]Related articles

Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23.

Linzmeier RM, Ganz T.

Genomics. 2005 Oct;86(4):423-30.PMID: 16039093 [PubMed - indexed for MEDLINE]Related articles

Accurate determination of copy number variations (CNVs): application to the alpha- and beta-defensin CNVs.

Nuytten H, Wlodarska I, Nackaerts K, Vermeire S, Vermeesch J, Cassiman JJ, Cuppens H.

J Immunol Methods. 2009 May 15;344(1):35-44. Epub 2009 Mar 17.PMID: 19298822 [PubMed - indexed for MEDLINE]Related articles

Psoriasis is associated with increased beta-defensin genomic copy number.

Hollox EJ, Huffmeier U, Zeeuwen PL, Palla R, Lascorz J, Rodijk-Olthuis D, van de Kerkhof PC, Traupe H, de Jongh G, den Heijer M, Reis A, Armour JA, Schalkwijk J.

Nat Genet. 2008 Jan;40(1):23-5. Epub 2007 Dec 2.PMID: 18059266 [PubMed - indexed for MEDLINE]Related articlesFree article

Copy number variation of beta-defensins and relevance to disease.

Hollox EJ.

Cytogenet Genome Res. 2008;123(1-4):148-55. Epub 2009 Mar 11. Review.PMID: 19287149 [PubMed - indexed for MEDLINE]Related articles

Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis.

Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, Wilson JM.

Cell. 1997 Feb 21;88(4):553-60.PMID: 9038346 [PubMed - indexed for MEDLINE]Related articles

Mouse beta defensin-1 is a functional homolog of human beta defensin-1.

Morrison GM, Davidson DJ, Kilanowski FM, Borthwick DW, Crook K, Maxwell AI, Govan JR, Dorin JR.

Mamm Genome. 1998 Jun;9(6):453-7.PMID: 9585433 [PubMed - indexed for MEDLINE]Related articles

Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin.

Jansen PA, Rodijk-Olthuis D, Hollox EJ, Kamsteeg M, Tjabringa GS, de Jongh GJ, van Vlijmen-Willems IM, Bergboer JG, van Rossum MM, de Jong EM, den Heijer M, Evers AW, Bergers M, Armour JA, Zeeuwen PL, Schalkwijk J.

PLoS One. 2009;4(3):e4725. Epub 2009 Mar 6.PMID: 19266104 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of beta-defensin-1 gene polymorphisms with Pseudomonas aeruginosa airway colonization in cystic fibrosis.

Tesse R, Cardinale F, Santostasi T, Polizzi A, Manca A, Mappa L, Iacoviello G, De Robertis F, Logrillo VP, Armenio L.

Genes Immun. 2008 Jan;9(1):57-60. Epub 2007 Oct 25.PMID: 17960157 [PubMed - indexed for MEDLINE]Related articles

Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung.

Bals R, Wang X, Wu Z, Freeman T, Bafna V, Zasloff M, Wilson JM.

J Clin Invest. 1998 Sep 1;102(5):874-80.PMID: 9727055 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of higher DEFB4 genomic copy number with Crohn's disease.

Bentley RW, Pearson J, Gearry RB, Barclay ML, McKinney C, Merriman TR, Roberts RL.

Am J Gastroenterol. 2010 Feb;105(2):354-9. Epub 2009 Oct 6.PMID: 19809410 [PubMed - in process]Related articles

A 450-kb contig of defensin genes on human chromosome 8p23.

Linzmeier R, Ho CH, Hoang BV, Ganz T.

Gene. 1999 Jun 11;233(1-2):205-11.PMID: 10375637 [PubMed - indexed for MEDLINE]Related articles