PubMed

Skeletal muscle insulin signaling defects downstream of phosphatidylinositol 3-kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in HIV lipodystrophy.

Haugaard SB, Andersen O, Madsbad S, Frøsig C, Iversen J, Nielsen JO, Wojtaszewski JF.

Diabetes. 2005 Dec;54(12):3474-83.PMID: 16306364 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients with lipodystrophy involve liver, muscle tissue and pancreatic beta-cells.

Haugaard SB, Andersen O, Dela F, Holst JJ, Storgaard H, Fenger M, Iversen J, Madsbad S.

Eur J Endocrinol. 2005 Jan;152(1):103-12.PMID: 15762193 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects.

Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, Berria R, Belfort R, Kashyap S, Mandarino LJ.

Metabolism. 2004 Sep;53(9):1233-42.PMID: 15334390 [PubMed - indexed for MEDLINE]Related articles

Inhibition of lipolysis stimulates peripheral glucose uptake but has no effect on endogenous glucose production in HIV lipodystrophy.

Lindegaard B, Frøsig C, Petersen AM, Plomgaard P, Ditlevsen S, Mittendorfer B, Van Hall G, Wojtaszewski JF, Pedersen BK.

Diabetes. 2007 Aug;56(8):2070-7. Epub 2007 Jun 29.PMID: 17601993 [PubMed - indexed for MEDLINE]Related articlesFree article

Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise.

Thong FS, Derave W, Kiens B, Graham TE, Ursø B, Wojtaszewski JF, Hansen BF, Richter EA.

Diabetes. 2002 Mar;51(3):583-90.PMID: 11872654 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes.

Storgaard H, Jensen CB, Björnholm M, Song XM, Madsbad S, Zierath JR, Vaag AA.

J Clin Endocrinol Metab. 2004 Mar;89(3):1301-11.PMID: 15001626 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased insulin action in skeletal muscle from patients with McArdle's disease.

Nielsen JN, Vissing J, Wojtaszewski JF, Haller RG, Begum N, Richter EA.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1267-75.PMID: 12006356 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation.

Kruszynska YT, Worrall DS, Ofrecio J, Frias JP, Macaraeg G, Olefsky JM.

J Clin Endocrinol Metab. 2002 Jan;87(1):226-34.PMID: 11788651 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired glucose phosphorylation and transport in skeletal muscle cause insulin resistance in HIV-1-infected patients with lipodystrophy.

Behrens GM, Boerner AR, Weber K, van den Hoff J, Ockenga J, Brabant G, Schmidt RE.

J Clin Invest. 2002 Nov;110(9):1319-27.PMID: 12417571 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected].

Storgaard H, Song XM, Jensen CB, Madsbad S, Björnholm M, Vaag A, Zierath JR.

Diabetes. 2001 Dec;50(12):2770-8. Erratum in: Diabetes 2002 Feb;51(2):552. PMID: 11723060 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160.

Frøsig C, Rose AJ, Treebak JT, Kiens B, Richter EA, Wojtaszewski JF.

Diabetes. 2007 Aug;56(8):2093-102. Epub 2007 May 18.PMID: 17513702 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise.

Howlett KF, Sakamoto K, Yu H, Goodyear LJ, Hargreaves M.

Metabolism. 2006 Aug;55(8):1046-52.PMID: 16839840 [PubMed - indexed for MEDLINE]Related articles

Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action.

Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, Berria R, Belfort R, Mandarino LJ.

J Appl Physiol. 2003 Dec;95(6):2519-29. Epub 2003 Aug 8.PMID: 12909611 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated concentrations of free fatty acids are associated with increased insulin response to standard glucose challenge in human immunodeficiency virus-infected subjects with fat redistribution.

Meininger G, Hadigan C, Laposata M, Brown J, Rabe J, Louca J, Aliabadi N, Grinspoon S.

Metabolism. 2002 Feb;51(2):260-6.PMID: 11833059 [PubMed - indexed for MEDLINE]Related articles

Insulin signalling in skeletal muscle of subjects with or without Type II-diabetes and first degree relatives of patients with the disease.

Meyer MM, Levin K, Grimmsmann T, Beck-Nielsen H, Klein HH.

Diabetologia. 2002 Jun;45(6):813-22. Epub 2002 May 8.PMID: 12107725 [PubMed - indexed for MEDLINE]Related articles

Evidence against a role for insulin-signaling proteins PI 3-kinase and Akt in insulin resistance in human skeletal muscle induced by short-term GH infusion.

Jessen N, Djurhuus CB, Jørgensen JO, Jensen LS, Møller N, Lund S, Schmitz O.

Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E194-9. Epub 2004 Aug 31.PMID: 15339744 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes.

Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB.

J Clin Invest. 1999 Sep;104(6):733-41.PMID: 10491408 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

Højlund K, Glintborg D, Andersen NR, Birk JB, Treebak JT, Frøsig C, Beck-Nielsen H, Wojtaszewski JF.

Diabetes. 2008 Feb;57(2):357-66. Epub 2007 Oct 31.PMID: 17977950 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function.

Andersen O, Haugaard SB, Andersen UB, Friis-Møller N, Storgaard H, Vølund A, Nielsen JO, Iversen J, Madsbad S.

Metabolism. 2003 Oct;52(10):1343-53.PMID: 14564688 [PubMed - indexed for MEDLINE]Related articles

Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle.

Del Aguila LF, Krishnan RK, Ulbrecht JS, Farrell PA, Correll PH, Lang CH, Zierath JR, Kirwan JP.

Am J Physiol Endocrinol Metab. 2000 Jul;279(1):E206-12.PMID: 10893341 [PubMed - indexed for MEDLINE]Related articlesFree article