PubMed

Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver.

Boden G, She P, Mozzoli M, Cheung P, Gumireddy K, Reddy P, Xiang X, Luo Z, Ruderman N.

Diabetes. 2005 Dec;54(12):3458-65.PMID: 16306362 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha.

Itani SI, Ruderman NB, Schmieder F, Boden G.

Diabetes. 2002 Jul;51(7):2005-11.PMID: 12086926 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta.

Lam TK, Yoshii H, Haber CA, Bogdanovic E, Lam L, Fantus IG, Giacca A.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E682-91.PMID: 12217885 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of acetaldehyde and TNF alpha on the inhibitory kappa B-alpha protein and nuclear factor kappa B activation in hepatic stellate cells.

Novitskiy G, Ravi R, Potter JJ, Rennie-Tankersley L, Wang L, Mezey E.

Alcohol Alcohol. 2005 Mar-Apr;40(2):96-101. Epub 2004 Nov 18.PMID: 15550448 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of different free fatty acids on insulin resistance in rats.

Han P, Zhang YY, Lu Y, He B, Zhang W, Xia F.

Hepatobiliary Pancreat Dis Int. 2008 Feb;7(1):91-6.PMID: 18234646 [PubMed - indexed for MEDLINE]Related articlesFree article

Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.

Park E, Wong V, Guan X, Oprescu AI, Giacca A.

J Endocrinol. 2007 Nov;195(2):323-31.PMID: 17951543 [PubMed - indexed for MEDLINE]Related articlesFree article

Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver.

Ye JM, Frangioudakis G, Iglesias MA, Furler SM, Ellis B, Dzamko N, Cooney GJ, Kraegen EW.

Endocrinology. 2002 Dec;143(12):4527-35.PMID: 12446579 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance.

Nagle CA, An J, Shiota M, Torres TP, Cline GW, Liu ZX, Wang S, Catlin RL, Shulman GI, Newgard CB, Coleman RA.

J Biol Chem. 2007 May 18;282(20):14807-15. Epub 2007 Mar 27.PMID: 17389595 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating mononuclear cells in the obese are in a proinflammatory state.

Ghanim H, Aljada A, Hofmeyer D, Syed T, Mohanty P, Dandona P.

Circulation. 2004 Sep 21;110(12):1564-71. Epub 2004 Sep 13.PMID: 15364812 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training.

Sriwijitkamol A, Christ-Roberts C, Berria R, Eagan P, Pratipanawatr T, DeFronzo RA, Mandarino LJ, Musi N.

Diabetes. 2006 Mar;55(3):760-7.PMID: 16505240 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo effects of insulin and free fatty acids on matrix metalloproteinases in rat aorta.

Boden G, Song W, Pashko L, Kresge K.

Diabetes. 2008 Feb;57(2):476-83. Epub 2007 Nov 19.PMID: 18025411 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of free fatty acids on plasma resistin and insulin resistance in awake rats.

Yang G, Li L, Fang C, Zhang L, Li Q, Tang Y, Boden G.

Metabolism. 2005 Sep;54(9):1142-6.PMID: 16125524 [PubMed - indexed for MEDLINE]Related articles

Local activation of the IkappaK-NF-kappaB pathway in muscle does not cause insulin resistance.

Polkinghorne E, Lau Q, Cooney GJ, Kraegen EW, Cleasby ME.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E316-25. Epub 2007 Nov 20.PMID: 18029440 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites.

Lam TK, van de Werve G, Giacca A.

Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E281-90.PMID: 12531742 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects.

Reyna SM, Ghosh S, Tantiwong P, Meka CS, Eagan P, Jenkinson CP, Cersosimo E, Defronzo RA, Coletta DK, Sriwijitkamol A, Musi N.

Diabetes. 2008 Oct;57(10):2595-602. Epub 2008 Jul 15.PMID: 18633101 [PubMed - indexed for MEDLINE]Related articlesFree article

High-fat- and lipid-induced insulin resistance in rats: the comparison of glucose metabolism, plasma resistin and adiponectin levels.

Li L, Yang G, Li Q, Tang Y, Li K.

Ann Nutr Metab. 2006;50(6):499-505. Epub 2006 Dec 21.PMID: 17191023 [PubMed - indexed for MEDLINE]Related articles

Links between enhanced fatty acid flux, protein kinase C and NFkappaB activation, and apoB-lipoprotein production in the fructose-fed hamster model of insulin resistance.

Ragheb R, Medhat AM, Shanab GM, Seoudi DM, Fantus IG.

Biochem Biophys Res Commun. 2008 May 23;370(1):134-9. Epub 2008 Mar 19.PMID: 18358236 [PubMed - indexed for MEDLINE]Related articles

Interaction between free fatty acids and glucose metabolism.

Boden G.

Curr Opin Clin Nutr Metab Care. 2002 Sep;5(5):545-9. Review.PMID: 12172479 [PubMed - indexed for MEDLINE]Related articles

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB.

Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE.

Nat Med. 2005 Feb;11(2):183-90. Epub 2005 Jan 30.PMID: 15685173 [PubMed - indexed for MEDLINE]Related articlesFree article

Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice.

Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T, Sato F, Hirose T, Tanaka Y, Mochizuki H, Kawamori R, Watada H.

Diabetologia. 2007 Jan;50(1):131-41. Epub 2006 Nov 9.PMID: 17093946 [PubMed - indexed for MEDLINE]Related articles