PubMed

A polygenic model of the metabolic syndrome with reduced circulating and intra-adipose glucocorticoid action.

Morton NM, Densmore V, Wamil M, Ramage L, Nichol K, Bünger L, Seckl JR, Kenyon CJ.

Diabetes. 2005 Dec;54(12):3371-8.PMID: 16306351 [PubMed - indexed for MEDLINE]Related articlesFree article

11beta-hydroxysteroid dehydrogenase type 1 and obesity.

Morton NM, Seckl JR.

Front Horm Res. 2008;36:146-64. Review.PMID: 18230901 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome.

Masuzaki H, Flier JS.

Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):255-62. Review.PMID: 14683456 [PubMed - indexed for MEDLINE]Related articles

Down-regulation of adipose 11beta-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease.

Morton NM, Ramage L, Seckl JR.

Endocrinology. 2004 Jun;145(6):2707-12. Epub 2004 Mar 25.PMID: 15044372 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.

Morton NM, Paterson JM, Masuzaki H, Holmes MC, Staels B, Fievet C, Walker BR, Flier JS, Mullins JJ, Seckl JR.

Diabetes. 2004 Apr;53(4):931-8.PMID: 15047607 [PubMed - indexed for MEDLINE]Related articlesFree article

A transgenic model of visceral obesity and the metabolic syndrome.

Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS.

Science. 2001 Dec 7;294(5549):2166-70.PMID: 11739957 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue.

Seckl JR, Morton NM, Chapman KE, Walker BR.

Recent Prog Horm Res. 2004;59:359-93. Review.PMID: 14749510 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome.

Stimson RH, Walker BR.

Minerva Endocrinol. 2007 Sep;32(3):141-59. Review.PMID: 17912154 [PubMed - indexed for MEDLINE]Related articles

Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats.

Drake AJ, Livingstone DE, Andrew R, Seckl JR, Morton NM, Walker BR.

Endocrinology. 2005 Feb;146(2):913-9. Epub 2004 Nov 18.PMID: 15550507 [PubMed - indexed for MEDLINE]Related articlesFree article

Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice.

Nuotio-Antar AM, Hachey DL, Hasty AH.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1517-28. Epub 2007 Sep 18. Erratum in: Am J Physiol Endocrinol Metab. 2008 May;294(5):E993. PMID: 17878220 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity.

Wake DJ, Walker BR.

Endocrine. 2006 Feb;29(1):101-8. Review.PMID: 16622297 [PubMed - indexed for MEDLINE]Related articles

11beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients.

Desbriere R, Vuaroqueaux V, Achard V, Boullu-Ciocca S, Labuhn M, Dutour A, Grino M.

Obesity (Silver Spring). 2006 May;14(5):794-8.PMID: 16855188 [PubMed - indexed for MEDLINE]Related articles

Role of glucocorticoids in the physiopathology of excessive fat deposition and insulin resistance.

Asensio C, Muzzin P, Rohner-Jeanrenaud F.

Int J Obes Relat Metab Disord. 2004 Dec;28 Suppl 4:S45-52. Review.PMID: 15592486 [PubMed - indexed for MEDLINE]Related articles

Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice.

Paterson JM, Morton NM, Fievet C, Kenyon CJ, Holmes MC, Staels B, Seckl JR, Mullins JJ.

Proc Natl Acad Sci U S A. 2004 May 4;101(18):7088-93. Epub 2004 Apr 26.PMID: 15118095 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice.

Morton NM, Holmes MC, Fiévet C, Staels B, Tailleux A, Mullins JJ, Seckl JR.

J Biol Chem. 2001 Nov 2;276(44):41293-300. Epub 2001 Aug 23.PMID: 11546766 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study.

Paulmyer-Lacroix O, Boullu S, Oliver C, Alessi MC, Grino M.

J Clin Endocrinol Metab. 2002 Jun;87(6):2701-5.PMID: 12050237 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose tissue expression of 11beta-hydroxysteroid dehydrogenase type 1 in Cushing's syndrome and in obesity.

Espíndola-Antunes D, Kater CE.

Arq Bras Endocrinol Metabol. 2007 Nov;51(8):1397-403.PMID: 18209879 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific Cushing's syndrome, 11beta-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action.

Stewart PM.

Eur J Endocrinol. 2003 Sep;149(3):163-8.PMID: 12943516 [PubMed - indexed for MEDLINE]Related articlesFree article

Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning.

Walker BR.

Proc Nutr Soc. 2007 Feb;66(1):1-8.PMID: 17343766 [PubMed - indexed for MEDLINE]Related articles

Cortisol--cause and cure for metabolic syndrome?

Walker BR.

Diabet Med. 2006 Dec;23(12):1281-8.PMID: 17116176 [PubMed - indexed for MEDLINE]Related articles