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    Results: 1 to 20 of 313

    1.

    Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.

    Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL.

    Diabetes. 2005 Dec;54 Suppl 2:S97-107. Review.PMID: 16306347 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

    Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

    Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.PMID: 15297438 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.

    Liu D, Cardozo AK, Darville MI, Eizirik DL.

    Endocrinology. 2002 Apr;143(4):1225-34.PMID: 11897677 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.

    Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Théâtre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL.

    Diabetologia. 2008 Jul;51(7):1213-25. Epub 2008 May 8.PMID: 18463842 [PubMed - indexed for MEDLINE]Related articles

    5.

    Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

    Welsh N, Cnop M, Kharroubi I, Bugliani M, Lupi R, Marchetti P, Eizirik DL.

    Diabetes. 2005 Nov;54(11):3238-44.PMID: 16249450 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis.

    Liu D, Darville M, Eizirik DL.

    Endocrinology. 2001 Jun;142(6):2593-9.PMID: 11356709 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    cFLIP protein prevents tumor necrosis factor-alpha-mediated induction of caspase-8-dependent apoptosis in insulin-secreting betaTc-Tet cells.

    Cottet S, Dupraz P, Hamburger F, Dolci W, Jaquet M, Thorens B.

    Diabetes. 2002 Jun;51(6):1805-14.PMID: 12031968 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.

    Ortis F, Cardozo AK, Crispim D, Störling J, Mandrup-Poulsen T, Eizirik DL.

    Mol Endocrinol. 2006 Aug;20(8):1867-79. Epub 2006 Mar 23.PMID: 16556731 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric oxide production.

    Jensen J, Galsgaard ED, Karlsen AE, Lee YC, Nielsen JH.

    J Endocrinol. 2005 Oct;187(1):25-36.PMID: 16214938 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Role of NF-kappaB in beta-cell death.

    Melloul D.

    Biochem Soc Trans. 2008 Jun;36(Pt 3):334-9. Review.PMID: 18481952 [PubMed - indexed for MEDLINE]Related articles

    11.

    Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway.

    Kim EK, Kwon KB, Koo BS, Han MJ, Song MY, Song EK, Han MK, Park JW, Ryu DG, Park BH.

    Int J Biochem Cell Biol. 2007;39(6):1260-75. Epub 2007 Apr 19.PMID: 17521952 [PubMed - indexed for MEDLINE]Related articles

    12.

    Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappaB activation.

    Kim EK, Kwon KB, Han MJ, Song MY, Lee JH, Lv N, Ka SO, Yeom SR, Kwon YD, Ryu DG, Kim KS, Park JW, Park R, Park BH.

    Exp Mol Med. 2007 Apr 30;39(2):149-59.PMID: 17464176 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

    Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY.

    J Clin Invest. 2002 Sep;110(6):851-60.PMID: 12235117 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Death effectors of beta-cell apoptosis in type 1 diabetes.

    Lee MS, Chang I, Kim S.

    Mol Genet Metab. 2004 Sep-Oct;83(1-2):82-92. Review.PMID: 15464423 [PubMed - indexed for MEDLINE]Related articles

    15.

    Radix asari extract protects pancreatic beta cells against cytokine-induced toxicity: implication of the NF-kappaB-iNOS signaling cascade.

    Song MY, Kim KA, Lee SY, Kim EK, Lv N, Lee JH, Park JW, Ryu DG, Kwon KB, Park BH.

    Int J Mol Med. 2007 Nov;20(5):769-75.PMID: 17912472 [PubMed - indexed for MEDLINE]Related articles

    16.

    Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappaB activation.

    Kim EK, Kwon KB, Song MY, Han MJ, Lee JH, Lee YR, Lee JH, Ryu DG, Park BH, Park JW.

    Pancreas. 2007 Nov;35(4):e1-9.PMID: 18090225 [PubMed - indexed for MEDLINE]Related articles

    17.

    The role for endoplasmic reticulum stress in diabetes mellitus.

    Eizirik DL, Cardozo AK, Cnop M.

    Endocr Rev. 2008 Feb;29(1):42-61. Epub 2007 Nov 29. Review.PMID: 18048764 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Perturbations in nuclear factor-kappaB or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death.

    Thomas HE, Angstetra E, Fernandes RV, Mariana L, Irawaty W, Jamieson EL, Dudek NL, Kay TW.

    Immunol Cell Biol. 2006 Feb;84(1):20-7. Epub 2005 Nov 7.PMID: 16277639 [PubMed - indexed for MEDLINE]Related articles

    19.

    Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1.

    Steer SA, Scarim AL, Chambers KT, Corbett JA.

    PLoS Med. 2006 Feb;3(2):e17. Epub 2005 Dec 20.PMID: 16354107 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice.

    Kim S, Kim HS, Chung KW, Oh SH, Yun JW, Im SH, Lee MK, Kim KW, Lee MS.

    Diabetes. 2007 Oct;56(10):2561-8. Epub 2007 Jul 9.PMID: 17620422 [PubMed - indexed for MEDLINE]Related articlesFree article

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