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    Results: 1 to 20 of 203

    1.

    Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice.

    Kubosaki A, Nakamura S, Notkins AL.

    Diabetes. 2005 Dec;54 Suppl 2:S46-51.PMID: 16306340 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.

    Kubosaki A, Gross S, Miura J, Saeki K, Zhu M, Nakamura S, Hendriks W, Notkins AL.

    Diabetes. 2004 Jul;53(7):1684-91.PMID: 15220191 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility.

    Kubosaki A, Nakamura S, Clark A, Morris JF, Notkins AL.

    Endocrinology. 2006 Feb;147(2):811-5. Epub 2005 Nov 3.PMID: 16269463 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.

    Henquin JC, Nenquin M, Szollosi A, Kubosaki A, Notkins AL.

    J Endocrinol. 2008 Mar;196(3):573-81.PMID: 18310453 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion.

    Harashima S, Clark A, Christie MR, Notkins AL.

    Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8704-9. Epub 2005 Jun 6.PMID: 15939893 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion.

    Saeki K, Zhu M, Kubosaki A, Xie J, Lan MS, Notkins AL.

    Diabetes. 2002 Jun;51(6):1842-50.PMID: 12031972 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Detection of proteolytic cleavages of diabetes-associated protein IA-2 beta in the pancreas and the brain using novel anti-IA-2 beta monoclonal antibodies.

    Kawakami T, Saeki K, Takeyama N, Wu G, Sakudo A, Matsumoto Y, Hayashi T, Onodera T.

    Int J Mol Med. 2007 Aug;20(2):177-85.PMID: 17611635 [PubMed - indexed for MEDLINE]Related articles

    8.

    Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway.

    Kim SM, Theilig F, Qin Y, Cai T, Mizel D, Faulhaber-Walter R, Hirai H, Bachmann S, Briggs JP, Notkins AL, Schnermann J.

    Am J Physiol Renal Physiol. 2009 Feb;296(2):F382-9. Epub 2008 Nov 19.PMID: 19019914 [PubMed - indexed for MEDLINE]Related articles

    9.

    Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.

    Nishimura T, Kubosaki A, Ito Y, Notkins AL.

    Neuroscience. 2009 Mar 17;159(2):427-37.PMID: 19361477 [PubMed - indexed for MEDLINE]Related articles

    10.

    Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes.

    Trembleau S, Penna G, Gregori S, Magistrelli G, Isacchi A, Adorini L.

    J Immunol. 2000 Dec 15;165(12):6748-55.PMID: 11120794 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Characterization of antibody responses to endogenous and exogenous antigen in the nonobese diabetic mouse.

    Koczwara K, Schenker M, Schmid S, Kredel K, Ziegler AG, Bonifacio E.

    Clin Immunol. 2003 Feb;106(2):155-62.PMID: 12672406 [PubMed - indexed for MEDLINE]Related articles

    12.

    IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.

    Doi A, Shono T, Nishi M, Furuta H, Sasaki H, Nanjo K.

    Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):885-90. Epub 2006 Jan 17.PMID: 16418280 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.

    Lu J, Li Q, Xie H, Chen ZJ, Borovitskaya AE, Maclaren NK, Notkins AL, Lan MS.

    Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2307-11.PMID: 8637868 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    IA-2 is not required for the development of diabetes in NOD mice.

    Kubosaki A, Miura J, Notkins AL.

    Diabetologia. 2004 Jan;47(1):149-50. Epub 2003 Nov 12. No abstract available. PMID: 14614561 [PubMed - indexed for MEDLINE]Related articles

    15.

    Comparison of IA-2 with IA-2beta and with six other members of the protein tyrosine phosphatase family: recognition of antigenic determinants by IDDM sera.

    Notkins AL, Zhang B, Matsumoto Y, Lan MS.

    J Autoimmun. 1997 Jun;10(3):245-50.PMID: 9218750 [PubMed - indexed for MEDLINE]Related articles

    16.

    Human monoclonal antibodies isolated from type I diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen.

    Kolm-Litty V, Berlo S, Bonifacio E, Bearzatto M, Engel AM, Christie M, Ziegler AG, Wild T, Endl J.

    J Immunol. 2000 Oct 15;165(8):4676-84.PMID: 11035111 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.

    Seissler J, Nguyen TB, Aust G, Steinbrenner H, Scherbaum WA.

    Diabetes. 2000 Jul;49(7):1137-41.PMID: 10909970 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Mapping of novel autoreactive epitopes of the diabetes-associated autoantigen IA-2.

    Seissler J, Schott M, Morgenthaler NG, Scherbaum WA.

    Clin Exp Immunol. 2000 Nov;122(2):157-63.PMID: 11091269 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    The IA-2 interactome.

    Hu YF, Zhang HL, Cai T, Harashima S, Notkins AL.

    Diabetologia. 2005 Dec;48(12):2576-81. Epub 2005 Nov 5.PMID: 16273344 [PubMed - indexed for MEDLINE]Related articles

    20.

    A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell antigen 512 (IA-2) and phogrin (IA-2beta).

    Drake PG, Peters GH, Andersen HS, Hendriks W, Møller NP.

    Biochem J. 2003 Jul 15;373(Pt 2):393-401.PMID: 12697028 [PubMed - indexed for MEDLINE]Related articlesFree article

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