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    Results: 1 to 20 of 243

    1.

    Class III alleles at the insulin VNTR polymorphism are associated with regulatory T-cell responses to proinsulin epitopes in HLA-DR4, DQ8 individuals.

    Durinovic-Belló I, Jelinek E, Schlosser M, Eiermann T, Boehm BO, Karges W, Marchand L, Polychronakos C.

    Diabetes. 2005 Dec;54 Suppl 2:S18-24.PMID: 16306335 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes.

    Durinovic-Belló I, Schlosser M, Riedl M, Maisel N, Rosinger S, Kalbacher H, Deeg M, Ziegler M, Elliott J, Roep BO, Karges W, Boehm BO.

    Diabetologia. 2004 Mar;47(3):439-50. Epub 2004 Jan 24.PMID: 14745491 [PubMed - indexed for MEDLINE]Related articles

    3.

    IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity.

    Walter M, Albert E, Conrad M, Keller E, Hummel M, Ferber K, Barratt BJ, Todd JA, Ziegler AG, Bonifacio E.

    Diabetologia. 2003 May;46(5):712-20. Epub 2003 May 16.PMID: 12750767 [PubMed - indexed for MEDLINE]Related articles

    4.

    HLA DRB1, DQB1 and insulin promoter VNTR polymorphisms: interactions and the association with adult-onset diabetes mellitus in Czech patients.

    Cejkova P, Novota P, Cerna M, Kolostova K, Novakova D, Kucera P, Novak J, Andel M, Weber P, Zdarsky E.

    Int J Immunogenet. 2008 Apr;35(2):133-40. Epub 2008 Feb 11.PMID: 18279373 [PubMed - indexed for MEDLINE]Related articles

    5.

    T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin.

    Congia M, Patel S, Cope AP, De Virgiliis S, Sønderstrup G.

    Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3833-8.PMID: 9520453 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

    Pugliese A, Zeller M, Fernandez A Jr, Zalcberg LJ, Bartlett RJ, Ricordi C, Pietropaolo M, Eisenbarth GS, Bennett ST, Patel DD.

    Nat Genet. 1997 Mar;15(3):293-7.PMID: 9054945 [PubMed - indexed for MEDLINE]Related articles

    7.

    Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.

    Vafiadis P, Ounissi-Benkalha H, Palumbo M, Grabs R, Rousseau M, Goodyer CG, Polychronakos C.

    J Clin Endocrinol Metab. 2001 Aug;86(8):3705-10.PMID: 11502799 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Autoimmune responses to the beta cell autoantigen, insulin, and the INS VNTR-IDDM2 locus.

    Sarugeri E, Dozio N, Belloni C, Meschi F, Pastore MR, Bonifacio E.

    Clin Exp Immunol. 1998 Dec;114(3):370-6.PMID: 9844045 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Impact of IDDM2 on disease pathogenesis and progression in children with newly diagnosed type 1 diabetes: reduced insulin antibody titres and preserved beta cell function.

    Nielsen LB, Mortensen HB, Chiarelli F, Holl R, Swift P, de Beaufort C, Pociot F, Hougaard P, Gammeltoft S, Knip M, Hansen L; Hvidøre Study Group.

    Diabetologia. 2006 Jan;49(1):71-4. Epub 2005 Nov 23.PMID: 16307231 [PubMed - indexed for MEDLINE]Related articles

    10.

    Th2 dominance of T helper cell response to preproinsulin in individuals with preclinical type 1 diabetes.

    Durinovic-Belló I, Riedl M, Rosinger S, Maisel N, Kalbacher H, Deeg M, Schreckling HJ, Schlosser M, Ziegler M, Kuehnl P, Boehm BO.

    Ann N Y Acad Sci. 2002 Apr;958:209-13.PMID: 12021108 [PubMed - indexed for MEDLINE]Related articles

    11.

    Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release.

    Hansen SK, Gjesing AP, Rasmussen SK, Glümer C, Urhammer SA, Andersen G, Rose CS, Drivsholm T, Torekov SK, Jensen DP, Ekstrøm CT, Borch-Johnsen K, Jørgensen T, McCarthy MI, Hansen T, Pedersen O.

    Diabetologia. 2004 Jun;47(6):1079-87. Epub 2004 May 29.PMID: 15170498 [PubMed - indexed for MEDLINE]Related articles

    12.

    Relationship between T and B cell responses to proinsulin in human type 1 diabetes.

    Durinovic-Belló I, Maisel N, Schlosser M, Kalbacher H, Deeg M, Eiermann T, Karges W, Boehm BO.

    Ann N Y Acad Sci. 2003 Nov;1005:288-94.PMID: 14679078 [PubMed - indexed for MEDLINE]Related articles

    13.

    Reduced CCR4, interleukin-13 and GATA-3 up-regulation in response to type 2 cytokines of cord blood T lymphocytes in infants at genetic risk of type 1 diabetes.

    Luopajärvi K, Skarsvik S, Ilonen J, Akerblom HK, Vaarala O.

    Immunology. 2007 Jun;121(2):189-96. Epub 2007 Jan 18.PMID: 17244154 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Predominantly recognized proinsulin T helper cell epitopes in individuals with and without islet cell autoimmunity.

    Durinovic-Belló I, Boehm BO, Ziegler AG.

    J Autoimmun. 2002 Feb;18(1):55-66.PMID: 11869047 [PubMed - indexed for MEDLINE]Related articles

    15.

    T cell recognition of human pre-proinsulin peptides depends on the polymorphism at HLA DQ locus: a study using HLA DQ8 and DQ6 transgenic mice.

    Raju R, Munn SR, David CS.

    Hum Immunol. 1997 Nov;58(1):21-9.PMID: 9438206 [PubMed - indexed for MEDLINE]Related articles

    16.

    INS VNTR allelic variation and dynamic insulin secretion in healthy adult non-diabetic Caucasian subjects.

    Ahmed S, Bennett ST, Huxtable SJ, Todd JA, Matthews DR, Gough SC.

    Diabet Med. 1999 Nov;16(11):910-7.PMID: 10588520 [PubMed - indexed for MEDLINE]Related articles

    17.

    IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.

    Bennett ST, Wilson AJ, Cucca F, Nerup J, Pociot F, McKinney PA, Barnett AH, Bain SC, Todd JA.

    J Autoimmun. 1996 Jun;9(3):415-21.PMID: 8816980 [PubMed - indexed for MEDLINE]Related articles

    18.

    The relation between size at birth and risk of type 1 diabetes is not influenced by adjustment for the insulin gene (-23HphI) polymorphism or HLA-DQ genotype.

    Stene LC, Thorsby PM, Berg JP, Rønningen KS, Undlien DE, Joner G; Norwegian Childhood Diabetes Study Group.

    Diabetologia. 2006 Sep;49(9):2068-73. Epub 2006 May 12.PMID: 16691379 [PubMed - indexed for MEDLINE]Related articles

    19.

    In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.

    Metcalfe KA, Hitman GA, Fennessy MJ, McCarthy MI, Tuomilehto J, Tuomilehto-Wolf E.

    Diabetologia. 1995 Oct;38(10):1223-9.PMID: 8690176 [PubMed - indexed for MEDLINE]Related articles

    20.

    Variable number of tandem repeats of the insulin gene determines susceptibility to latent autoimmune diabetes in adults.

    Cerrone GE, Caputo M, Lopez AP, González C, Massa C, Cédola N, Targovnik HM, Frechtel GD.

    Mol Diagn. 2004;8(1):43-9.PMID: 15230641 [PubMed - indexed for MEDLINE]Related articles

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