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Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease).

Abrera-Abeleda MA, Nishimura C, Smith JL, Sethi S, McRae JL, Murphy BF, Silvestri G, Skerka C, Józsi M, Zipfel PF, Hageman GS, Smith RJ.

J Med Genet. 2006 Jul;43(7):582-9. Epub 2005 Nov 18.PMID: 16299065 [PubMed - indexed for MEDLINE]Related articlesFree article

Hereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis.

Licht C, Fremeaux-Bacchi V.

Thromb Haemost. 2009 Feb;101(2):271-8. Review.PMID: 19190809 [PubMed - indexed for MEDLINE]Related articles

Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome.

Servais A, Frémeaux-Bacchi V, Lequintrec M, Salomon R, Blouin J, Knebelmann B, Grünfeld JP, Lesavre P, Noël LH, Fakhouri F.

J Med Genet. 2007 Mar;44(3):193-9. Epub 2006 Oct 3.PMID: 17018561 [PubMed - indexed for MEDLINE]Related articles

Genetic deficiency of complement factor H in a patient with age-related macular degeneration and membranoproliferative glomerulonephritis.

Montes T, Goicoechea de Jorge E, Ramos R, Gomà M, Pujol O, Sánchez-Corral P, Rodríguez de Córdoba S.

Mol Immunol. 2008 May;45(10):2897-904. Epub 2008 Mar 12.PMID: 18336910 [PubMed - indexed for MEDLINE]Related articles

Dense deposit disease and the factor H H402 allele.

Lau KK, Smith RJ, Kolbeck PC, Butani L.

Clin Exp Nephrol. 2008 Jun;12(3):228-32. Epub 2008 Jan 26.PMID: 18224273 [PubMed - indexed for MEDLINE]Related articles

The spectrum of phenotypes caused by variants in the CFH gene.

Boon CJ, van de Kar NC, Klevering BJ, Keunen JE, Cremers FP, Klaver CC, Hoyng CB, Daha MR, den Hollander AI.

Mol Immunol. 2009 May;46(8-9):1573-94. Epub 2009 Mar 17. Review.PMID: 19297022 [PubMed - indexed for MEDLINE]Related articles

Factor H genotype-phenotype correlations: lessons from aHUS, MPGN II, and AMD.

Goodship TH.

Kidney Int. 2006 Jul;70(1):12-3.PMID: 16810287 [PubMed - indexed for MEDLINE]Related articles

MPGN II--genetically determined by defective complement regulation?

Licht C, Schlötzer-Schrehardt U, Kirschfink M, Zipfel PF, Hoppe B.

Pediatr Nephrol. 2007 Jan;22(1):2-9. Epub 2006 Sep 23.PMID: 17024390 [PubMed - indexed for MEDLINE]Related articles

Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.

de Córdoba SR, de Jorge EG.

Clin Exp Immunol. 2008 Jan;151(1):1-13. Review.PMID: 18081690 [PubMed - indexed for MEDLINE]Related articlesFree article

The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models.

Saunders RE, Abarrategui-Garrido C, Frémeaux-Bacchi V, Goicoechea de Jorge E, Goodship TH, López Trascasa M, Noris M, Ponce Castro IM, Remuzzi G, Rodríguez de Córdoba S, Sánchez-Corral P, Skerka C, Zipfel PF, Perkins SJ.

Hum Mutat. 2007 Mar;28(3):222-34.PMID: 17089378 [PubMed - indexed for MEDLINE]Related articles

Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals.

Pickering MC, Cook HT.

Clin Exp Immunol. 2008 Feb;151(2):210-30. Review.PMID: 18190458 [PubMed - indexed for MEDLINE]Related articlesFree article

[Familial membranoproliferative glomerulonephritis]

Bogdanović RM, Dimitrjević JZ, Nikolić VN, Ognjanović MV, Rodić BD, Slavković BV.

Srp Arh Celok Lek. 1999 May-Jun;127(5-6):163-71. Serbian. PMID: 10500423 [PubMed - indexed for MEDLINE]Related articles

Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II).

Licht C, Heinen S, Józsi M, Löschmann I, Saunders RE, Perkins SJ, Waldherr R, Skerka C, Kirschfink M, Hoppe B, Zipfel PF.

Kidney Int. 2006 Jul;70(1):42-50. Epub 2006 Apr 12.PMID: 16612335 [PubMed - indexed for MEDLINE]Related articles

Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population.

Chu J, Zhou CC, Lu N, Zhang X, Dong FT.

Chin Med J (Engl). 2008 Dec 20;121(24):2525-33.PMID: 19187590 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome.

Monteferrante G, Brioschi S, Caprioli J, Pianetti G, Bettinaglio P, Bresin E, Remuzzi G, Noris M.

Mol Immunol. 2007 Mar;44(7):1704-8. Epub 2006 Sep 26.PMID: 17000000 [PubMed - indexed for MEDLINE]Related articles

Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H.

Pickering MC, Cook HT, Warren J, Bygrave AE, Moss J, Walport MJ, Botto M.

Nat Genet. 2002 Aug;31(4):424-8. Epub 2002 Jul 1.PMID: 12091909 [PubMed - indexed for MEDLINE]Related articles

Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population.

Xu Y, Guan N, Xu J, Yang X, Ma K, Zhou H, Zhang F, Snellingen T, Jiao Y, Liu X, Wang N, Liu N.

Mol Vis. 2008 Jul 28;14:1373-81.PMID: 18682812 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice.

Pickering MC, Warren J, Rose KL, Carlucci F, Wang Y, Walport MJ, Cook HT, Botto M.

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9649-54. Epub 2006 Jun 12.PMID: 16769899 [PubMed - indexed for MEDLINE]Related articlesFree article

Membranoproliferative glomerulonephritis type II (dense deposit disease): an update.

Appel GB, Cook HT, Hageman G, Jennette JC, Kashgarian M, Kirschfink M, Lambris JD, Lanning L, Lutz HU, Meri S, Rose NR, Salant DJ, Sethi S, Smith RJ, Smoyer W, Tully HF, Tully SP, Walker P, Welsh M, Würzner R, Zipfel PF.

J Am Soc Nephrol. 2005 May;16(5):1392-403. Epub 2005 Mar 30. Review.PMID: 15800116 [PubMed - indexed for MEDLINE]Related articlesFree article

Glomerular paramesangial deposits: association with hypocomplementemia in membranoproliferative glomerulonephritis types I and III.

West CD, McAdams AJ.

Am J Kidney Dis. 1998 Mar;31(3):427-34.PMID: 9506679 [PubMed - indexed for MEDLINE]Related articles