PubMed

Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b.

Dulos J, Kaptein A, Kavelaars A, Heijnen C, Boots A.

Arthritis Res Ther. 2005;7(6):R1271-80. Epub 2005 Sep 15.PMID: 16277680 [PubMed - indexed for MEDLINE]Related articlesFree article

DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad.

Dulos J, Boots AH.

Ann N Y Acad Sci. 2006 Jun;1069:401-13.PMID: 16855167 [PubMed - indexed for MEDLINE]Related articles

CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.

Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM.

Arthritis Rheum. 2005 Mar;52(3):770-8.PMID: 15751070 [PubMed - indexed for MEDLINE]Related articlesFree article

Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1beta.

Dulos J, Verbraak E, Bagchus WM, Boots AM, Kaptein A.

Arthritis Rheum. 2004 Oct;50(10):3346-53.PMID: 15476247 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes.

Xu H, He Y, Yang X, Liang L, Zhan Z, Ye Y, Yang X, Lian F, Sun L.

Rheumatology (Oxford). 2007 Jun;46(6):920-6. Epub 2007 Feb 21.PMID: 17314215 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid-mediated repression of inflammatory cytokine production in fibroblast-like rheumatoid synoviocytes is independent of nuclear factor-kappaB activation induced by tumour necrosis factor alpha.

Han CW, Choi JH, Kim JM, Kim WY, Lee KY, Oh GT.

Rheumatology (Oxford). 2001 Mar;40(3):267-73.PMID: 11285373 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin (IL)-23 p19 expression induced by IL-1beta in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-kappaB and AP-1 dependent pathway.

Liu FL, Chen CH, Chu SJ, Chen JH, Lai JH, Sytwu HK, Chang DM.

Rheumatology (Oxford). 2007 Aug;46(8):1266-73. Epub 2007 Jun 14.PMID: 17569750 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes.

Granet C, Maslinski W, Miossec P.

Arthritis Res Ther. 2004;6(3):R190-8. Epub 2004 Feb 26.PMID: 15142264 [PubMed - indexed for MEDLINE]Related articlesFree article

Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-alpha. Effects dependent on activation of NF-kappaB and MAP kinases.

Brechter AB, Persson E, Lundgren I, Lerner UH.

Bone. 2008 Jul;43(1):72-83. Epub 2008 Mar 10.PMID: 18467203 [PubMed - indexed for MEDLINE]Related articles

Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships.

Chen CC, Chow MP, Huang WC, Lin YC, Chang YJ.

Mol Pharmacol. 2004 Sep;66(3):683-93.PMID: 15322261 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation.

Cortez DM, Feldman MD, Mummidi S, Valente AJ, Steffensen B, Vincenti M, Barnes JL, Chandrasekar B.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3356-65. Epub 2007 Oct 5.PMID: 17921324 [PubMed - indexed for MEDLINE]Related articlesFree article

TNF-alpha, inefficient by itself, potentiates IL-1beta-induced PGHS-2 expression in human pulmonary microvascular endothelial cells: requirement of NF-kappaB and p38 MAPK pathways.

Said FA, Werts C, Elalamy I, Couetil JP, Jacquemin C, Hatmi M.

Br J Pharmacol. 2002 Aug;136(7):1005-14.PMID: 12145100 [PubMed - indexed for MEDLINE]Related articlesFree article

Amplification of the synovial inflammatory response through activation of mitogen-activated protein kinases and nuclear factor kappaB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis.

Harigai M, Hara M, Kawamoto M, Kawaguchi Y, Sugiura T, Tanaka M, Nakagawa M, Ichida H, Takagi K, Higami-Ohsako S, Shimada K, Kamatani N.

Arthritis Rheum. 2004 Jul;50(7):2167-77.PMID: 15248214 [PubMed - indexed for MEDLINE]Related articlesFree article

Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1.

Grall F, Gu X, Tan L, Cho JY, Inan MS, Pettit AR, Thamrongsak U, Choy BK, Manning C, Akbarali Y, Zerbini L, Rudders S, Goldring SR, Gravallese EM, Oettgen P, Goldring MB, Libermann TA.

Arthritis Rheum. 2003 May;48(5):1249-60.PMID: 12746898 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular heat shock protein 70 inhibits tumour necrosis factor-alpha induced proinflammatory mediator production in fibroblast-like synoviocytes.

Luo X, Zuo X, Zhou Y, Zhang B, Shi Y, Liu M, Wang K, McMillian DR, Xiao X.

Arthritis Res Ther. 2008;10(2):R41. Epub 2008 Apr 14.PMID: 18410682 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: the dominant role for NF-kappa B but not C/EBP beta or c-Jun.

Georganas C, Liu H, Perlman H, Hoffmann A, Thimmapaya B, Pope RM.

J Immunol. 2000 Dec 15;165(12):7199-206.PMID: 11120852 [PubMed - indexed for MEDLINE]Related articlesFree article

A Mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-kappaB activity and cytokine secretion in macrophages via the activation of mitogen-activated protein kinase pathways.

Garcia J, Lemercier B, Roman-Roman S, Rawadi G.

J Biol Chem. 1998 Dec 18;273(51):34391-8.PMID: 9852105 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17.

Hashizume M, Hayakawa N, Mihara M.

Rheumatology (Oxford). 2008 Nov;47(11):1635-40. Epub 2008 Sep 11.PMID: 18786965 [PubMed - indexed for MEDLINE]Related articles

Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression.

Cho ML, Min SY, Chang SH, Kim KW, Heo SB, Lee SH, Park SH, Cho CS, Kim HY.

Immunol Lett. 2006 Jun 15;105(2):159-66. Epub 2006 Mar 3.PMID: 16564576 [PubMed - indexed for MEDLINE]Related articles

Differential regulation of RANTES and IL-8 expression in lung adenocarcinoma cells.

Henriquet C, Gougat C, Combes A, Lazennec G, Mathieu M.

Lung Cancer. 2007 May;56(2):167-74. Epub 2007 Jan 17.PMID: 17207890 [PubMed - indexed for MEDLINE]Related articlesFree article