PubMed

Sequence variation in PPARG may underlie differential response to troglitazone.

Wolford JK, Yeatts KA, Dhanjal SK, Black MH, Xiang AH, Buchanan TA, Watanabe RM.

Diabetes. 2005 Nov;54(11):3319-25.PMID: 16249460 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of Diabetes (TRIPOD) study.

Snitker S, Watanabe RM, Ani I, Xiang AH, Marroquin A, Ochoa C, Goico J, Shuldiner AR, Buchanan TA; Troglitazone in Prevention of Diabetes (TRIPOD) study.

Diabetes Care. 2004 Jun;27(6):1365-8.PMID: 15161789 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.

Florez JC, Jablonski KA, Sun MW, Bayley N, Kahn SE, Shamoon H, Hamman RF, Knowler WC, Nathan DM, Altshuler D; Diabetes Prevention Program Research Group.

J Clin Endocrinol Metab. 2007 Apr;92(4):1502-9. Epub 2007 Jan 9.PMID: 17213274 [PubMed - indexed for MEDLINE]Related articlesFree article

The Pro12Ala variant of the PPARG gene is a risk factor for peroxisome proliferator-activated receptor-gamma/alpha agonist-induced edema in type 2 diabetic patients.

Hansen L, Ekstrøm CT, Tabanera Y Palacios R, Anant M, Wassermann K, Reinhardt RR.

J Clin Endocrinol Metab. 2006 Sep;91(9):3446-50. Epub 2006 Jul 5.PMID: 16822823 [PubMed - indexed for MEDLINE]Related articlesFree article

The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program.

Franks PW, Jablonski KA, Delahanty L, Hanson RL, Kahn SE, Altshuler D, Knowler WC, Florez JC; Diabetes Prevention Program Research Group.

Diabetologia. 2007 Dec;50(12):2451-60. Epub 2007 Sep 27.PMID: 17898990 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacogenetics of thiazolidinedione therapy.

Aquilante CL.

Pharmacogenomics. 2007 Aug;8(8):917-31. Review.PMID: 17716227 [PubMed - indexed for MEDLINE]Related articles

Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes.

Doney AS, Fischer B, Cecil JE, Boylan K, McGuigan FE, Ralston SH, Morris AD, Palmer CN.

Diabetologia. 2004 Mar;47(3):555-8. Epub 2004 Jan 17.PMID: 14730381 [PubMed - indexed for MEDLINE]Related articles

Utilization and costs for compliant patients initiating therapy with pioglitazone or rosiglitazone versus insulin in a Medicaid fee-for-service population.

Kalsekar I, Iyer S, Mody R, Rajagopalan R, Kavookjian J.

J Manag Care Pharm. 2006 Mar;12(2):121-9.PMID: 16515370 [PubMed - indexed for MEDLINE]Related articlesFree article

Troglitazone regulates peroxisome proliferator-activated receptors and inducible nitric oxide synthase in murine ovarian macrophages.

Minge CE, Ryan NK, Van Der Hoek KH, Robker RL, Norman RJ.

Biol Reprod. 2006 Jan;74(1):153-60. Epub 2005 Sep 28.PMID: 16192401 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of thiazolidinediones on blood pressure.

Giles TD, Sander GE.

Curr Hypertens Rep. 2007 Aug;9(4):332-7. Review.PMID: 17686386 [PubMed - indexed for MEDLINE]Related articles

Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues.

LeBrasseur NK, Kelly M, Tsao TS, Farmer SR, Saha AK, Ruderman NB, Tomas E.

Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E175-81. Epub 2006 Feb 7.PMID: 16464908 [PubMed - indexed for MEDLINE]Related articlesFree article

Variation within the PPARG gene is associated with residual beta-cell function and glycemic control in children and adolescents during the first year of clinical type 1 diabetes.

Pörksen S, Nielsen LB, Mortensen HB, Danne T, Kocova M, Castaño L, Pociot F, Hougaard P, Ekstrøm CT, Gammeltoft S, Knip M, Hansen L; Hvidøre Study Group on Childhood Diabetes.

Pediatr Diabetes. 2008 Jul 28;9(4 Pt 1):297-302. Epub 2008 May 7.PMID: 18466209 [PubMed - indexed for MEDLINE]Related articles

The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study.

Jaziri R, Lobbens S, Aubert R, Péan F, Lahmidi S, Vaxillaire M, Porchay I, Bellili N, Tichet J, Balkau B, Froguel P, Marre M, Fumeron F; DESIR Study Group.

Diabetes. 2006 Apr;55(4):1157-62.PMID: 16567542 [PubMed - indexed for MEDLINE]Related articlesFree article

The Pro12Ala and C-681G variants of the PPARG locus are associated with opposing growth phenotypes in young schoolchildren.

Cecil JE, Fischer B, Doney AS, Hetherington M, Watt P, Wrieden W, Bolton-Smith C, Palmer CN.

Diabetologia. 2005 Aug;48(8):1496-502. Epub 2005 Jul 9.PMID: 16007414 [PubMed - indexed for MEDLINE]Related articles

Troglitazone inhibits synthesis of transforming growth factor-beta1 and reduces matrix production in human peritoneal mesothelial cells.

Peng Y, Liu H, Liu F, Liu Y, Li J, Chen X.

Nephrology (Carlton). 2006 Dec;11(6):516-23.PMID: 17199790 [PubMed - indexed for MEDLINE]Related articles

The C161-->T polymorphism in peroxisome proliferator-activated receptor gamma, but not P12A, is associated with insulin resistance in Hispanic and non-Hispanic white women: evidence for another functional variant in peroxisome proliferator-activated receptor gamma.

Moffett SP, Feingold E, Barmada MM, Damcott CM, Marshall JA, Hamman RF, Ferrell RE.

Metabolism. 2005 Nov;54(11):1552-6.PMID: 16253648 [PubMed - indexed for MEDLINE]Related articles

Relationship between two sequence variations in the gene for peroxisome proliferator-activated receptor-gamma and plasma homocysteine concentration. Health in men study.

Golledge J, Norman PE.

Hum Genet. 2008 Feb;123(1):35-40. Epub 2007 Nov 13.PMID: 17999084 [PubMed - indexed for MEDLINE]Related articles

Patterns of association between PPARgamma genetic variation and indices of adiposity and insulin action in African-Americans and whites: the CARDIA Study.

Wei Q, Jacobs DR Jr, Schreiner PJ, Siscovick DS, Steffes MW, Fornage M.

J Mol Med. 2006 Nov;84(11):955-65. Epub 2006 Sep 6.PMID: 16955276 [PubMed - indexed for MEDLINE]Related articles

Effect of pioglitazone on pancreatic beta-cell function and diabetes risk in Hispanic women with prior gestational diabetes.

Xiang AH, Peters RK, Kjos SL, Marroquin A, Goico J, Ochoa C, Kawakubo M, Buchanan TA.

Diabetes. 2006 Feb;55(2):517-22.PMID: 16443789 [PubMed - indexed for MEDLINE]Related articlesFree article

SNPs in PPARG associate with type 2 diabetes and interact with physical activity.

Kilpeläinen TO, Lakka TA, Laaksonen DE, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Lindi V, Tuomilehto J, Uusitupa M, Laakso M.

Med Sci Sports Exerc. 2008 Jan;40(1):25-33.PMID: 18091023 [PubMed - indexed for MEDLINE]Related articles