PubMed

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

Welsh N, Cnop M, Kharroubi I, Bugliani M, Lupi R, Marchetti P, Eizirik DL.

Diabetes. 2005 Nov;54(11):3238-44.PMID: 16249450 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY.

J Clin Invest. 2002 Sep;110(6):851-60.PMID: 12235117 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T, Dayer JM, Reinecke M, Halban PA, Donath MY.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8138-43. Epub 2004 May 12.PMID: 15141093 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, Pattou F, Halban PA, Weir GC, Donath MY.

J Clin Endocrinol Metab. 2008 Oct;93(10):4065-74. Epub 2008 Jul 29.PMID: 18664535 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.

Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL.

Diabetes. 2005 Dec;54 Suppl 2:S97-107. Review.PMID: 16306347 [PubMed - indexed for MEDLINE]Related articlesFree article

Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.

Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL.

Diabetologia. 2001 Mar;44(3):325-32.PMID: 11317664 [PubMed - indexed for MEDLINE]Related articles

A biphasic role of nuclear transcription factor (NF)-kappaB in the islet beta-cell apoptosis induced by interleukin (IL)-1beta.

Papaccio G, Graziano A, D'Aquino R, Valiante S, Naro F.

J Cell Physiol. 2005 Jul;204(1):124-30.PMID: 15622524 [PubMed - indexed for MEDLINE]Related articles

Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis.

Liu D, Darville M, Eizirik DL.

Endocrinology. 2001 Jun;142(6):2593-9.PMID: 11356709 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitory effects of epicatechin on interleukin-1beta-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation.

Kim MJ, Ryu GR, Kang JH, Sim SS, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Jeong IK, Hong KJ, Kim MS, Jo YH.

Biochem Pharmacol. 2004 Nov 1;68(9):1775-85.PMID: 15450943 [PubMed - indexed for MEDLINE]Related articles

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY.

Diabetes. 2004 Jul;53(7):1706-13.PMID: 15220194 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.

Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Théâtre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL.

Diabetologia. 2008 Jul;51(7):1213-25. Epub 2008 May 8.PMID: 18463842 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta.

Zeender E, Maedler K, Bosco D, Berney T, Donath MY, Halban PA.

J Clin Endocrinol Metab. 2004 Oct;89(10):5059-66.PMID: 15472206 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.

Giannoukakis N, Rudert WA, Ghivizzani SC, Gambotto A, Ricordi C, Trucco M, Robbins PD.

Diabetes. 1999 Sep;48(9):1730-6.PMID: 10480601 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenoviral overexpression of interleukin-1 receptor antagonist protein increases beta-cell replication in rat pancreatic islets.

Téllez N, Montolio M, Biarnés M, Castaño E, Soler J, Montanya E.

Gene Ther. 2005 Jan;12(2):120-8.PMID: 15578044 [PubMed - indexed for MEDLINE]Related articles

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets.

Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.

Diabetes. 2006 Oct;55(10):2713-22.PMID: 17003335 [PubMed - indexed for MEDLINE]Related articlesFree article

Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.

Liu D, Cardozo AK, Darville MI, Eizirik DL.

Endocrinology. 2002 Apr;143(4):1225-34.PMID: 11897677 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.PMID: 15297438 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice.

Cardozo AK, Proost P, Gysemans C, Chen MC, Mathieu C, Eizirik DL.

Diabetologia. 2003 Feb;46(2):255-66. Epub 2003 Feb 12.PMID: 12627325 [PubMed - indexed for MEDLINE]Related articles

Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro.

Sandler S, Bendtzen K, Eizirik DL, Welsh M.

Endocrinology. 1990 Feb;126(2):1288-94.PMID: 2404746 [PubMed - indexed for MEDLINE]Related articles