PubMed

Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes--androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens.

Schmidt M, Weidler C, Naumann H, Anders S, Schölmerich J, Straub RH.

Arthritis Res Ther. 2005;7(5):R938-48. Epub 2005 Jun 10.PMID: 16207335 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis.

Castagnetta LA, Carruba G, Granata OM, Stefano R, Miele M, Schmidt M, Cutolo M, Straub RH.

J Rheumatol. 2003 Dec;30(12):2597-605.PMID: 14719200 [PubMed - indexed for MEDLINE]Related articles

Estrone/17beta-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis.

Schmidt M, Hartung R, Capellino S, Cutolo M, Pfeifer-Leeg A, Straub RH.

Arthritis Rheum. 2009 Oct;60(10):2913-22.PMID: 19790073 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency.

Weidler C, Struharova S, Schmidt M, Ugele B, Schölmerich J, Straub RH.

Arthritis Rheum. 2005 Jun;52(6):1721-9.PMID: 15934093 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammation and sex hormone metabolism.

Schmidt M, Naumann H, Weidler C, Schellenberg M, Anders S, Straub RH.

Ann N Y Acad Sci. 2006 Jun;1069:236-46. Review.PMID: 16855150 [PubMed - indexed for MEDLINE]Related articles

Androgen formation and metabolism in the pulmonary epithelial cell line A549: expression of 17beta-hydroxysteroid dehydrogenase type 5 and 3alpha-hydroxysteroid dehydrogenase type 3.

Provost PR, Blomquist CH, Godin C, Huang XF, Flamand N, Luu-The V, Nadeau D, Tremblay Y.

Endocrinology. 2000 Aug;141(8):2786-94.PMID: 10919264 [PubMed - indexed for MEDLINE]Related articlesFree article

Synovial fluid estrogens in rheumatoid arthritis.

Cutolo M, Villaggio B, Seriolo B, Montagna P, Capellino S, Straub RH, Sulli A.

Autoimmun Rev. 2004 Mar;3(3):193-8. Review.PMID: 15110231 [PubMed - indexed for MEDLINE]Related articles

Anti-TNF and sex hormones.

Cutolo M, Sulli A, Capellino S, Villaggio B, Montagna P, Pizzorni C, Paolino S, Seriolo B, Felli L, Straub RH.

Ann N Y Acad Sci. 2006 Jun;1069:391-400.PMID: 16855166 [PubMed - indexed for MEDLINE]Related articles

Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study.

Straub RH, Härle P, Yamana S, Matsuda T, Takasugi K, Kishimoto T, Nishimoto N.

Arthritis Rheum. 2006 Jun;54(6):1778-85.PMID: 16729287 [PubMed - indexed for MEDLINE]Related articlesFree article

Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages.

Schmidt M, Kreutz M, Löffler G, Schölmerich J, Straub RH.

J Endocrinol. 2000 Feb;164(2):161-9.PMID: 10657851 [PubMed - indexed for MEDLINE]Related articlesFree article

Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response.

Furuzawa-Carballeda J, Macip-Rodríguez PM, Cabral AR.

Clin Exp Rheumatol. 2008 Jul-Aug;26(4):554-60.PMID: 18799084 [PubMed - indexed for MEDLINE]Related articles

5alpha-reductase isozymes and aromatase are differentially expressed and active in the androgen-independent human prostate cancer cell lines DU145 and PC3.

Negri-Cesi P, Colciago A, Poletti A, Motta M.

Prostate. 1999 Dec 1;41(4):224-32.PMID: 10544295 [PubMed - indexed for MEDLINE]Related articles

Steroid metabolism in the gonads of a patient with testicular feminization. II. Metabolism of c19- and c18-steroids in vitro.

Schindler AE.

Endokrinologie. 1976 Mar;67(1):14-9.PMID: 1244196 [PubMed - indexed for MEDLINE]Related articles

Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology.

Labrie F, Bélanger A, Cusan L, Candas B.

J Clin Endocrinol Metab. 1997 Aug;82(8):2403-9.PMID: 9253308 [PubMed - indexed for MEDLINE]Related articlesFree article

Hormone concentrations in synovial fluid of patients with rheumatoid arthritis.

Rovensky J, Kvetnansky R, Radikova Z, Imrich R, Greguska O, Vigas M, Macho L.

Clin Exp Rheumatol. 2005 May-Jun;23(3):292-6.PMID: 15971415 [PubMed - indexed for MEDLINE]Related articles

Differential expression and functional behaviour of the alpha v and beta 3 integrin subunits in cytokine stimulated fibroblast-like cells derived from synovial tissue of rheumatoid arthritis and osteoarthritis in vitro.

Rinaldi N, Weis D, Brado B, Schwarz-Eywill M, Lukoschek M, Pezzutto A, Keilholz U, Barth TF.

Ann Rheum Dis. 1997 Dec;56(12):729-36.PMID: 9496152 [PubMed - indexed for MEDLINE]Related articlesFree article

Competitive studies with dehydroepiandrosterone sulfate and 16 alpha-hydroxydehydroepiandrosterone sulfate in cultured human choriocarcinoma JEG-3 cells: effect on estrone, 17 beta-estradiol, and estriol secretion.

Zbella EA, Ilekis J, Scommegna A, Benveniste R.

J Clin Endocrinol Metab. 1986 Sep;63(3):751-7.PMID: 2942557 [PubMed - indexed for MEDLINE]Related articles

Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in humans.

Young J, Couzinet B, Nahoul K, Brailly S, Chanson P, Baulieu EE, Schaison G.

J Clin Endocrinol Metab. 1997 Aug;82(8):2578-85.PMID: 9253337 [PubMed - indexed for MEDLINE]Related articlesFree article

Preliminary observations on steroid metabolism in isolated epithelum of guinea pig seminal vesicle.

Steer RC, Veneziale CM.

Andrologia. 1977 Apr-Jun;9(2):141-54.PMID: 142430 [PubMed - indexed for MEDLINE]Related articles

Low density of CD1+ cells in the synovial tissue of patients with rheumatoid arthritis.

Weidler C, Kröll R, Miller LE, Schölmerich J, Grifka J, Straub RH.

Clin Exp Rheumatol. 2004 Jul-Aug;22(4):433-40.PMID: 15301240 [PubMed - indexed for MEDLINE]Related articles