PubMed

Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).

Krasowski MD, Yasuda K, Hagey LR, Schuetz EG.

Nucl Recept. 2005 Sep 30;3:2.PMID: 16197547 [PubMed]Related articlesFree article

Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.

Reschly EJ, Krasowski MD.

Curr Drug Metab. 2006 May;7(4):349-65. Review.PMID: 16724925 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional evolution of the vitamin D and pregnane X receptors.

Reschly EJ, Bainy AC, Mattos JJ, Hagey LR, Bahary N, Mada SR, Ou J, Venkataramanan R, Krasowski MD.

BMC Evol Biol. 2007 Nov 12;7:222.PMID: 17997857 [PubMed - indexed for MEDLINE]Related articlesFree article

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.

Moore LB, Maglich JM, McKee DD, Wisely B, Willson TM, Kliewer SA, Lambert MH, Moore JT.

Mol Endocrinol. 2002 May;16(5):977-86.PMID: 11981033 [PubMed - indexed for MEDLINE]Related articlesFree article

Evolution of pharmacologic specificity in the pregnane X receptor.

Ekins S, Reschly EJ, Hagey LR, Krasowski MD.

BMC Evol Biol. 2008 Apr 2;8:103.PMID: 18384689 [PubMed - indexed for MEDLINE]Related articlesFree article

Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts.

Krasowski MD, Yasuda K, Hagey LR, Schuetz EG.

Mol Endocrinol. 2005 Jul;19(7):1720-39. Epub 2005 Feb 17.PMID: 15718292 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional evolution of the pregnane X receptor.

Iyer M, Reschly EJ, Krasowski MD.

Expert Opin Drug Metab Toxicol. 2006 Jun;2(3):381-97. Review.PMID: 16863441 [PubMed - indexed for MEDLINE]Related articlesFree article

Evolution of a novel subfamily of nuclear receptors with members that each contain two DNA binding domains.

Wu W, Niles EG, Hirai H, LoVerde PT.

BMC Evol Biol. 2007 Feb 23;7:27.PMID: 17319953 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of Vitamin D receptor in the intestinal induction of human ABCB1.

Tachibana S, Yoshinari K, Chikada T, Toriyabe T, Nagata K, Yamazoe Y.

Drug Metab Dispos. 2009 Aug;37(8):1604-10. Epub 2009 May 21.PMID: 19460946 [PubMed - indexed for MEDLINE]Related articles

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects.

di Masi A, Marinis ED, Ascenzi P, Marino M.

Mol Aspects Med. 2009 Oct;30(5):297-343. Epub 2009 May 7. Review.PMID: 19427329 [PubMed - indexed for MEDLINE]Related articles

Genome inventory and analysis of nuclear hormone receptors in Tetraodon nigroviridis.

Metpally RP, Vigneshwar R, Sowdhamini R.

J Biosci. 2007 Jan;32(1):43-50. Erratum in: J Biosci. 2007 Jun;32(4):805. PMID: 17426379 [PubMed - indexed for MEDLINE]Related articlesFree article

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals.

Handschin C, Blättler S, Roth A, Looser R, Oscarson M, Kaufmann MR, Podvinec M, Gnerre C, Meyer UA.

Nucl Recept. 2004 Oct 12;2(1):7.PMID: 15479477 [PubMed - as supplied by publisher]Related articlesFree article

Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.

Roth A, Looser R, Kaufmann M, Blättler SM, Rencurel F, Huang W, Moore DD, Meyer UA.

Mol Pharmacol. 2008 Apr;73(4):1282-9. Epub 2008 Jan 10.PMID: 18187584 [PubMed - indexed for MEDLINE]Related articlesFree article

Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR.

Ueda A, Matsui K, Yamamoto Y, Pedersen LC, Sueyoshi T, Negishi M.

Biochem J. 2005 Jun 1;388(Pt 2):623-30.PMID: 15610065 [PubMed - indexed for MEDLINE]Related articlesFree article

Beyond the human genome: examples of nuclear receptor analysis in model organisms and potential for drug discovery.

Maglich JM, Sluder AE, Willson TM, Moore JT.

Am J Pharmacogenomics. 2003;3(5):345-53. Review.PMID: 14575522 [PubMed - indexed for MEDLINE]Related articles

The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.

Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B.

Mol Endocrinol. 2007 Sep;21(9):2099-111. Epub 2007 Jun 26.PMID: 17595319 [PubMed - indexed for MEDLINE]Related articlesFree article

Insights from a three-dimensional model into ligand binding to constitutive active receptor.

Xiao L, Cui X, Madison V, White RE, Cheng KC.

Drug Metab Dispos. 2002 Sep;30(9):951-6.PMID: 12167558 [PubMed - indexed for MEDLINE]Related articlesFree article

The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor.

Liu MJ, Takahashi Y, Wada T, He J, Gao J, Tian Y, Li S, Xie W.

Mol Pharmacol. 2009 Sep;76(3):604-11. Epub 2009 Jun 19.PMID: 19542321 [PubMed - indexed for MEDLINE]Related articles

DNA binding and transactivation properties of the Schistosoma mansoni constitutive androstane receptor homologue.

Hu R, Niles EG, LoVerde PT.

Mol Biochem Parasitol. 2006 Dec;150(2):174-85. Epub 2006 Aug 22.PMID: 16962182 [PubMed - indexed for MEDLINE]Related articles

Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity.

Windshügel B, Jyrkkärinne J, Poso A, Honkakoski P, Sippl W.

J Mol Model. 2005 Feb;11(1):69-79. Epub 2004 Dec 23.PMID: 15616833 [PubMed - indexed for MEDLINE]Related articles