PubMed

Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.

Lankas GR, Leiting B, Roy RS, Eiermann GJ, Beconi MG, Biftu T, Chan CC, Edmondson S, Feeney WP, He H, Ippolito DE, Kim D, Lyons KA, Ok HO, Patel RA, Petrov AN, Pryor KA, Qian X, Reigle L, Woods A, Wu JK, Zaller D, Zhang X, Zhu L, Weber AE, Thornberry NA.

Diabetes. 2005 Oct;54(10):2988-94.PMID: 16186403 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological profile of ASP8497, a novel, selective, and competitive dipeptidyl peptidase-IV inhibitor, in vitro and in vivo.

Someya Y, Tahara A, Nakano R, Matsuyama-Yokono A, Nagase I, Fukunaga Y, Takasu T, Hayakawa M, Shibasaki M.

Naunyn Schmiedebergs Arch Pharmacol. 2008 May;377(3):209-17. Epub 2008 Apr 9.PMID: 18398600 [PubMed - indexed for MEDLINE]Related articles

7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one is a novel competitive and selective inhibitor of dipeptidyl peptidase IV with an antihyperglycemic activity.

Yamazaki K, Yasuda N, Inoue T, Nagakura T, Kira K, Shinoda M, Saeki T, Tanaka I.

J Pharmacol Exp Ther. 2006 Dec;319(3):1253-7. Epub 2006 Sep 15.PMID: 16980568 [PubMed - indexed for MEDLINE]Related articlesFree article

Adverse effects of dipeptidyl peptidases 8 and 9 inhibition in rodents revisited.

Burkey BF, Hoffmann PK, Hassiepen U, Trappe J, Juedes M, Foley JE.

Diabetes Obes Metab. 2008 Nov;10(11):1057-61. Epub 2008 Apr 17.PMID: 18422675 [PubMed - indexed for MEDLINE]Related articles

2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

Tsu H, Chen X, Chen CT, Lee SJ, Chang CN, Kao KH, Coumar MS, Yeh YT, Chien CH, Wang HS, Lin KT, Chang YY, Wu SH, Chen YS, Lu IL, Wu SY, Tsai TY, Chen WC, Hsieh HP, Chao YS, Jiaang WT.

J Med Chem. 2006 Jan 12;49(1):373-80.PMID: 16392822 [PubMed - indexed for MEDLINE]Related articles

Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Thornberry NA, Weber AE.

Curr Top Med Chem. 2007;7(6):557-68. Review.PMID: 17352677 [PubMed - indexed for MEDLINE]Related articles

Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors.

Lu IL, Lee SJ, Tsu H, Wu SY, Kao KH, Chien CH, Chang YY, Chen YS, Cheng JH, Chang CN, Chen TW, Chang SP, Chen X, Jiaang WT.

Bioorg Med Chem Lett. 2005 Jul 1;15(13):3271-5.PMID: 15927466 [PubMed - indexed for MEDLINE]Related articles

Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor.

Wu JJ, Tang HK, Yeh TK, Chen CM, Shy HS, Chu YR, Chien CH, Tsai TY, Huang YC, Huang YL, Huang CH, Tseng HY, Jiaang WT, Chao YS, Chen X.

Biochem Pharmacol. 2009 Jul 15;78(2):203-10. Epub 2009 Apr 11.PMID: 19439267 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase 8/9-like activity in human leukocytes.

Maes MB, Dubois V, Brandt I, Lambeir AM, Van der Veken P, Augustyns K, Cheng JD, Chen X, Scharpé S, De Meester I.

J Leukoc Biol. 2007 May;81(5):1252-7. Epub 2007 Feb 7.PMID: 17287297 [PubMed - indexed for MEDLINE]Related articlesFree article

E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor.

Yasuda N, Nagakura T, Inoue T, Yamazaki K, Katsutani N, Takenaka O, Clark R, Matsuura F, Emori E, Yoshikawa S, Kira K, Ikuta H, Okada T, Saeki T, Asano O, Tanaka I.

Eur J Pharmacol. 2006 Oct 24;548(1-3):181-7. Epub 2006 Aug 16.PMID: 16973152 [PubMed - indexed for MEDLINE]Related articles

Prolyl peptidases related to dipeptidyl peptidase IV: potential of specific inhibitors in drug discovery.

Van der Veken P, Haemers A, Augustyns K.

Curr Top Med Chem. 2007;7(6):621-35. Review.PMID: 17352682 [PubMed - indexed for MEDLINE]Related articles

Type 2 diabetes--therapy with dipeptidyl peptidase IV inhibitors.

Demuth HU, McIntosh CH, Pederson RA.

Biochim Biophys Acta. 2005 Aug 1;1751(1):33-44. Review.PMID: 15978877 [PubMed - indexed for MEDLINE]Related articles

Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety.

Connolly BA, Sanford DG, Chiluwal AK, Healey SE, Peters DE, Dimare MT, Wu W, Liu Y, Maw H, Zhou Y, Li Y, Jin Z, Sudmeier JL, Lai JH, Bachovchin WW.

J Med Chem. 2008 Oct 9;51(19):6005-13. Epub 2008 Sep 11.PMID: 18783201 [PubMed - indexed for MEDLINE]Related articles

(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors.

Thomas L, Eckhardt M, Langkopf E, Tadayyon M, Himmelsbach F, Mark M.

J Pharmacol Exp Ther. 2008 Apr;325(1):175-82. Epub 2008 Jan 25.PMID: 18223196 [PubMed - indexed for MEDLINE]Related articlesFree article

Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.

Longenecker KL, Stewart KD, Madar DJ, Jakob CG, Fry EH, Wilk S, Lin CW, Ballaron SJ, Stashko MA, Lubben TH, Yong H, Pireh D, Pei Z, Basha F, Wiedeman PE, von Geldern TW, Trevillyan JM, Stoll VS.

Biochemistry. 2006 Jun 20;45(24):7474-82.PMID: 16768443 [PubMed - indexed for MEDLINE]Related articles

Inhibition of dipeptidylpeptidase IV activity as a therapy of type 2 diabetes.

Green BD, Flatt PR, Bailey CJ.

Expert Opin Emerg Drugs. 2006 Sep;11(3):525-39. Review.PMID: 16939389 [PubMed - indexed for MEDLINE]Related articles

The therapeutic potential of inhibitors of dipeptidyl peptidase IV (DPP IV) and related proline-specific dipeptidyl aminopeptidases.

Augustyns K, Van der Veken P, Senten K, Haemers A.

Curr Med Chem. 2005;12(8):971-98. Review.PMID: 15853709 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase-IV inhibitors: a major new class of oral antidiabetic drug.

Idris I, Donnelly R.

Diabetes Obes Metab. 2007 Mar;9(2):153-65. Review.PMID: 17300591 [PubMed - indexed for MEDLINE]Related articles

ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity.

Matsuyama-Yokono A, Tahara A, Nakano R, Someya Y, Nagase I, Hayakawa M, Shibasaki M.

Biochem Pharmacol. 2008 Jul 1;76(1):98-107. Epub 2008 Apr 6.PMID: 18468582 [PubMed - indexed for MEDLINE]Related articles

Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.

Reinhold D, Goihl A, Wrenger S, Reinhold A, Kühlmann UC, Faust J, Neubert K, Thielitz A, Brocke S, Täger M, Ansorge S, Bank U.

Clin Chem Lab Med. 2009;47(3):268-74.PMID: 19676138 [PubMed - indexed for MEDLINE]Related articles