PubMed

Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

Busch AK, Gurisik E, Cordery DV, Sudlow M, Denyer GS, Laybutt DR, Hughes WE, Biden TJ.

Diabetes. 2005 Oct;54(10):2917-24.PMID: 16186393 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.

Lai E, Bikopoulos G, Wheeler MB, Rozakis-Adcock M, Volchuk A.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E540-50. Epub 2008 Jan 15.PMID: 18198352 [PubMed - indexed for MEDLINE]Related articlesFree article

Triglyceride accumulation protects against fatty acid-induced lipotoxicity.

Listenberger LL, Han X, Lewis SE, Cases S, Farese RV Jr, Ory DS, Schaffer JE.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3077-82. Epub 2003 Mar 10.PMID: 12629214 [PubMed - indexed for MEDLINE]Related articlesFree article

Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells.

Yee JK, Mao CS, Hummel HS, Lim S, Sugano S, Rehan VK, Xiao G, Lee WN.

J Lipid Res. 2008 Oct;49(10):2124-34. Epub 2008 Jul 3.PMID: 18599738 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: implications for a role of stearoyl-CoA desaturase 1 in insulin resistance.

Voss MD, Beha A, Tennagels N, Tschank G, Herling AW, Quint M, Gerl M, Metz-Weidmann C, Haun G, Korn M.

Diabetologia. 2005 Dec;48(12):2622-30. Epub 2005 Nov 12.PMID: 16284748 [PubMed - indexed for MEDLINE]Related articles

Lack of stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA Delta6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial glands of the mouse.

Miyazaki M, Gomez FE, Ntambi JM.

J Lipid Res. 2002 Dec;43(12):2146-54.PMID: 12454277 [PubMed - indexed for MEDLINE]Related articlesFree article

The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatoma 7288C.

Zoeller RA, Wood R.

Biochim Biophys Acta. 1985 Jun 30;845(3):380-8.PMID: 2860925 [PubMed - indexed for MEDLINE]Related articles

Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells.

Scaglia N, Igal RA.

J Biol Chem. 2005 Jul 8;280(27):25339-49. Epub 2005 Apr 25.PMID: 15851470 [PubMed - indexed for MEDLINE]Related articlesFree article

Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations.

Ramanadham S, Zhang S, Ma Z, Wohltmann M, Bohrer A, Hsu FF, Turk J.

Biochim Biophys Acta. 2002 Jan 30;1580(1):40-56.PMID: 11923099 [PubMed - indexed for MEDLINE]Related articles

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo.

Peter A, Weigert C, Staiger H, Machicao F, Schick F, Machann J, Stefan N, Thamer C, Häring HU, Schleicher E.

Diabetes. 2009 Aug;58(8):1757-65. Epub 2009 May 28.PMID: 19478146 [PubMed - indexed for MEDLINE]Related articlesFree article

Recent insights into stearoyl-CoA desaturase-1.

Ntambi JM, Miyazaki M.

Curr Opin Lipidol. 2003 Jun;14(3):255-61. Review.PMID: 12840656 [PubMed - indexed for MEDLINE]Related articles

Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism.

Flowers MT, Ntambi JM.

Curr Opin Lipidol. 2008 Jun;19(3):248-56. Review.PMID: 18460915 [PubMed - indexed for MEDLINE]Related articles

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids.

Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V.

Diabetes. 2001 Feb;50(2):315-21.PMID: 11272142 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function.

Busch AK, Cordery D, Denyer GS, Biden TJ.

Diabetes. 2002 Apr;51(4):977-87.PMID: 11916915 [PubMed - indexed for MEDLINE]Related articlesFree article

Stearoyl-CoA desaturase--a new player in skeletal muscle metabolism regulation.

Dobrzyń A, Dobrzyń P.

J Physiol Pharmacol. 2006 Nov;57 Suppl 10:31-42. Review.PMID: 17242489 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity.

Peter A, Weigert C, Staiger H, Rittig K, Cegan A, Lutz P, Machicao F, Häring HU, Schleicher E.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E339-49. Epub 2008 Jun 3.PMID: 18523127 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice.

Flowers JB, Rabaglia ME, Schueler KL, Flowers MT, Lan H, Keller MP, Ntambi JM, Attie AD.

Diabetes. 2007 May;56(5):1228-39. Epub 2007 Mar 16.PMID: 17369521 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequential ordered fatty acid alpha oxidation and Delta9 desaturation are major determinants of lipid storage and utilization in differentiating adipocytes.

Su X, Han X, Yang J, Mancuso DJ, Chen J, Bickel PE, Gross RW.

Biochemistry. 2004 May 4;43(17):5033-44.PMID: 15109262 [PubMed - indexed for MEDLINE]Related articles

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG.

Diabetes. 2001 Aug;50(8):1771-7.PMID: 11473037 [PubMed - indexed for MEDLINE]Related articlesFree article