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Results: 1 to 20 of 171

1.

Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours.

Kucab JE, Lee C, Chen CS, Zhu J, Gilks CB, Cheang M, Huntsman D, Yorida E, Emerman J, Pollak M, Dunn SE.

Breast Cancer Res. 2005;7(5):R796-807. Epub 2005 Aug 1.PMID: 16168126 [PubMed - indexed for MEDLINE]Related articlesFree article

2.

Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.

Kim N, Kim CH, Ahn DW, Lee KS, Cho SJ, Park JH, Lee MK, Kim JS, Jung HC, Song IS.

J Gastroenterol Hepatol. 2009 Mar;24(3):480-7. Epub 2008 Sep 24.PMID: 18823436 [PubMed - indexed for MEDLINE]Related articles

3.

The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells.

Wu T, Leng J, Han C, Demetris AJ.

Mol Cancer Ther. 2004 Mar;3(3):299-307.PMID: 15026550 [PubMed - indexed for MEDLINE]Related articlesFree article

4.

Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells.

Basu GD, Pathangey LB, Tinder TL, Gendler SJ, Mukherjee P.

Breast Cancer Res. 2005;7(4):R422-35. Epub 2005 Apr 4.PMID: 15987447 [PubMed - indexed for MEDLINE]Related articlesFree article

5.

From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors.

Zhu J, Huang JW, Tseng PH, Yang YT, Fowble J, Shiau CW, Shaw YJ, Kulp SK, Chen CS.

Cancer Res. 2004 Jun 15;64(12):4309-18.PMID: 15205346 [PubMed - indexed for MEDLINE]Related articlesFree article

6.

The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2.

Hsu AL, Ching TT, Wang DS, Song X, Rangnekar VM, Chen CS.

J Biol Chem. 2000 Apr 14;275(15):11397-403.PMID: 10753955 [PubMed - indexed for MEDLINE]Related articlesFree article

7.

Involvement of mitochondrial and Akt signaling pathways in augmented apoptosis induced by a combination of low doses of celecoxib and N-(4-hydroxyphenyl) retinamide in premalignant human bronchial epithelial cells.

Schroeder CP, Kadara H, Lotan D, Woo JK, Lee HY, Hong WK, Lotan R.

Cancer Res. 2006 Oct 1;66(19):9762-70.PMID: 17018636 [PubMed - indexed for MEDLINE]Related articlesFree article

8.

Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor.

Weng SC, Kashida Y, Kulp SK, Wang D, Brueggemeier RW, Shapiro CL, Chen CS.

Mol Cancer Ther. 2008 Apr;7(4):800-8.PMID: 18413793 [PubMed - indexed for MEDLINE]Related articlesFree article

9.

Inhibition of either phosphatidylinositol 3-kinase/Akt or the mitogen/extracellular-regulated kinase, MEK/ERK, signaling pathways suppress growth of breast cancer cell lines, but MEK/ERK signaling is critical for cell survival.

Ripple MO, Kalmadi S, Eastman A.

Breast Cancer Res Treat. 2005 Sep;93(2):177-88.PMID: 16187238 [PubMed - indexed for MEDLINE]Related articles

10.

Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor.

Tseng PH, Wang YC, Weng SC, Weng JR, Chen CS, Brueggemeier RW, Shapiro CL, Chen CY, Dunn SE, Pollak M, Chen CS.

Mol Pharmacol. 2006 Nov;70(5):1534-41. Epub 2006 Aug 3.PMID: 16887935 [PubMed - indexed for MEDLINE]Related articlesFree article

11.

Synergistic tumoricidal effect between celecoxib and adenoviral-mediated delivery of mda-7 in human breast cancer cells.

Suh YJ, Chada S, McKenzie T, Liu Y, Swisher SG, Lucci A, Hunt KK.

Surgery. 2005 Sep;138(3):422-30.PMID: 16213894 [PubMed - indexed for MEDLINE]Related articles

12.

Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents.

Zhu J, Song X, Lin HP, Young DC, Yan S, Marquez VE, Chen CS.

J Natl Cancer Inst. 2002 Dec 4;94(23):1745-57.PMID: 12464646 [PubMed - indexed for MEDLINE]Related articlesFree article

13.

Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction.

Jacobshagen C, Grüber M, Teucher N, Schmidt AG, Unsöld BW, Toischer K, Nguyen VP, Maier LS, Kögler H, Hasenfuss G.

Eur J Heart Fail. 2008 Apr;10(4):334-42. Epub 2008 Mar 17.PMID: 18343721 [PubMed - indexed for MEDLINE]Related articles

14.

OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms.

Zhang S, Suvannasankha A, Crean CD, White VL, Johnson A, Chen CS, Farag SS.

Clin Cancer Res. 2007 Aug 15;13(16):4750-8.PMID: 17699852 [PubMed - indexed for MEDLINE]Related articlesFree article

15.

3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells.

Kulp SK, Yang YT, Hung CC, Chen KF, Lai JP, Tseng PH, Fowble JW, Ward PJ, Chen CS.

Cancer Res. 2004 Feb 15;64(4):1444-51.PMID: 14973075 [PubMed - indexed for MEDLINE]Related articlesFree article

16.

Keratinocyte growth factor (KGF) regulates estrogen receptor-alpha (ER-alpha) expression and cell apoptosis via phosphatidylinositol 3-kinase (PI3K)/Akt pathway in human breast cancer cells.

Chang HL, Sugimoto Y, Liu S, Wang LS, Huang YW, Ye W, Lin YC.

Anticancer Res. 2009 Aug;29(8):3195-205.PMID: 19661335 [PubMed - indexed for MEDLINE]Related articles

17.

Celecoxib, a cyclooxygenase-2 inhibitor, reduces neointimal hyperplasia through inhibition of Akt signaling.

Yang HM, Kim HS, Park KW, You HJ, Jeon SI, Youn SW, Kim SH, Oh BH, Lee MM, Park YB, Walsh K.

Circulation. 2004 Jul 20;110(3):301-8. Epub 2004 Jul 6.PMID: 15238462 [PubMed - indexed for MEDLINE]Related articlesFree article

18.

Effect of simultaneous inhibition of epidermal growth factor receptor and cyclooxygenase-2 in HER-2/neu-positive breast cancer.

Lanza-Jacoby S, Burd R, Rosato FE Jr, McGuire K, Little J, Nougbilly N, Miller S.

Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6161-9.PMID: 17062693 [PubMed - indexed for MEDLINE]Related articlesFree article

19.

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.

Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.PMID: 16854453 [PubMed - indexed for MEDLINE]Related articles

20.

Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer.

Basu GD, Pathangey LB, Tinder TL, Lagioia M, Gendler SJ, Mukherjee P.

Mol Cancer Res. 2004 Nov;2(11):632-42.PMID: 15561779 [PubMed - indexed for MEDLINE]Related articlesFree article

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