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New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated).

Macias WL, Yan SB, Williams MD, Um SL, Sandusky GE, Ballard DW, Planquois JM.

Crit Care. 2005;9 Suppl 4:S38-45. Epub 2005 Aug 25. Review.PMID: 16168074 [PubMed - indexed for MEDLINE]Related articles

Endogenous protein C activation in patients with severe sepsis.

Liaw PC.

Crit Care Med. 2004 May;32(5 Suppl):S214-8. Review.PMID: 15118520 [PubMed - indexed for MEDLINE]Related articles

Benefit-risk assessment of drotrecogin alfa (activated) in the treatment of sepsis.

De Backer D.

Drug Saf. 2007;30(11):995-1010. Review.PMID: 17973539 [PubMed - indexed for MEDLINE]Related articles

Activated protein C versus protein C in severe sepsis.

Yan SB, Dhainaut JF.

Crit Care Med. 2001 Jul;29(7 Suppl):S69-74. Review.PMID: 11445737 [PubMed - indexed for MEDLINE]Related articles

Inflammation, sepsis, and coagulation.

Esmon CT, Fukudome K, Mather T, Bode W, Regan LM, Stearns-Kurosawa DJ, Kurosawa S.

Haematologica. 1999 Mar;84(3):254-9. Review.PMID: 10189392 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated protein C and sepsis.

O'Brien LA, Gupta A, Grinnell BW.

Front Biosci. 2006 Jan 1;11:676-98. Review.PMID: 16146761 [PubMed - indexed for MEDLINE]Related articles

Soluble thrombomodulin, plasma-derived unactivated protein C, and recombinant human activated protein C in sepsis.

Dhainaut JF, Yan SB, Cariou A, Mira JP.

Crit Care Med. 2002 May;30(5 Suppl):S318-24. Review.PMID: 12004254 [PubMed - indexed for MEDLINE]Related articles

Leukocyte and endothelial cell interactions in sepsis: relevance of the protein C pathway.

Joyce DE, Nelson DR, Grinnell BW.

Crit Care Med. 2004 May;32(5 Suppl):S280-6. Review.PMID: 15118531 [PubMed - indexed for MEDLINE]Related articles

Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation.

Finigan JH, Dudek SM, Singleton PA, Chiang ET, Jacobson JR, Camp SM, Ye SQ, Garcia JG.

J Biol Chem. 2005 Apr 29;280(17):17286-93. Epub 2005 Feb 14.PMID: 15710622 [PubMed - indexed for MEDLINE]Related articlesFree article

The protein C pathway.

Esmon CT.

Chest. 2003 Sep;124(3 Suppl):26S-32S. Review.PMID: 12970121 [PubMed - indexed for MEDLINE]Related articlesFree article

The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells.

Bae JS, Yang L, Manithody C, Rezaie AR.

Blood. 2007 Dec 1;110(12):3909-16. Epub 2007 Sep 6.PMID: 17823308 [PubMed - indexed for MEDLINE]Related articlesFree article

Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis.

Dhainaut JF, Yan SB, Margolis BD, Lorente JA, Russell JA, Freebairn RC, Spapen HD, Riess H, Basson B, Johnson G 3rd, Kinasewitz GT; PROWESS Sepsis Study Group.

Thromb Haemost. 2003 Oct;90(4):642-53.PMID: 14515185 [PubMed - indexed for MEDLINE]Related articles

[The numerous properties of the anticoagulant protein C]

Cerchiara E, Tirindelli MC, Giannetti B, Dicuonzo G, Avvisati G.

Clin Ter. 2007 Mar-Apr;158(2):181-7. Review. Italian. PMID: 17566522 [PubMed - indexed for MEDLINE]Related articles

Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation.

Van de Wouwer M, Collen D, Conway EM.

Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1374-83. Epub 2004 Jun 3. Review.PMID: 15178554 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.

Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV.

Blood. 2003 Jun 15;101(12):4797-801. Epub 2003 Feb 13.PMID: 12586611 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-inflammatory effect of activated protein C in gastric epithelial cells.

Nakamura M, Gabazza EC, Imoto I, Yano Y, Taguchi O, Horiki N, Fukudome K, Suzuki K, Adachi Y.

J Thromb Haemost. 2005 Dec;3(12):2721-9. Epub 2005 Oct 25.PMID: 16246255 [PubMed - indexed for MEDLINE]Related articles

Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells.

Bae JS, Yang L, Rezaie AR.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2867-72. Epub 2007 Feb 13.PMID: 17299037 [PubMed - indexed for MEDLINE]Related articlesFree article

Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis.

Barton P, Kalil AC, Nadel S, Goldstein B, Okhuysen-Cawley R, Brilli RJ, Takano JS, Martin LD, Quint P, Yeh TS, Dalton HJ, Gessouron MR, Brown KE, Betts H, Levin M, Macias WL, Small DS, Wyss VL, Bates BM, Utterback BG, Giroir BP.

Pediatrics. 2004 Jan;113(1 Pt 1):7-17.PMID: 14702440 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of endothelial cell injury by activated protein C: the molecular mechanism(s) and therapeutic implications.

Okajima K.

Curr Vasc Pharmacol. 2004 Apr;2(2):125-33. Review.PMID: 15320513 [PubMed - indexed for MEDLINE]Related articles

The cytoprotective protein C pathway.

Mosnier LO, Zlokovic BV, Griffin JH.

Blood. 2007 Apr 15;109(8):3161-72. Epub 2006 Nov 16. Review.PMID: 17110453 [PubMed - indexed for MEDLINE]Related articlesFree article